Altered maternal proportions of long chain polyunsaturated fatty acids and their transport leads to disturbed fetal stores in preeclampsia

Wadhwani, Nisha; Patil, Vidya; Pisal, Hemlata; Joshi, Anuradha Rajiv; Mehendale, Savita; Gupte, Sanjay; Wagh, Girija; Joshi, Sadhana

doi:10.1016/j.plefa.2014.05.006

Cited by 64 publications

(39 citation statements)

References 58 publications

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“…We have previously reported lower proportions of AA and DHA in maternal plasma during the 16th–20th weeks of gestation in pregnancies that progressed to PE as compared with normotensive pregnancies. Furthermore, the maternal DHA and AA levels at this time point were positively associated with their levels in the placenta and cord blood . We and others have demonstrated lower DHA and total omega 3 fatty acid levels in the PE placenta as compared with normotensive placenta …”

Section: Introductionsupporting

confidence: 60%

Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Rani

Wadhwani

Chavan‐Gautam

et al. 2016

WIREs Developmental Biology

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The placenta is an essential organ formed during pregnancy that mainly transfers nutrients from the mother to the fetus. Nutrients taken up by the placenta are required for its own growth and development and to optimize fetal growth. Hence, placental function is an important determinant of pregnancy outcome. Among various nutrients, fatty acids, especially long-chain polyunsaturated fatty acids (LCPUFAs), including omega 3 and omega 6 fatty acids, are essential for placental development from the time of implantation. Studies have associated these LCPUFAs with placental development through their roles in regulating oxidative stress, angiogenesis, and inflammation, which may in turn influence their transfer to the fetus. The placenta has a heterogeneous morphology with variable regional vasculature, oxidative stress, and LCPUFA levels in healthy pregnancies depending upon the location within the placenta. However, these regional structural and functional parameters are found to be disturbed in pathological conditions, such as preeclampsia (PE), thereby affecting pregnancy outcome. Hence, the alterations in LCPUFA metabolism and transport in different regions of the PE placenta as compared with normal placenta could potentially be contributing to the pathological features of PE. The regional variations in development and function of the placenta and its possible association with placental LCPUFA metabolism and transport in normal and PE pregnancies are discussed in this review. WIREs Dev Biol 2016, 5:582-597. doi: 10.1002/wdev.238 For further resources related to this article, please visit the WIREs website.

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Section: Introductionsupporting

confidence: 60%

Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Rani

Wadhwani

Chavan‐Gautam

et al. 2016

WIREs Developmental Biology

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“…In contrary, Kulkarni et al, demonstrated increased levels of arachidonic acid and decreased levels of docosahexaenoic acid in the placenta of preeclamptic women, similar to the outcome of this study [13]. Also, Wadhwani et al presented the lower proportions of DHA in the placental tissues of preeclamptic pregnancy like this study [14]. Because the levels of FAs can be affected dietary pattern, the subjects in this study were specifically matched with the gestational age at delivery, normal neonatal body weight without intrauterine growth restriction, BMI before pregnancy, similar parameters of life style and food intake.…”

Section: Ffa Compositions In Placental Tissues Of Normal and Preeclamsupporting

confidence: 84%

Metabolomic Study on Fatty Acids in Placenta of Preeclamptic Pregnancies by Gas Chromatography-Mass Spectrometry

Paik¹,

Shim²,

Seo³

et al. 2017

J Chromatogr Sep Tech

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“…The umbilical cord blood was also collected just after delivery of the baby (T4). The detailed study design has been described by us earlier (Wadhwani et al, 2014; Sahay et al, 2015).…”

Section: Methodsmentioning

confidence: 99%

Maternal nerve growth factor levels during pregnancy in women with preeclampsia: A longitudinal study

D'Souza

Kilari

Pisal

et al. 2015

Intl J of Devlp Neuroscience

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Preeclampsia (PE) is characterized by hypertension and proteinuria. Improper development of the placenta due to altered angiogenesis is the main culprit in PE. Nerve growth factor (NGF) is an angiogenic factor which is expressed and localized in the placenta. Our earlier cross sectional study has shown altered NGF levels at delivery in women with PE. However, there are no studies on NGF levels in PE early in pregnancy before manifestation of the disease. Thus, there is a need to examine the role of NGF in vascular development during different stages of gestation in PE. A longitudinal study was carried out where pregnant women were enrolled from two major hospitals from Pune, Bharati hospital and Gupte hospital. They were followed at three different time points [16-20 weeks (T1), 26-30 weeks (T2) and at delivery (T3)] during pregnancy and maternal blood at every time point and cord blood at delivery was collected and processed. This study included normotensive women (n=88) and women with PE (n=48). NGF levels were measured from maternal and cord plasma using the Emax Immuno Assay System (Promega). The data was analyzed using the SPSS/PC+ package (Version 20.0, Chicago, IL, USA). Maternal NGF levels did not change at all time points while cord NGF levels were higher (p<0.05) in women with PE. Further, maternal NGF levels were negatively associated with blood pressure while cord NGF levels were positively associated with baby head circumference. Our data suggests that there may possibly be a compensatory role for NGF in the foeto-placental circulation in PE.

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Altered maternal proportions of long chain polyunsaturated fatty acids and their transport leads to disturbed fetal stores in preeclampsia

Cited by 64 publications

References 58 publications

Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Altered development and function of the placental regions in preeclampsia and its association with long‐chain polyunsaturated fatty acids

Metabolomic Study on Fatty Acids in Placenta of Preeclamptic Pregnancies by Gas Chromatography-Mass Spectrometry

Maternal nerve growth factor levels during pregnancy in women with preeclampsia: A longitudinal study

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