Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging
Nicholas R W Cleland,
Garrett J Potter,
Courtney Buck
et al.
Abstract:Despite Alzheimer’s disease (AD) disproportionately affecting women, the mechanisms remain elusive. In AD, microglia undergo ‘metabolic reprogramming’, which contributes to microglial dysfunction and AD pathology. However, how sex and age contribute to metabolic reprogramming in microglia is understudied. Here, we use metabolic imaging, transcriptomics, and metabolic assays to probe age-and sex-associated changes in brain and microglial metabolism. Glycolytic and oxidative metabolism in the whole brain was det… Show more
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