2021
DOI: 10.1053/j.gastro.2020.10.041
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Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease

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Cited by 54 publications
(88 citation statements)
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“…In both mouse models we have found that values of R squared indicated a close correlation between the expression of Ace2 and the pro-inflammatory cytokine Tnf-α. These data are in agreement with the reducing effect on ACE2 expression in the colon of IBD patients exerted by therapy with anti-TNF-α [12, 52]. Confirmation of the direct regulation of ACE2 expression exerted by TNF-α was given by the in vitro experiment on human intestinal epithelial cell line (Caco-2).…”
Section: Discussionsupporting
confidence: 86%
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“…In both mouse models we have found that values of R squared indicated a close correlation between the expression of Ace2 and the pro-inflammatory cytokine Tnf-α. These data are in agreement with the reducing effect on ACE2 expression in the colon of IBD patients exerted by therapy with anti-TNF-α [12, 52]. Confirmation of the direct regulation of ACE2 expression exerted by TNF-α was given by the in vitro experiment on human intestinal epithelial cell line (Caco-2).…”
Section: Discussionsupporting
confidence: 86%
“…The regulatory effects of pelargonidin on the intestinal ACE2 might be of relevance in the context of SARS-CoV2 infection, since high levels of ACE2 are compatible with an increased risk of SARS-CoV2 uptake by the inflamed colon [12]. Importantly, in addition to ACE2 regulation, we have shown that beneficial effects of pelargonidin might extend to a direct regulation of SARS-CoV2/ACE2 interaction.…”
Section: Discussionmentioning
confidence: 89%
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“…IBD medications, both biologic and non-biologic, did not significantly impact the expression of both genes in the uninflamed small intestine 5 . However, Potdar et al revealed that within CD, small bowel ACE2 was reduced in patients subsequently developing complicated disease and that its expression was restored in responders to biologic therapy 6 . However, there remain three major gaps in our knowledge not addressed by recent studies reporting on ACE2 expression and its association with clinical IBD.…”
Section: Introductionmentioning
confidence: 99%