Altered HSC fate underlies aberrant blood phenotypes in rheumatoid arthritis

Pietras, Eric M.; Hernandez, Giovanny; Kuldanek, Susan; Jennifer, Rabe; Kirkpatrick, Gregory D.; Noetzli, Leila; Acharya, Sumitra; Adane, Biniam; Jordan, Craig T.; DiPaola, Jorge; Holers, Michael; Banda, Nirmal K.

doi:10.1016/j.exphem.2017.06.143

Cited by 1 publication

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“…In ulcerative colitis, the enhanced serum levels of IFN-γ in patients are highly associated with the development of clonal haematopoiesis, especially with DNMT3A and PPM1D mutations [89]. The systemic increase in IL-1 and TNF in rheumatoid arthritis promotes myeloid-biased differentiation in HSCs, along with broad suppression on diverse HSC-niche cell types [90,91] Hematologic malignancies: continuous dysregulated inflammatory stress on HSCs may contribute to the emergence of mutations and confer selective advantages to certain HSC clones, promoting clonal haematopoiesis. Functional loss of TET2, an epigenetic regulator, is a common mutation in myeloid malignancies and promotes haematopoietic transformation by elevating the self-renewal capacity of the mutated cells [92,93].…”

Section: Chronic Inflammationmentioning

confidence: 99%

Inflammation Regulates Haematopoietic Stem Cells and Their Niche

Takizawa

2022

IJMS

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Haematopoietic stem cells (HSCs) reside in the bone marrow and are supported by the specialised microenvironment, a niche to maintain HSC quiescence. To deal with haematopoietic equilibrium disrupted during inflammation, HSCs are activated from quiescence directly and indirectly to generate more mature immune cells, especially the myeloid lineage cells. In the process of proliferation and differentiation, HSCs gradually lose their self-renewal potential. The extensive inflammation might cause HSC exhaustion/senescence and malignant transformation. Here, we summarise the current understanding of how HSC functions are maintained, damaged, or exhausted during acute, prolonged, and pathological inflammatory conditions. We also highlight the inflammation-altered HSC niche and its impact on escalating the insults on HSCs.

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Section: Chronic Inflammationmentioning

confidence: 99%

Inflammation Regulates Haematopoietic Stem Cells and Their Niche

Takizawa

2022

IJMS

View full text Add to dashboard Cite

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Altered HSC fate underlies aberrant blood phenotypes in rheumatoid arthritis

Cited by 1 publication

References 0 publications

Inflammation Regulates Haematopoietic Stem Cells and Their Niche

Inflammation Regulates Haematopoietic Stem Cells and Their Niche

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