Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study

Zhang, Di; Huang, Xiaobin; Su, Wen; Chen, Yu‐Chen; Wang, Peng; Mao, Cunnan; Miao, Zhengfei; Liu, Chunmei; Xu, Chenjie; Yin, Xindao; Wu, Xinying

doi:10.1186/s10194-020-01086-6

Cited by 26 publications

(28 citation statements)

References 43 publications

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“…The growing amount of literature suggests that the hyper-excitable or hyper-connected lingual gyrus has been implicated with visual disturbances of migraineurs such as blurred vision, photophobia, or visual aura. 42 , 46 For example, resting-state FC between the right lingual gyrus and cerebellum was linked to visual light sensitivity in MwoA. 46 Interestingly, dopaminergic reward network has been hypothesized mechanisms underlying the auditory and visual hallucination of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“… 42 , 46 For example, resting-state FC between the right lingual gyrus and cerebellum was linked to visual light sensitivity in MwoA. 46 Interestingly, dopaminergic reward network has been hypothesized mechanisms underlying the auditory and visual hallucination of schizophrenia. 47 Moreover, NAc activation was related to its vividness.…”

Section: Discussionmentioning

confidence: 99%

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Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Kim¹,

Jassar²,

Lim³

et al. 2021

JPR

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Purpose It has been suggested that reward system dysfunction may account for emotion and pain suffering in migraine. However, there is a lack of evidence whether the altered reward system connectivity is directly associated with clinical manifestations, including negative affect and ictal pain severity and, at the molecular level, the dopamine (DA) D2/D3 receptors (D2/3Rs) signaling implicated in encoding motivational and emotional cues. Patients and Methods We acquired resting-state functional MRI from interictal episodic migraine (EM) patients and age-matched healthy controls, as well as positron emission tomography (PET) with [ 11 C]raclopride, a selective radiotracer for DA D2/3Rs, from a subset of these participants. The nucleus accumbens (NAc) was seeded to measure functional connectivity (FC) and DA D2/3Rs availability based on its essential involvement in pain-related aversive/reward functions. Associations of the brain measures with positive/negative affect and ictal pain severity were also assessed. Results Compared with controls, the EM group showed weaker right NAc connectivity with areas implicated in pain and emotional regulation, such as the amygdala, rostral anterior cingulate cortex, hippocampus, and thalamus; but showed stronger left NAc connectivity with the dorsolateral prefrontal cortex and lingual gyrus. Moreover, among the altered NAc connectivities, only right NAc-amygdala connectivity was inversely correlated with DA D2/3Rs availability in migraine patients (diagnostic group-by-D2/3Rs interaction p < 0.007). At a clinical level, such weaker NAc-amygdala connectivity was associated with lower interictal positive affect and greater ictal pain severity over the head and facial extension area (pain area and intensity number summation, PAINS). Conclusion Together, our findings suggest that altered reward system connectivity, specifically between the NAc and amygdala, might be affected by endogenous DA D2/3Rs signaling, and such process might be a neural mechanism that underlies emotional and pain suffering in episodic migraineurs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Kim¹,

Jassar²,

Lim³

et al. 2021

JPR

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“…In migraine, mechanisms likely involve hypersensitivity of the intrinsically photosensitive retinal ganglion cells that may project to pain processing regions of the thalamus, and hypersensitivity, structural remodeling, and altered functional connectivity of visual processing regions in the brain. [26][27][28][29] Functional and structural brain imaging studies in PPTH are required to determine if there are similar findings in PPTH. Furthermore, photosensitivity is considered a relatively common symptom of mTBI, even in the absence of PTH.…”

Section: Discussionmentioning

confidence: 99%

Sensory hypersensitivities in those with persistent post-traumatic headache versus migraine

