Altered inhibition of motor responses in Tourette Syndrome and Obsessive-Compulsive Disorder

Johannes, Sönke; Wieringa, Bernardina M.; Mantey, M.; Nager, Wido; Rada, D.; Müller‐Vahl, Kirsten; Emrich, H. M.; Dengler, Reinhard; Münte, Thomas F.; Dietrich, Detlef E.

doi:10.1034/j.1600-0404.2001.00308.x

Cited by 84 publications

(66 citation statements)

References 41 publications

(51 reference statements)

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“…Results showed that the 'no-go' were associated with a frontal shift of the so-called NGA 2 in the GTS, but not in the OCD group. With a comparable STOP-task, we also found results similar to Johannes et al, (Johannes, Wieringa et al, 2001a) where the NGA related to the stop/inhibition was larger over frontal areas in the GTS group even in the absence of OCD comorbidity (Thibault et al, 2009). This finding led to the hypothesis that an overactivated frontal inhibitory function is specific to GTS patients.…”

Section: Inhibitory and Sensorimotor Integration Specificity In Gtssupporting

confidence: 77%

“…Using LRPs, the team of Johannes et coll. (Johannes, Wieringa et al, 2001b) failed to show any response-specific difference to GTS patients. In this paradigm, however, stimulus-locked LRPs were pooled across conditions and the peak amplitude was analyzed as a non-specific measure of motor processing, which may have reduced its sensitivity to detect any subtle motor processing differences.…”

Section: Cognitive Electrophysiology and Experimental Neuropsychologymentioning

confidence: 99%

“…During a motor inhibition task, however, the profile was different. Inhibitory mechanisms were investigated in a go-nogo task to assess whether sensorimotor integration processes are similar in GTS and OCD (Johannes, Wieringa et al, 2001a). Results showed that the 'no-go' were associated with a frontal shift of the so-called NGA 2 in the GTS, but not in the OCD group.…”

Section: Inhibitory and Sensorimotor Integration Specificity In Gtsmentioning

confidence: 99%

See 2 more Smart Citations

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Lavoie¹,

O’Connor²

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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Section: Inhibitory and Sensorimotor Integration Specificity In Gtssupporting

confidence: 77%

Section: Cognitive Electrophysiology and Experimental Neuropsychologymentioning

confidence: 99%

Section: Inhibitory and Sensorimotor Integration Specificity In Gtsmentioning

confidence: 99%

See 1 more Smart Citation

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Lavoie¹,

O’Connor²

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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“…However, our sample size compares to earlier samples in the ERP field, which used GTS patients samples at n=6 (Van de Wetering et al, 1985), n=10 (Johannes et al, 2001a(Johannes et al, ,b, 2003, n=12 (Johannes et al, 1997) and n=24 (van Woerkom et al, 1994). The same applies with ERP studies of OCD patients with various sample sizes from a n=8 (Di Russo et al, 2000), n=9 (Gehring et al, 2000), n=13 (Morault et al, 1997), n=15 (Sanz et al, 2001) and n=21 (Morault et al, 1998).…”

Section: Possible Influences Of Confounding Variablesmentioning

confidence: 89%

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Thibault

Felezeu

O’Connor

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Approximately 30 to 50% of people suffering from Gilles de la Tourette Syndrome (GTS) also fulfill diagnostic criteria for obsessive-compulsive disorder (OCD). Despite this high degree of comorbidity, very few studies have addressed the question of obsessive-compulsive symptoms (OCS) in GTS patients using specific brain event-related potentials (ERP) responses. The aim of the current study was to quantify neurocognitive aspects of comorbidity, using ERPs. Fourteen adults with GTS (without OCD) were compared to a group of 12 participants with GTS and comorbid obsessive-compulsive symptoms (GTS+OCS), to a group of 15 participants with OCD and to a group of 14 control participants without neurological or psychiatric problems. The P200 and P300 components were recorded during a visual counting oddball task. Results showed intact P200 amplitude in all groups, whilst the P300 amplitude was affected differentially across groups. The P300 oddball effect was reduced in participants in both OCD and GTS+OCS groups in the anterior region. However, the P300 oddball effect was significantly larger in participants of the GTS group compared to all other groups, mostly in the parietal region. These findings suggest that adults with GTS are characterized by enhanced working memory updating processes and that the superimposition of OCS can lead to a reduction of these processes. The discrepancy between our findings and results obtained in previous studies on GTS could reflect the modulating effect of OCS on late ERP components.

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“…Behavioral level studies typically involve inhibition of motor responses and impulse control (e.g., Johannes et al, 2001). Cognitive level studies focus on the mental processes of attention and memory in contexts where unwanted thoughts or inappropriate meanings of ambiguous words have to be suppressed (e.g., Copland, Chenery, & Murdoch, 2000;Gernsbacher & Faust, 1991;Wegner, 1992;Wenzlaff & Wegner, 2000).…”

mentioning

confidence: 99%

Inhibition Control and Working Memory Capacity in Children With Sli

Marton

Kelmenson

Pinkhasova

2007

An International Journal of Psychological Sciences

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This study examined the "inefficient inhibition hypothesis" (IIH; Bjorklund & Harnishfeger, 1990;Wilson & Kipp, 1998) in three groups: children with specific language impairment (SLI), age-matched and language-matched controls. The IIH suggests that individuals with efficient inhibition skills perform better on working memory tasks because they are able to keep out irrelevant information from working memory. Children with SLI show processing capacity limitations. This study examined whether the working memory limitations are impacted by inhibition problems in this population. Working memory capacity was measured with a listening span task and children's inhibition errors were categorized. These errors reflected either immediate or delayed inhibition problems and they indicated either contextual distractions or perseverations. Children with SLI produced more inhibition errors than their peers in most categories. The results show an association between inhibition control and working memory capacity, but the direction of causality is not clear.

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Altered inhibition of motor responses in Tourette Syndrome and Obsessive-Compulsive Disorder

Abstract: The data are interpreted to indicate altered frontal inhibitory functions. Similarities and dissimilarities between the findings for TS and OCD are discussed with respect to other pathophysiologic aspects of the disorders.

Cited by 84 publications

References 41 publications

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Neurocognitive Aspects of Tourette Syndrome and Related Disorders

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Inhibition Control and Working Memory Capacity in Children With Sli

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