Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period

Zhang, Luping; Huang, Jinwen; Zhang, Zhengxiang; Cao, Zhijian

doi:10.3389/fneur.2021.656349

“…The occipital cortex was the hub for visual perception and processing, and the temporo-occipital cortex also had complex functional connections including multisensory integration responsible for visual, auditory, and tactile information [39,40]. The indicator of occipital activity and neural synchronous were lower in migraine patients, and were generally thought to be associated with visual aura [41,42]. We also observed functional changes in the occipital cortex in young women with migraine without aura.…”

Section: Characteristics Of Changes Of Brain Spontaneous Activity And...mentioning

confidence: 57%

Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study

Yang,

Wei,

Zhang

et al. 2024

BMC Complement Med Ther

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Objective To investigate the changes in amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) values before and after acupuncture in young women with non-menstrual migraine without aura (MWoA) through rest blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI). Methods Patients with non-menstrual MWoA (Group 1, n = 50) and healthy controls (Group 2, n = 50) were recruited. fMRI was performed in Group 1 at 2 time points: before acupuncture (time point 1, TP1); and after the end of all acupuncture sessions (time point 2, TP2), and performed in Group 2 as a one-time scan. Patients in Group 1 were assessed with the Migraine Disability Assessment Questionnaire (MIDAS) and the Short-Form McGill Pain Questionnaire (SF-MPQ) at TP1 and TP2 after fMRI was performed. The ALFF and DC values were compared within Group 1 at two time points and between Group 1 and Group2. The correlation between ALFF and DC values with the statistical differences and the clinical scales scores were analyzed. Results Brain activities increased in the left fusiform gyrus and right angular gyrus, left middle occipital gyrus, and bilateral prefrontal cortex and decreased in left inferior parietal lobule in Group 1, which had different ALFF values compared with Group 2 at TP1. The bilateral fusiform gyrus, bilateral inferior temporal gyrus and right middle temporal gyrus increased and right angular gyrus, right superior marginal gyrus, right inferior parietal lobule, right middle occipital gyrus, right superior frontal gyrus, right middle frontal gyrus, right anterior central gyrus, and right supplementary motor area decreased in activity in Group 1 had different DC values compared with Group 2 at TP1. ALFF and DC values of right inferior temporal gyrus, right fusiform gyrus and right middle temporal gyrus were decreased in Group1 at TP1 compared with TP2. ALFF values in the left middle occipital area were positively correlated with the pain degree at TP1 in Group1 (correlation coefficient r, r = 0.827, r = 0.343; P < 0.01, P = 0.015). The DC values of the right inferior temporal area were positively correlated with the pain degree at TP1 in Group 1 (r = 0.371; P = 0.008). Conclusion Spontaneous brain activity and network changes in young women with non-menstrual MwoA were altered by acupuncture. The right temporal area may be an important target for acupuncture modulated brain function in young women with non-menstrual MwoA.

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“…The occipital cortex was the hub for visual perception and processing, and the temporo-occipital cortex also had complex functional connections including multisensory integration responsible for visual, auditory, and tactile information [23,24]. The indicator of occipital activity and neural synchronous were lower in migraine patients, and were generally thought to be associated with visual aura [25,26]. We also observed functional changes in the occipital cortex in young women with migraine without aura.…”

Section: Discussionmentioning

confidence: 69%

Modulation of temporal and occipital cortex by acupuncture in non- menstrual MWoA patients: A Rest Bold fMRI study