Hanna

Chong

Dumkrieger

et al. 2020

Cephalalgia Reports

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Background and Objective: Symptoms of persistent post-traumatic headache (PPTH) most often resemble those of migraine, including the presence of photo-, phono-, and cutaneous hypersensitivities. The severity of these hypersensitivity symptoms in those with PPTH compared to those with migraine has yet to be fully elucidated. The objective of this study was to compare symptoms of sensory hypersensitivities between PPTH, migraine, and healthy controls (HCs). Further defining characteristics of PPTH and its similarities to migraine might assist with developing future diagnostic criteria for PPTH and provide insights into PPTH mechanisms. Methods: This analysis included 56 individuals with PPTH attributed to mild traumatic brain injury, 30 with migraine, and 36 HCs. To assess sensory hypersensitivities, all subjects completed the Allodynia Symptom Checklist-12, the Photosensitivity Assessment Questionnaire, and the Hyperacusis Questionnaire. Differences among groups were assessed using Fisher’s exact test, Kruskal–Wallis, or Mann–Whitney U test. Results: PPTH and migraine groups had greater severity of cutaneous, photo-, and phono-hypersensitivity symptoms compared to HCs. There were no statistically significant differences between the PPTH and migraine groups for cutaneous allodynia (median [first quartile, third quartile]; PPTH: 4.0 [2.0, 7.0]; migraine: 5.0 [3.0, 8.0]; p = 0.54) or photosensitivity severity (PPTH: 5.0 [2.0, 7.0]; migraine: 5.0 [2.0, 6.0]; p = 0.53). Those with PPTH had higher hyperacusis scores compared to those with migraine (PPTH: 23.0 [17.0, 31.0]; migraine: 13.5 [9.0, 24.0]; p = 0.001). Conclusion: Sensory hypersensitivity symptoms among individuals with PPTH are at least as severe as those experienced by people with migraine. Results further confirm symptom similarities between PPTH and migraine and could suggest that PPTH and migraine have a partially shared underlying pathophysiology.

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“…A possible explanatory mechanism is the excessive lateral inhibition within the visual cortex [ 36 ]. However, the complexity of the non-linear properties of visual cortex responses could be explained by both cortical and subcortical pathways [ 23 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…The response to visual stimuli depends on the inhibitory/excitatory balance through the cortical network and may comprehend subcortical diencephalic relays pathways [ 23 ]. VEP allows measuring the summation of the electrical activity of the occipital region, where the visual cortex resides, in response to the presented stimulus and contrast gain.…”

Section: Introductionmentioning

confidence: 99%

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

Luca

Gori

Mazzucchi

et al. 2021

JCM

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Migraine is a primary headache with high prevalence among the general population, characterized by functional hypersensitivity to both exogenous and endogenous stimuli particularly affecting the nociceptive system. The hyperresponsivity of cortical neurons could be due to a disequilibrium in the excitatory/inhibitory signaling. This study aimed to investigate the anatomo-functional pathway from the retina to the primary visual cortex using visual evoked potentials (VEP). Contrast gain protocol was used in 15 patients diagnosed with migraine without aura (at baseline and after 3 months of topiramate therapy) and 13 controls. A saturation (S) index was assessed to monitor the response of VEP’s amplitude to contrast gain. Non-linear nor monotone growth of VEP (S < 0.95) was defined as supersaturation. A greater percentage of migraine patients (53%) relative to controls (7%) showed this characteristic. A strong inverse correlation was found between the S index and the number of days separating the registration of VEP from the next migraine attack. Moreover, allodynia measured through the Allodynia Symptoms Check-list (ASC-12) correlates with the S index both at baseline and after 3 months of topiramate treatment. Other clinical characteristics were not related to supersaturation. Topiramate therapy, although effective, did not influence electrophysiological parameters suggesting a non-intracortical nor retinal origin of the supersaturation (with possible involvement of relay cells from the lateral geniculate nucleus). In conclusion, the elaboration of visual stimuli and visual cortex activity is different in migraine patients compared to controls. More data are necessary to confirm the potential use of the S index as a biomarker for the migraine cycle (association with the pain-phase) and cortical sensitization (allodynia).

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Altered lateral geniculate nucleus functional connectivity in migraine without aura: a resting-state functional MRI study

Cited by 26 publications

References 43 publications

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine

Sensory hypersensitivities in those with persistent post-traumatic headache versus migraine

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

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