Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study

Huang, Xin; Li, Shenghong; Zhou, Fuqing; Zhang, Ying; Zhong, Yuan; Cai, Fengqin; Shao, Yi; Zeng, Xianjun

doi:10.2147/ndt.s105478

Cited by 33 publications

(22 citation statements)

References 39 publications

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“…The functional images were analyzed as described previously. 18 Briefly, the data were filtered by software and preprocessed using Statistical Parametric Mapping SPM8 (The MathWorks, Inc., Natick, MA, USA) and Data Processing Assistant for rs-fMRI DPARSFA (Institute of Psychology, CAS., Beijing, People’s Republic of China) software. 19 The first 10 volumes of each subject were discarded because of the signal reaching equilibrium.…”

Section: Methodsmentioning

confidence: 99%

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Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study

Huang¹,

Li²,

Li³

et al. 2017

NDT

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ObjectiveThe aim of the study was to investigate changes of brain neural homogeneity in retinal detachment (RD) patients using the regional homogeneity (ReHo) method to understand their relationships with clinical features.Materials and methodsA total of 30 patients with RD (16 men and 14 women), and 30 healthy controls (HCs) (16 men and 14 women) closely matched in age and sex were recruited. Resting-state functional magnetic resonance imaging scans were performed for all subjects. The ReHo method was used to investigate the brain regional neural homogeneity. Patients with RD were distinguished from HCs by receiver operating characteristic curve. The relationships between the mean ReHo signal values in many brain regions and clinical features in RD patients were calculated by Pearson correlation analysis.ResultsCompared with HCs, RD patients had significantly decreased ReHo values in the right occipital lobe, right superior temporal gyrus, bilateral cuneus and left middle frontal gyrus. Moreover, we found that the mean ReHo signal of the bilateral cuneus showed positive relationships with the duration of the RD (r=0.392, P=0.032).ConclusionThe RD patients showed brain neural homogeneity dysfunction in the visual pathway, which may underline the pathological mechanism of RD patients with acute vision loss. Besides, the ReHo values can reflect the progress of the RD disease.

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Section: Methodsmentioning

confidence: 99%

“…In our previous studies, the ReHo method has been successfully used to assess the neurological conditions in some eye diseases such as optic neuritis 17 and comitant strabismus. 18 …”

Section: Introductionmentioning

confidence: 99%

Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study

Huang¹,

Li²,

Li³

et al. 2017

NDT

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“…Presumably, these latter regions are involved in visuomotor action and visuospatial attention, among other functions, which appear to be impaired in amblyopes ( Niechwiej-Szwedo et al, 2012 , Niechwiej-Szwedo et al, 2014 ). Two similar studies have now examined subjects with strabismic amblyopia and also find multiple sites of abnormality including lingual and inferior temporal cortex, as well as cerebellum, angular and cingulate and medial frontal cortex ( Huang et al, 2016 ; Tan et al, 2016 ). While these wide-ranging cortical effects are likely to result from the chronically impaired visual input experienced in visual cortex, none of these studies have actually defined the functional boundaries of individual visual areas or evaluated the connectivity between them.…”

Section: Introductionmentioning

confidence: 93%

Partial correlation analysis reveals abnormal retinotopically organized functional connectivity of visual areas in amblyopia

Mendola

Lam

Rosenstein

et al. 2018

NeuroImage: Clinical

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Amblyopia is a prevalent developmental visual disorder of childhood that typically persists in adults. Due to altered visual experience during critical periods of youth, the structure and function of adult visual cortex is abnormal. In addition to substantial deficits shown with task-based fMRI, previous studies have used resting state measures to demonstrate altered long-range connectivity in amblyopia. This is the first study in amblyopia to analyze connectivity between regions of interest that are smaller than a single cortical area and to apply partial correlation analysis to reduce network effects. We specifically assess short-range connectivity between retinotopically defined regions of interest within the occipital lobe of 8 subjects with amblyopia and 7 subjects with normal vision (aged 19–45). The representations of visual areas V1, V2, and V3 within each of the four quadrants of visual space were further subdivided into three regions based on maps of visual field eccentricity. Connectivity between pairs of all nine regions of interest in each quadrant was tested via correlation and partial correlation for both groups. Only the tests of partial correlation, i.e., correlation between time courses of two regions following the regression of time courses from all other regions, yielded significant differences between resting state functional connectivity in amblyopic and normal subjects. Subjects with amblyopia showed significantly higher partial correlation between para-foveal and more eccentric representations within V1, and this effect associated with poor acuity of the worse eye. In addition, we observed reduced correlation in amblyopic subjects between isoeccentricity regions in V1 and V2, and separately, between such regions in V2 and V3. We conclude that partial correlation-based connectivity is altered in an eccentricity-dependent pattern in visual field maps of amblyopic patients. Moreover, results are consistent with known clinical and psychophysical vision loss. More broadly, this provides evidence that abnormal cortical adaptations to disease may be better isolated with tests of partial correlation connectivity than with the regular correlation techniques that are currently widely used.

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“… 20 Another ReHo study demonstrated that persistent somatoform pain disorder was associated with dysfunction of brain activity in many regions. 21 In our previous studies, the ReHo method was successfully used to assess synchronous neural activities in some eye diseases such as optic neuritis, 22 comitant strabismus, 23 and acute open-globe injury. 24 …”

Section: Introductionmentioning

confidence: 99%

Assessment of synchronous neural activities revealed by regional homogeneity in individuals with acute eye pain: a resting-state functional magnetic resonance imaging study

Tang

Huang

et al. 2018

JPR

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ObjectivePrevious neuroimaging studies have demonstrated that pain-related diseases are associated with brain function and anatomical abnormalities, whereas altered synchronous neural activity in acute eye pain (EP) patients has not been investigated. The purpose of this study was to explore whether or not synchronous neural activity changes were measured with the regional homogeneity (ReHo) method in acute EP patients.MethodsA total of 20 patients (15 males and 5 females) with EP and 20 healthy controls (HCs) consisting of 15 and 5 age-, sex-, and education-matched males and females, respectively, underwent resting-state functional magnetic resonance imaging. The ReHo method was applied to assess synchronous neural activity changes.ResultsCompared with HCs, acute EP patients had significantly lower ReHo values in the left precentral/postcentral gyrus (Brodmann area [BA]3/4), right precentral/postcentral gyrus (BA3/4), and left middle frontal gyrus (BA6). In contrast, higher ReHo values in acute EP patients were observed in the left superior frontal gyrus (BA11), right inferior parietal lobule (BA39/40), and left precuneus (BA7). However, no relationship was found between the mean ReHo signal values of the different areas and clinical manifestations, which included both the duration and degree of pain in EP patients.ConclusionOur study highlighted that acute EP patients showed altered synchronous neural activities in many brain regions, including somatosensory regions. These findings might provide useful information for exploration of the neural mechanisms underlying acute EP.

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Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study

Cited by 33 publications

References 39 publications

Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study

Abnormal regional spontaneous neural activity in visual pathway in retinal detachment patients: a resting-state functional MRI study

Partial correlation analysis reveals abnormal retinotopically organized functional connectivity of visual areas in amblyopia

Assessment of synchronous neural activities revealed by regional homogeneity in individuals with acute eye pain: a resting-state functional magnetic resonance imaging study

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