Yang

¹

,

Wei

²

,

Zhang

³

et al. 2023

Preprint

0

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Objective To investigate the changes in amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) values before and after acupuncture in young women with non-menstrual migraine without aura (MWoA) through rest blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI). Methods Patients with non-menstrual MWoA (Group 1, n = 50) and healthy controls (Group 2, n = 50) were recruited. fMRI was performed in Group 1 at 2 time points: before acupuncture (time point 1, TP1); and after the end of all acupuncture sessions (time point 2, TP2), and performed in Group 2 as a one-time scan. Patients in Group 1 were assessed with the Migraine Disability Assessment Questionnaire (MIDAS) and the Short-Form McGill Pain Questionnaire (SF-MPQ) at TP1 and TP2 after fMRI was performed. The ALFF and DC values were compared within Group 1 at two time points and between Group 1 and Group2. The correlation between ALFF and DC values with the statistical differences and the clinical scales scores were analyzed. Results Brain activities increased in the left fusiform gyrus and right angular gyrus, left middle occipital gyrus, and bilateral prefrontal cortex and decreased in left inferior parietal lobule in Group 1, which had different ALFF values compared with Group 2 at TP1. The bilateral fusiform gyrus, bilateral inferior temporal gyrus and right middle temporal gyrus increased and right angular gyrus, right superior marginal gyrus, right inferior parietal lobule, right middle occipital gyrus, right superior frontal gyrus, right middle frontal gyrus, right anterior central gyrus, and right supplementary motor area decreased in activity in Group 1 had different DC values compared with Group 2 at TP1. ALFF and DC values of right inferior temporal gyrus, right fusiform gyrus and right middle temporal gyrus were decreased in Group1 at TP1 compared with TP2. ALFF values in the left middle occipital area were positively correlated with the pain degree at TP1 in Group1 (correlation coefficient r, r = 0.827, r = 0.343; P < 0.01, P = 0.015). The DC values of the right inferior temporal area were positively correlated with the pain degree at TP1 in Group 1 (r = 0.371; P = 0.008). Conclusion Spontaneous brain activity and network changes in young women with non-menstrual MwoA were altered by acupuncture. The right temporal area may be an important target for acupuncture modulated brain function in young women with non-menstrual MwoA.

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“…The Cho/Cr PMR was increased in our study. Previous studies have shown inconsistent results; no change in occipital lobe [11], decrease [74], increase in the occipital lobe [69]. It is difficult to compare these studies due to the small number of cases and/or the different clinical phenotypes.…”

Section: Magnetic Resonance Spectroscopic Examination (Mrs)mentioning

confidence: 95%

A Study of the Functional, Metabolic and Microstructural Brain Changes in Patients with Migraine without Aura

Ebrahim,

Rabee,

Elshamy

et al. 2023

JAMMR

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Background: Migraine is a very common disease. Studying the pathological changes in the brain is important for understanding the mechanisms underlying migraine headache. Previous research work has given conflicting results. This study aimed to investigate the functional, metabolic and microstructural changes in the brain of migraine patients without aura. Methods: This study included 42 migraine patients without aura in the interictal period and 11 age and sex matched controls. All participants were subjected to clinical assessment, assessment of the habituation to visual evoked potentials, assessment of the peak metabolic ratios by H-MRS and diffusion tensor imaging of the brain to test for regional microstructural changes. Results: The amplitudes of VEPs showed significant reduction in control subjects (P < 0.01), but not in migraine patients after repeated stimulation and significant increase in migraine patients compared to controls (P < 0.01). H-MRS showed significant decrease of NAA/Cr (P < 0.01) and increase of Mi/NAA (P < 0.001) and Cho/Cr (P < 0.05) PMRs in the thalamus and occipital lobes in migraine patients compared to controls. DTI showed significant changes in the FA, AD, MD, RD values in the thalamus, occipital lobe and insula in migraine patients indicating microstructural changes in these areas. All changes showed significant correlation with the intensity, frequency and duration of migraine episodes, but not with the duration of migraine disease. Conclusion: Migraine patients without aura showed increased excitability to visual stimulation and significant metabolite and microstructural brain changes that correlated with the severity, not the duration of the disease. These changes need to be confirmed in a large scale longitudinal studies.

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Altered Metabolites in the Occipital Lobe in Migraine Without Aura During the Attack and the Interictal Period

Cited by 12 publications

References 49 publications

Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study

Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study

Modulation of temporal and occipital cortex by acupuncture in non- menstrual MWoA patients: A Rest Bold fMRI study

A Study of the Functional, Metabolic and Microstructural Brain Changes in Patients with Migraine without Aura

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