Altered isozyme patterns of leucocyte alkaline phosphatase in disease states

Miller, Donald M.; Yang, Angela; Liepman, Michael R.

doi:10.1111/j.1365-2141.1984.tb08508.x

Cited by 4 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The blood samples examined were obtained in the chronic stable phase of the disease. This result is in agreement with the studies referring to NAP isoenzyme patterns in CGL by Miller et al [7], According to the histochemical and biochemical criteria, we may conclude that the patient's cells do contain two unequally distributed ALP isoenzymes: (1) a large amount of an unstable component with properties very similar to those of the non-Regan vari ant. This isoenzyme has been described in various hu man tumors, in cultured cancer cells [3][4][5]12], and in normal human first-trimester placentas [11].…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Changes in Neutrophil Alkaline Phosphatase Patterns in a Case of Chronic Myelomonocytic Leukemia

Vergnes¹,

Grozdea²,

Laharrague³

et al. 1985

Acta Haematol

View full text Add to dashboard Cite

In neutrophils from a 75-year-old woman suffering from chronic leukemia, an abnormal alkaline phosphatase (ALP) was observed, characterized by a significant increase in neutrophil alkaline phosphatase (NAP) activity, associated with an ectopic expression of two isoenzymes: a thermolabile ALP similar to the early placental form (or non-Regan variant), and a heat-stable isoenzyme closely related to the Nagao isoenzyme. The presence of these oncodevelopmental NAP isoenzymes in a myeloproliferative syndrome has previously not been reported.

show abstract

Section: Discussionsupporting

confidence: 82%

“…Very recently Miller el al. [7] demonstrated the presence of a fast-moving band in neutrophil al kaline phosphatase (NAP) zymograms in blast cells from CGL patients with elevated NAP scores. The present study deals with the characterization of the iso enzymes expressed in neutrophils from a patient suffering from chronic myelomonocytic leukemia.…”

mentioning

confidence: 99%