Altered Long Non-coding RNAs Expression and Cytotoxic and Anti-proliferative Activity of Dendrosomal Nano-curcumin in Ovarian Cancer Cells

Hosseini, Elahe Seyed; Zarei, Marziyeh Alizadeh; Kashani, Hamed Haddad; Salimian, Morteza; Kashani, Narjes Riahi

doi:10.1007/s40944-021-00511-1

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…A separate 2021 research examined DNC′s impact on ovarian carcinoma cells′ cytokinetics, apoptosis, proliferation, and lncRNA expression. The research indicated that DNC lowered HOTAIR and H19 expression but increased MEG3 expression [119] . These studies suggest that dendrosomes may increase curcumin solubility and cellular absorption without harm.…”

Section: Nanoparticle‐mediated Lncrnas‐targeting Strategies Against C...mentioning

confidence: 82%

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Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Davodabadi,

Farasati Far,

Sargazi

et al. 2024

ChemMedChem

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This review article spotlights the burgeoning potential of using nanotherapeutic strategies to target long non‐coding RNAs (lncRNAs) in cancer cells. This updated discourse underlines the prominent role of lncRNAs in instigating cancer, facilitating its progression, and metastasis, validating lncRNAs' potential for being effective diagnostic biomarkers and therapeutic targets. The manuscript offers an in‐depth examination of different strategies presently employed to modulate lncRNA expression and function for therapeutic purposes. Among these strategies, Antisense Oligonucleotides (ASOs), RNA interference (RNAi) technologies, and the innovative CRISPR‐based gene editing tools garner noteworthy mention. A significant section of the review is dedicated to nanocarriers and their crucial role in drug delivery. These nanocarriers' efficiency in targeting lncRNAs in varied types of cancers is elaborated upon, validating the importance of targeted therapy. The manuscript culminates by reaffirming the promising prospects of targeting lncRNAs to enhance the accuracy of cancer diagnosis and improve treatment efficacy. Consequently, new paths are opened to more research and innovation in employing nanotherapeutic approaches against lncRNAs in cancer cells. Thus, this comprehensive manuscript serves as a valuable resource that underscores the vital role of lncRNAs and the various nano‐strategies for targeting them in cancer treatment.

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Section: Nanoparticle‐mediated Lncrnas‐targeting Strategies Against C...mentioning

confidence: 82%

“…The research indicated that DNC lowered HOTAIR and H19 expression but increased MEG3 expression. [119] These studies suggest that dendrosomes may increase curcumin solubility and cellular absorption without harm. Additionally, numerous lncRNAs shape ovarian cancer cells.…”

Section: Ovarian Cancermentioning

confidence: 99%

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Davodabadi,

Farasati Far,

Sargazi

et al. 2024

ChemMedChem

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“…In vitro [57] Co-use of curcumin nanoparticles and Cisplatin Decrease of ovarian tumor weight and volume, reduction of PI3K, TGF-β, JAK, and Ki67 expression, Akt and STAT3 phosphorylation, and decrease of IL-6 level…”

Section: Type Of Nano-based Herbal Formulation Mechanism/effect In Vivo/in Vitro Referencesmentioning

confidence: 99%

The Therapeutic Potential of Common Herbal and Nano-Based Herbal Formulations against Ovarian Cancer: New Insight into the Current Evidence

et al. 2021

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Ovarian cancer (OCa) is characterized as one of the common reasons for cancer-associated death in women globally. This gynecological disorder is chiefly named the “silent killer” due to lacking an association between disease manifestations in the early stages and OCa. Because of the disease recurrence and resistance to common therapies, discovering an effective therapeutic way against the disease is a challenge. According to documents, some popular herbal formulations, such as curcumin, quercetin, and resveratrol, can serve as an anti-cancer agent through different mechanisms. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the contrary, using nano-based material, e.g., nanoparticles (NPs), micelles, liposomes, can significantly solve these limitations. Therefore, in the present study, we will summarize the anti-cancer aspects of these herbal and-nano-based herbal formulations with a focus on their mechanisms against OCa.

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“…MEG3 is a1.6 kb long non-coding RNA (lncRNA) located on chromosome 14q32.3 and consists of ten exons (13). Previous studies have illustrated that MEG3 may affect proliferation and apoptosis of tumor cells (14)(15)(16)(17)(18). However, little is known about the role of MEG3 in the development of chemo resistant in ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Oxaliplatin and Nanocurcumin in Dendrosomal Carrier to Inhibits Ovarian Cancer Cells Invasion and Metastasis Through the Long Non-Coding RNA MEG3

et al. 2022

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Altered Long Non-coding RNAs Expression and Cytotoxic and Anti-proliferative Activity of Dendrosomal Nano-curcumin in Ovarian Cancer Cells

Cited by 6 publications

References 29 publications

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

The Therapeutic Potential of Common Herbal and Nano-Based Herbal Formulations against Ovarian Cancer: New Insight into the Current Evidence

Synergistic Effect of Oxaliplatin and Nanocurcumin in Dendrosomal Carrier to Inhibits Ovarian Cancer Cells Invasion and Metastasis Through the Long Non-Coding RNA MEG3

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