Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats

Abstract

The thalamostriatal pathway is implicated in Parkinson’s disease (PD); however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex (CM/Pf, or the Pf in rodents) and the dorsal striatum (DS) remain unclear. Therefore, we simultaneously recorded local field potentials (LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band (12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta (0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition, exaggerated low gamma (35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta (3 Hz–7 Hz) and beta bands, and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha (7 Hz–12 Hz) and beta bands for two coherence measures. Collectively, dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease.

fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons

“…The glutamate levels were reported to be related to the gamma bands (Lally et al, 2014), while the effect of the dopaminergic and cholinergic neurons has been observed on low frequency fluctuation of LFP (Neske, 11 2016). The delta power of LFP in the ipsilateral DS was reduced by the disruption of dopamine in the resting state (Zhang et al, 2018). Although the mechanism of delta power increase in the ipsilateral DS is not clear, the change of dopaminergic or cholinergic neurons activation following the activation of striatal neurons may induce this delta power increase.…”

Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons

“…Abnormal functions of the striatum are closely associated with Huntington's disease and Parkinson's disease [2][3][4]. The striatum can be divided into the dorsal and ventral parts [2,5]. The dorsal striatum comprises the caudate nucleus and putamen, while the ventral striatum includes the nucleus accumbens and olfactory tubercles [6].…”

2 Hz EA Reduces Heroin Withdrawal-Induced Hyperalgesia and Heroin Relapse by Downregulating P2X3 Receptors in DRG Neurons

“…e animals were maintained under a 12 h reversed light/dark cycle (with darkness starting from 8:00 am) with controlled room temperature and humidity. Tap water was made available ad libitum, and food was restricted to 20 g per day to keep animal weight constant [23,24]. All procedures were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and with the approval of Animal Care and Use Committee of Jianghan University.…”