Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells

Marcuzzo, Stefania; Kapetis, Dimos; Mantegazza, Renato; Baggi, Fulvio; Bonanno, Silvia; Barzago, Claudia; Cavalcante, Paola; Rosbo, Nicole Kerlero de; Bernasconi, Pia

doi:10.1016/j.expneurol.2013.12.007

Cited by 33 publications

(40 citation statements)

References 53 publications

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“…Interestingly, in mice Pten is repressed by Hes1 as part of the Notch signaling pathway ( Wong et al, 2012 ). Together with Hes1 (and other genes like Socs1 or Stat3 ), Pten comprisses a functional network that plays an important role in the control of the fate of ependymal stem progenitor cells of the spinal cord in response to motoneuron degeneration ( Marcuzzo et al, 2014 ). Hes1, Notch1, Akt1, and Pten are functionally related ( Palomero et al, 2008 ).…”

Section: Resultsmentioning

confidence: 99%

Globularity and language-readiness: generating new predictions by expanding the set of genes of interest

Boeckx

Benítez‐Burraco

2014

Front. Psychol.

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This study builds on the hypothesis put forth in Boeckx and Benítez-Burraco (2014), according to which the developmental changes expressed at the levels of brain morphology and neural connectivity that resulted in a more globular braincase in our species were crucial to understand the origins of our language-ready brain. Specifically, this paper explores the links between two well-known ‘language-related’ genes like FOXP2 and ROBO1 implicated in vocal learning and the initial set of genes of interest put forth in Boeckx and Benítez-Burraco (2014), with RUNX2 as focal point. Relying on the existing literature, we uncover potential molecular links that could be of interest to future experimental inquiries into the biological foundations of language and the testing of our initial hypothesis. Our discussion could also be relevant for clinical linguistics and for the interpretation of results from paleogenomics.

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Section: Resultsmentioning

confidence: 99%

Globularity and language-readiness: generating new predictions by expanding the set of genes of interest

Boeckx

Benítez‐Burraco

2014

Front. Psychol.

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“…Elevated miR-124 levels are thought to have a calming effect on microglia, as miR-124 is expressed by stressed neurons associated with neurodegeneration (Ponomarev et al, 2011). In addition, the elevated levels seem to be negatively correlated with the STAT3 transcription factor, a key factor for neural differentiation and cell survival (Marcuzzo et al, 2014). In a study of neural stem cells from ALS transgenic mice, Zhou et al (2018) showed that miR-124 was downregulated in the brainstem and spinal cord, and that miR-124 may participate in astrocyte differentiation of ALS transgenic mice by targeting Sox2 and Sox9.…”

Section: Mir-124 In Neurodegenerative Disordersmentioning

confidence: 99%

MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders

et al. 2020

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Neurodegenerative disorders (NDDs) are a group of chronic progressive neurological diseases based on primary neurodegeneration. The common pathological characteristics of various NDDs are neuronal degeneration, deletion, glial cell proliferation, and hypertrophy at specific locations in the nervous system. Proliferation and hypertrophy of microglia are manifestations of inflammation. MicroRNAs (miRNAs) have emerged as pivotal regulators of glial cells. MiRNAs are small non-coding molecules that regulate gene expression. Altered expression of miRNAs has been associated with several NDD pathological processes, among which regulation of the inflammatory response is key and a research hotspot at present. At the same time, miRNAs are also biological markers for diagnosis and potential targets for treating NDDs. MiR-124 is highly conserved and enriched in the mammalian brain. Emerging studies have suggested that miR-124 is closely related to the pathogenesis of NDDs and may be an effective treatment strategy to reduce inflammation associated with NDDs. In this review, we describe a summary of general miRNA biology, implications in pathophysiology, the potential roles of miR-124 associated with inflammation, and the use of miRNA as a future biomarker and an application for NDD therapy.

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“…Numerous studies in ALS models, including those harboring mutations in copper/zinc superoxide dismutase (mtSOD1), and patient samples have demonstrated a disruption of miRNA expression in ALS (Williams et al, 2009; Butovsky et al, 2012; Koval et al, 2013; Parisi et al, 2013; Zhou et al, 2013; Marcuzzo et al, 2014; Toivonen et al, 2014; Dobrowolny et al, 2015). The most consistent observation from the mtSOD1 mice is the upregulation of miR-9 and miR-206 (Williams et al, 2009; Zhou et al, 2013; Toivonen et al, 2014; Dobrowolny et al, 2015).…”

Section: Mirnas In Motor Neuron Diseases: Dysregulation Diagnosis Anmentioning

confidence: 99%

MotomiRs: miRNAs in Motor Neuron Function and Disease

Hawley

Campos-Melo

Droppelmann

et al. 2017

Front. Mol. Neurosci.

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MiRNAs are key regulators of the mammalian transcriptome that have been increasingly linked to degenerative diseases of the motor neurons. Although many of the miRNAs currently incriminated as participants in the pathogenesis of these diseases are also important to the normal development and function of motor neurons, at present there is no knowledge of the complete miRNA profile of motor neurons. In this review, we examine the current understanding with respect to miRNAs that are specifically required for motor neuron development, function and viability, and provide evidence that these should be considered as a functional network of miRNAs which we have collectively termed MotomiRs. We will also summarize those MotomiRs currently known to be associated with both amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), and discuss their potential use as biomarkers.

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Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells

Cited by 33 publications

References 53 publications

Globularity and language-readiness: generating new predictions by expanding the set of genes of interest

Globularity and language-readiness: generating new predictions by expanding the set of genes of interest

MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders

MotomiRs: miRNAs in Motor Neuron Function and Disease

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