Altered longitudinal trajectory of default mode network connectivity in healthy youth with subclinical depressive and posttraumatic stress symptoms

J, Son; Schantell, Mikki; Picci, Giorgia; Wang, Yuping; Stephen, Julia M.; Calhoun, Vince D.; Doucet, Gaëlle E.; Taylor, Brittany K.; Wilson, Tony W.

doi:10.1016/j.dcn.2023.101216

Cited by 8 publications

(4 citation statements)

References 104 publications

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“…Specifically, DMN efficiency at rest is positively correlated with depressive symptoms and risk ( Provenzano et al, 2021 ). Another study investigated how subthreshold depression symptoms affected DMN functional connectivity during the transition period of adolescence, and the results showed that, more severe depressive symptoms were associated with significant decreases in connectivity over time, indicating that StD symptoms alter the trajectory of DMN connectivity ( Son et al, 2023 ). Another study, which used independent component analysis to investigate the functional connectivity changes of the resting DMN in two different age groups of StD patients, showed a significant increase in functional connectivity(FC) between DMN and the ventral striatum in StD patients compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Brain network hierarchy reorganization in subthreshold depression

Yin,

Yang,

Xiang

et al. 2024

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 99%

Brain network hierarchy reorganization in subthreshold depression

Yin,

Yang,

Xiang

et al. 2024

NeuroImage: Clinical

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“…Therefore, the DMN plays an important role in the regulation of mental health under stress. Longitudinal fMRI studies in adolescents have found that subclinical depression and post-traumatic symptoms alter the trajectory of DMN connections, which may indicate that the network is a clinically considerable link in mental health disorders [ 28 ]. The dynamic model of thought-roaming suggests that overactivity of the DMN (including the mPFC and PCC) in the default network core leads to automatic constraints on thought increase; this leads to rumination and obsessive thinking, which are characteristic of mood and anxiety disorders [ 25 ].…”

Section: Meaning-making Strategy Promotes Stress-related Growthmentioning

confidence: 99%

The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study

Chen

Zhu

et al. 2023

Behav Brain Funct

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Background Stressful events and meaning-making toward them play an important role in adolescents’ life and growth. However, ignoring positive stressful events leads to negativity bias; further, the neural mechanisms of meaning-making are unclear. We aimed to verify the mediating role of meaning-making in stressful events and stress-related growth and the function of the default mode network (DMN) during meaning-making in this functional magnetic resonance imaging (fMRI) study. Methods Participants comprised 59 university students. Stressful life events, meaning-making, and stress-related growth were assessed at baseline, followed by fMRI scanning during a meaning-making task aroused by mental simulation. General linear modeling and psychophysiological interaction (PPI) analyses were used to explore the activation and functional connectivity of DMN during meaning-making. Results Mental simulation triggered meaning-making, and DMN activity decreased during meaning-making. Activation of the DMN was negatively correlated with coping flexibility, an indicator of stress-related growth. PPI analysis showed that meaning-making was accompanied by diminished connectivity in the DMN. DMN activation during meaning-making can mediate the relationship between positive stressful events and coping flexibility. Conclusions Decreased DMN activity and diminished functional connectivity in the DMN occurred during meaning-making. Activation of the DMN during meaning-making could mediate the relationship between positive stressful events and stress-related growth, which provides a cognitive neural basis for the mediating role of meaning-making in the relationship between stressful events and indicators of stress-related growth. Implications This study supports the idea that prosperity makes heroes, expands the meaning-making model, and suggests the inclusion of enhancing personal resources and meaning-making in education. This study was the first to validate the activation pattern and functional connectivity of the DMN during meaning-making aroused by mental simulation using an fMRI task-state examination, which can enhance our sense of meaning and provide knowledge that can be used in clinical psychology interventions. Trial Registration The study protocol was pre-registered in Open Science Framework (see osf.io/ahm6e for details).

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“…Adolescence is crucial for psychological growth and is affected by negative events in families, schools, and physical and psychological aspects ( 5 ). These events can directly impact depressive emotions and indirectly influence the emotions by affecting ruminant thinking ( 6 ), particularly in individuals with disruptions to default mode network functional connectivity ( 7 ). However, the precise neural mechanisms underlying these changes remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Brain alterations in adolescents with first-episode depression who have experienced adverse events: evidence from resting-state functional magnetic resonance imaging

Xia,

Tang,

Peng

et al. 2024

Front. Psychiatry

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IntroductionAdverse life events constitute primary risk factors for major depressive disorder (MDD), influencing brain function and structure. Adolescents, with their brains undergoing continuous development, are particularly susceptible to enduring impacts of adverse events.MethodsWe investigated differences and correlations among childhood trauma, negative life events, and alterations of brain function in adolescents with first-episode MDD. The study included 23 patients with MDD and 19 healthy controls, aged 10–19 years. All participants underwent resting-state functional magnetic resonance imaging and were assessed using the beck depression inventory, childhood trauma questionnaire, and adolescent self-rating life events checklist.ResultsCompared with healthy controls, participants with first-episode MDD were more likely to have experienced emotional abuse, physical neglect, interpersonal relationship problems, and learning stress (all p’ < 0.05). These adverse life events were significantly correlated with alterations in brain functions (all p < 0.05).DiscussionThis study contributes novel evidence on the underlying process between adverse life events, brain function, and depression, emphasizing the significant neurophysiological impact of environmental factors.

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Altered longitudinal trajectory of default mode network connectivity in healthy youth with subclinical depressive and posttraumatic stress symptoms

Cited by 8 publications

References 104 publications

Brain network hierarchy reorganization in subthreshold depression

Brain network hierarchy reorganization in subthreshold depression

The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study

Brain alterations in adolescents with first-episode depression who have experienced adverse events: evidence from resting-state functional magnetic resonance imaging

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