Altered Hypothalamic Functional Connectivity Following Total Sleep Deprivation in Young Adult Males

Abstract

Background: Sleep deprivation can markedly influence vigilant attention that is essential to complex cognitive processes. The hypothalamus plays a critical role in arousal and attention regulation. However, the functional involvement of the hypothalamus in attentional impairments after total sleep deprivation (TSD) remains unclear. The purpose of this study is to investigate the alterations in hypothalamic functional connectivity and its association with the attentional performance following TSD.Methods: Thirty healthy adult males were recruited in the study. Participants underwent two resting-state functional magnetic resonance imaging (rs-fMRI) scans, once in rested wakefulness (RW) and once after 36 h of TSD. Seed-based functional connectivity analysis was performed using rs-fMRI for the left and right hypothalamus. Vigilant attention was measured using a psychomotor vigilance test (PVT). Furthermore, Pearson correlation analysis was conducted to investigate the relationship between altered hypothalamic functional connectivity and PVT performance after TSD.Results: After TSD, enhanced functional connectivity was observed between the left hypothalamus and bilateral thalamus, bilateral anterior cingulate cortex, right amygdala, and right insula, while reduced functional connectivity was observed between the left hypothalamus and bilateral middle frontal gyrus (AlphaSim corrected, P < 0.01). However, significant correlation between altered hypothalamic functional connectivity and PVT performance was not observed after Bonferroni correction (P > 0.05).Conclusion: Our results suggest that TSD can lead to disrupted hypothalamic circuits, which may provide new insight into neural mechanisms of attention impairments following sleep deprivation.

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“…For instance, patients with insomnia disorder vs. healthy controls showed stronger hypothalamic rsFCs with bilateral medial frontal cortex and left pallidum and weaker rsFCs with right inferior temporal cortex ( Ding et al, 2021 ). Healthy adult males showed elevated hypothalamic rsFCs with bilateral thalamus and anterior cingulate cortex, right amygdala, and insula and reduced rsFCs with the middle frontal gyrus after 36 h of sleep deprivation, as compared to rested wakefulness ( Qi et al, 2021 ).…”