Altered intra- and inter-regional functional connectivity of the visual cortex in individuals with peripheral vision loss due to retinitis pigmentosa

Dan, Handong; Zhou, Fuqing; Huang, Xin; Xing, Yiqiao; Shen, Yin

doi:10.1016/j.visres.2019.02.013

Cited by 15 publications

(21 citation statements)

References 54 publications

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“…47 Disrupted brain activity and reduced cortical volume of these areas indicating vison-related dysfunctions have been reported in previous neuroimaging studies concerning amblyopia, 15,44 glaucoma, 14,48 blindness, 49 and other vision-threatening diseases. 50,51 In TAO, Silkiss et al 3 ReHo in left MOG and visual acuity, we could further deduce that brain activity disturbance in this area might progress along with the reduced visual function. However, no significant correlation was found between neural activity changes in occipital region and QoL scores.…”

Section: Discussionmentioning

confidence: 61%

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Chen

et al. 2021

Journal of Neuroimaging

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Background and Purpose: Although ophthalmic complaints were mostly mentioned in thyroid-associated ophthalmopathy (TAO), emotional and psychological disturbances are increasingly concerned. We aimed to investigate the brain functional alteration in TAO patients by using resting-state functional MRI (rs-fMRI) with the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC) methods.Methods: Twenty-one consecutive TAO patients and 21 healthy controls (HCs) underwent rs-fMRI scans. The fALFF, ReHo, and DC values were compared between groups. Results: Compared with HCs, TAO group showed decreased fALFF values in bilateral calcarine/left lingual gyrus and left middle occipital gyrus (MOG). Moreover, TAO group had decreased ReHo values in left MOG/inferior occipital gyrus/fusiform gyrus, while increased ReHo values in bilateral middle frontal gyrus (MFG)/superior frontal gyrus (SFG) than HCs. TAO group also showed decreased DC values in bilateral postcentral gyrus (PoCG)/precentral gyrus/superior parietal lobule and supplementary motor area, and increased DC values in left SFG/MFG and MFG. In TAO patients, ReHo value in left MOG was positively correlated with visual acuity (r = 0.524, p = 0.021), while ReHo values in bilateral MFGs were negatively correlated with cognitive scores (left/right: r = -0.476/-0.527, p = 0.039/0.020). DC value in left PoCG was negatively correlated with disease duration (r = -0.492, p = 0.033). Conclusions:Our findings indicated that TAO patients had brain functional alterations in the visual network, executive control network, sensorimotor network, and attention network, which may reflect potential visual and cognitive dysfunctions. K E Y W O R D Sfractional amplitude of low-frequency fluctuation, regional homogeneity, degree centrality, restingstate fMRI, thyroid-associated ophthalmopathy edema, exophthalmos, diplopia, and impaired visual function, are mostly concerned in clinical practice. 1,2 Several treatment strategies, including anti-inflammatory therapy, rehabilitative, or decompression

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Section: Discussionmentioning

confidence: 61%

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Chen

et al. 2021

Journal of Neuroimaging

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“…In the end, in addition to find that HM may cause dysfunction of some brain regions, we also noticed that the values of regional cortical thickness of right OFC, right DLPFC and right subcallosal cortex were negatively correlated with many of clinical variables (ALM,AMT, KER1, KER2,the mean KER,the mean MFK, the refractive diopter). In recent studies Han-Dong Dan et, al in a regional homogeneity (ReHo) and FC study of retinitis pigmentosa (RP) 46 found that bilateral bilateral lingual gyrus/cerebellum posterior lobe (LGG/CPL)-left IPLshowed negative correlations with best corrected visual acuity (BCVA) in RP individuals; moreover, the ReHo values of bilateral LGG/CPL were negative correlations between the duration of RP patients, they evaluated brain activity mainly through FC and ReHo, and revealed that the corresponding brain activity of RP patients would change. In another study, Huang et al 47 found that the bilateral bilateral lingual gyrus (LIGG)/ (cerebellum anterior lobe) CAL were correlated positively with the BCVA in PR patients, they suggest that the BCVA-related primary motors and visual-motor coordination areas of the brain are impaired in RP patients.…”

