Altered insula-prefrontal functional connectivity correlates to decreased vigilant attention after total sleep deprivation

Qi, Jing; Li, Bo-Zhi; Zhang, Ying; Pan, Bei; Gao, Yu‐Hong; Zhan, Hao; Liu, Yong; Shao, Yuanyuan; Zhang, Xi

doi:10.1016/j.sleep.2021.05.037

Cited by 18 publications

(12 citation statements)

References 45 publications

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“…This study is the first to investigate the relationship between changes in insular and vigilance function from largescale brain networks. Our findings suggest a rebalancing of the brain network, with an equilibrium established at a lower level, since SD impairs the cognitive function of the individual, leading to a continuous decrease in the level of vigilant attention (Borragán et al, 2019;Qi et al, 2021). However, the brain appears to compensate functionally for part of the decrease; this compensatory adaptation can offset 10.3389/fnins.2022.889009 insufficient cognitive functions (Drummond et al, 2000).…”

Section: Discussionmentioning

confidence: 80%

Altered insular functional connectivity correlates to impaired vigilant attention after sleep deprivation: A resting-state functional magnetic resonance imaging study

Dai

Chen

et al. 2022

Front. Neurosci.

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ObjectivesThis study used resting-state functional magnetic resonance imaging (rs-fMRI) scans to assess the dominant effects of 36 h total sleep deprivation (TSD) on vigilant attention and changes in the resting-state network.Materials and methodsTwenty-two healthy college students were enrolled in this study. Participants underwent two rs-fMRI scans, once in rested wakefulness (RW) and once after 36 h of TSD. We used psychomotor vigilance tasks (PVT) to measure vigilant attention. The region-of-interest to region-of-interest correlation was employed to analyze the relationship within the salience network (SN) and between other networks after 36 h of TSD. Furthermore, Pearson’s correlation analysis investigated the relationship between altered insular functional connectivity and PVT performance.ResultsAfter 36 h of TSD, participants showed significantly decreased vigilant attention. Additionally, TSD induced decreased functional connectivity between the visual and parietal regions, whereas, a significant increase was observed between the anterior cingulate cortex and insula. Moreover, changes in functional connectivity in the anterior cingulate cortex and insula showed a significant positive correlation with the response time to PVT.ConclusionOur results suggest that 36 h of TSD impaired vigilant visual attention, resulting in slower reaction times. The decrease in visual-parietal functional connectivity may be related to the decrease in the reception of information in the brain. Enhanced functional connectivity of the anterior cingulate cortex with the insula revealed that the brain network compensation occurs mainly in executive function.

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Section: Discussionmentioning

confidence: 80%

Altered insular functional connectivity correlates to impaired vigilant attention after sleep deprivation: A resting-state functional magnetic resonance imaging study

Dai

Chen

et al. 2022

Front. Neurosci.

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“… Study Subjects Methods Results Qi et al. [ 25 ] Healthy volunteers (TSD 36 h) Utilizing fMRI The FC between the insula and other brain regions is significantly altered after TSD. Li et al.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, Qi et al. chose the insula as the region of interest and assessed abnormal FC in the bilateral insula after sleep deprivation, proposing that the presence of abnormal insula-related circuits may be a neural biomarker of attention impairment after complete sleep deprivation [ 25 ]. Sleep deprivation can lead not only to morphological changes in the insula but also to changes in its FC with other brain regions.…”

Section: Discussion and Narrative Synthesismentioning

confidence: 99%

Is the insula linked to sleep? A systematic review and narrative synthesis

Wang

et al. 2022

Heliyon

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“…Previous neuroimaging studies have shown increased regional spontaneous fluctuations in visual cortex and sensorimotor cortex after SD using the amplitude of low-frequency fluctuations (ALFFs) (Cai et al, 2021), percent amplitude of fluctuation (PerAF) (Zeng et al, 2020) and regional homogeneity (ReHo) (Dai et al, 2012). Qi et al (2021) have explored the effect of SD on FC in insula, which is a core hub of VAN. They find increased FC between the insula and prefrontal cortex and ACC, and reduced FC between the insula and temporal, parietal, and occipital regions after SD. For the LN, Li et al have found that SD reduces the FC between the hippocampus and SMA, SFG, and temporal regions, and increases the FC with thalamus, using a ROI-to-voxel analysis (Chengyang et al, 2017).…”

Section: Correlations Between Temporal Variability and Clinical Varia...mentioning

confidence: 99%

Abnormal dynamic functional connectivity after sleep deprivation from temporal variability perspective

Sun

Zhao

et al. 2022

Human Brain Mapping

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Sleep deprivation (SD) is very common in modern society and regarded as a potential causal mechanism of several clinical disorders. Previous neuroimaging studies have explored the neural mechanisms of SD using magnetic resonance imaging (MRI) from static (comparing two MRI sessions [one after SD and one after resting wakefulness]) and dynamic (using repeated MRI during one night of SD) perspectives. Recent SD researches have focused on the dynamic functional brain organization during the resting-state scan. Our present study adopted a novel metric (temporal variability), which has been successfully applied to many clinical diseases, to examine the dynamic functional connectivity after SD in 55 normal young subjects. We found that sleep-deprived subjects showed increased regional-level temporal variability in largescale brain regions, and decreased regional-level temporal variability in several thalamus subregions. After SD, participants exhibited enhanced intra-network temporal variability in the default mode network (DMN) and increased inter-network temporal variability in numerous subnetwork pairs. Furthermore, we found that the internetwork temporal variability between visual network and DMN was negative related with the slowest 10% respond speed (β = À.42, p = 5.57 Â 10 À4 ) of the psychomotor vigilance test after SD following the stepwise regression analysis. In conclusion, our findings suggested that sleep-deprived subjects showed abnormal dynamic brain functional configuration, which provides new insights into the neural underpinnings of SD and contributes to our understanding of the pathophysiology of clinical disorders.

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Altered insula-prefrontal functional connectivity correlates to decreased vigilant attention after total sleep deprivation

Cited by 18 publications

References 45 publications

Altered insular functional connectivity correlates to impaired vigilant attention after sleep deprivation: A resting-state functional magnetic resonance imaging study

Altered insular functional connectivity correlates to impaired vigilant attention after sleep deprivation: A resting-state functional magnetic resonance imaging study

Is the insula linked to sleep? A systematic review and narrative synthesis

Abnormal dynamic functional connectivity after sleep deprivation from temporal variability perspective

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