Altered long-range alpha-band synchronization during visual short-term memory retention in children born very preterm

Doesburg, Sam M.; Ribary, Urs; Herdman, Anthony T.; Miller, Steven P.; Poskitt, Kenneth J.; Moiseev, Alexander A.; Whitfield, Michael F.; Synnes, Anne; Grunau, Ruth E.

doi:10.1016/j.neuroimage.2010.10.044

Cited by 57 publications

(76 citation statements)

References 75 publications

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“…Multiple studies across the past decade suggest that alterations in neural networks contribute to the cognitive and behavioral difficulties of the prematurely-born (Doesburg et al, 2011; Ment et al, 2009; Myers et al, 2010; Nosarti, 2013; Salvan et al, 2013), but recent reports demonstrate alterations in the genetically-determined process of cerebral lateralization in PT subjects at adolescence and young adulthood (Scheinost et al, 2014; Wilke et al, 2014). Lateralization implies localization of a cognitive task to a specific cerebral region, and lateralization of language is a critical characteristic of developing brain (Power et al, 2010; Renteria, 2012).…”

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confidence: 99%

Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born

et al. 2015

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Preterm birth results in alterations in neural connectivity, but the impact of prematurity on the functional organization of the developing brain has yet to be explored. To test the hypothesis that preterm birth alters cortical organization during the late second and third trimesters of gestation, we interrogated cerebral lateralization at rest in 26 very preterm subjects (birth weight 500–1500 g) with no evidence of brain injury and 25 healthy term control subjects at term equivalent age. Employing an unbiased voxel-based measure of functional connectivity, these data demonstrated that cerebral lateralization is impaired in the prematurely-born. At term equivalent age, preterm neonates showed significantly less lateralization in regions subserving both receptive and expressive language, left Brodmann (BA) areas insula-BA22-BA21 and L BA45-BA47 (p<0.05 corrected for multiple comparisons for both). Exploratory region of interest analyses demonstrated significantly less inter-hemispheric connectivity from L BA22 to R BA22 in preterm infants compared to term controls (p<0.005) and from R BA22 to its homolog (p<0.005). L BA22, Wernicke’s area, was more strongly connected to R BA39, foreshadowing neural networks for language in preterm subjects at school age, adolescence and young adulthood. For these very preterm neonates born at less than 30 weeks PMA, the degree of prematurity had no influence on lateralization in these differential regions.

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Section: Introductionmentioning

confidence: 99%

Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born

et al. 2015

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“…Additionally, the rate of change in cortical surface area between 24 and 44 weeks postmenstrual age predicts cognitive ability at 2 and 6 years corrected age in children born very preterm (18). At age 7 years, children born preterm demonstrate altered cortical connectivity (19) and synchronization during cognitive tasks relative to full-term controls, even in the absence of major disability (20). However, the etiology for their altered cortical development and processing remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Slower Postnatal Growth Is Associated with Delayed Cerebral Cortical Maturation in Preterm Newborns

et al. 2013

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Slower postnatal growth is an important predictor of adverse neurodevelopmental outcomes in infants born preterm. However, the relationship between postnatal growth and cortical development remains largely unknown. Therefore, we examined the association between neonatal growth and diffusion tensor imaging measures of microstructural cortical development in infants born very preterm. Participants were 95 neonates born between 24 and 32 weeks gestational age studied twice with diffusion tensor imaging: scan 1 at a median of 32.1 weeks (interquartile range, 30.4 to 33.6) and scan 2 at a median of 40.3 weeks (interquartile range, 38.7 to 42.7). Fractional anisotropy and eigenvalues were recorded from 15 anatomically defined cortical regions. Weight, head circumference, and length were recorded at birth and at the time of each scan. Growth between scans was examined in relation to diffusion tensor imaging measures at scans 1 and 2, accounting for gestational age, birth weight, sex, postmenstrual age, known brain injury (white matter injury, intraventricular hemorrhage, and cerebellar hemorrhage), and neonatal illness (patent ductus arteriosus, days intubated, infection, and necrotizing enterocolitis). Impaired weight, length, and head growth were associated with delayed microstructural development of the cortical gray matter (fractional anisotropy: P < 0.001), but not white matter (fractional anisotropy: P = 0.529), after accounting for prenatal growth, neonatal illness, and brain injury. Avoiding growth impairment during neonatal care may allow cortical development to proceed optimally and, ultimately, may provide an opportunity to reduce neurological disabilities related to preterm birth.

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“…This broad range of disabilities is consistent with widely distributed brain abnormalities or problems with brain connectivity. 13 Preterm children with IQ in the normal range, often display processing deficits related to attention and executive functions that include cognitive flexibility, inhibitory control and working memory, 3,14,15 as well as deficits in visually-based information processing and language. 16-21 Frequently, these cognitive and behavior problems persist to young adulthood.…”

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Brain Injury in the Preterm Infant: New Horizons for Pathogenesis and Prevention

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2015

Pediatric Neurology

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Preterm neonates are surviving with a milder spectrum of motor and cognitive disabilities that appear to be related to widespread disturbances in cell maturation that target cerebral gray and white matter. Whereas the preterm brain was previously at high risk for destructive lesions, preterm survivors now commonly display less severe injury that is associated with aberrant regeneration and repair responses that result in reduced cerebral growth. Impaired cerebral white matter growth is related to myelination disturbances that are initiated by acute death of pre-myelinating oligodendrocytes (preOLs), but are followed by rapid regeneration of preOLs that fail to normally mature to myelinating cells. Although immature neurons are more resistant to cell death than mature neurons, they display widespread disturbances in maturation of their dendritic arbors and synapses, which further contributes to impaired cerebral growth. Thus, even more mild cerebral injury involves disrupted repair mechanisms in which neurons and preOLs fail to fully mature during a critical window in development of neural circuitry. These recently recognized distinct forms of cerebral gray and white matter dysmaturation raise new diagnostic challenges and suggest new therapeutic strategies to promote brain growth and repair.

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Altered long-range alpha-band synchronization during visual short-term memory retention in children born very preterm

Cited by 57 publications

References 75 publications

Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born

Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born

Slower Postnatal Growth Is Associated with Delayed Cerebral Cortical Maturation in Preterm Newborns

Brain Injury in the Preterm Infant: New Horizons for Pathogenesis and Prevention

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