Section: Relationship Between Cortical Thickness and Ophthalmic Clinimentioning

confidence: 99%

Evidence of cortical thickness reduction and disconnection in high myopia

Huang

et al. 2020

Sci Rep

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High myopia (HM) is associated with impaired long-distance vision. accumulating evidences reported that abnormal visual experience leads to dysfunction in brain activity in HM even corrected. However, whether the long-term of abnormal visual experience lead to neuroanatomical changes remain unknown, the aim at this study is to investigate the alternation of cortical surface thickness in HM patients. 82 patients with HM (HM groups), 57 healthy controls (HC groups) were recruited. All participants underwent high-resolution T1 and resting-state functional magnetic resonance imaging (MRI) scans. The cortical thickness analysis was preformed to investigate the neuroanatomical changes in HM patients using computational anatomy toolbox (CAT 12) toolbox. Compare with HCs, HM patients showed decreased the cortical surface thickness in the left middle occipital gyrus (MOG), left inferior parietal lobule (IPL), right inferior temporal gyrus (ITG), right precuneus, right primary visual area 1 (V1), right superior temporal gyrus (STG), right superior parietal lobule (SPL), right occipital pole, and right the primary motor cortex (M1), and increased to the parietal operculum (OP4) (P < 0.01, FWE-corrected), the mean cortical thickness of right orbitofrontal cortex (OFC), right dorsolateral prefrontal cortex (DLPFC) and right subcallosal cortex showed negatively correlation between clinical variables (axis length (ALM), the average macular thickness (AMT), keratometer (KER) 1, KER2, the mean KER, the mean macular fovea thickness (MFK), the refractive diopter) in HM patients. Our result mainly provided an evidence of cortical thickness reduction and disconnection in visual center and visual processing area, and cortical thickness increase in left multimodal integration region in HM patients. This may provide important significance of the study of the neural mechanism of HM.

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“…Previous studies investigating ophthalmological diseases (Table 4) revealed abnormal spontaneous FC between the V1 and other regions in patients with anisometropic amblyopia, 12 blindness, [13][14][15] glaucoma, 8,16,7,16 exotropia, 10,9 acute open globe injury, 17 and retinitis pigmentosa. 18 The FC in the left V1 and right FG, bilateral cuneus, and left precuneus was significantly decreased in the NVG group compared with that reported in the HC group ( Figure 5). Meanwhile, patients with NVG presented increased FC between the right V1 and bilateral middle frontal gyrus.…”

Section: Discussionmentioning

confidence: 65%

“…A previous study demonstrated that the FC value was increased in primary openangle glaucoma between the V1 and bilateral MFG. 1921 Moreover, studies investigating several eye diseases have observed increased activation in the frontal eye field, including retinal detachment, 26 age-related macular degeneration, 27 progressive retinitis pigmentosa, 18 and macular hole. 28 In line with these preceding results, the increased FC values between the right V1 and MFG shown in this study reflected an activation of the visual processing.…”

Section: Discussionmentioning

confidence: 99%

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study</p>

Wu¹,

Wang²,

Zhu³

et al. 2020

NDT

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The purpose was to investigate the differences in spontaneous functional connectivity (FC) of the primary visual cortex (V1) between patients with neovascular glaucoma (NVG) and healthy controls (HCs) using resting-state functional magnetic resonance imaging data. Methods: A total of 18 patients with NVG (nine males and nine females) and 18 HCs with similar age and sex background were enrolled in the study and inspected using resting-state functional magnetic resonance imaging. The differences in FC of the V1 between the two groups were compared using the independent samples t-test. We used the receiver operating characteristic (ROC) curve to compare the average FC values of NVG subjects with those of HCs. Results: FC in the left V1 and right fusiform gyrus, bilateral cuneus, and left precuneus was significantly decreased in the NVG group compared with that reported in the HC group. Meanwhile, patients with NVG presented increased FC between the right V1 and bilateral middle frontal gyrus. However, they also exhibited declining FC between the right V1 and left precuneus, and bilateral cuneus. The ROC curve analysis of each brain region indicated that the accuracy of the area under the ROC curves regarding NVG was excellent. Conclusion: NVG involves aberrant FC in the V1 in different brain areas, including the visual-related and cognitive-related regions. These findings may assist in unveiling the underlying neural mechanisms of impaired visual function in NVG.

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Altered intra- and inter-regional functional connectivity of the visual cortex in individuals with peripheral vision loss due to retinitis pigmentosa

Cited by 15 publications

References 54 publications

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Evidence of cortical thickness reduction and disconnection in high myopia

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study</p>

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