Altered homeostasis of trace elements in the blood of SCA2 patients

Trace elements profile in the blood of Huntington’ disease patients

“…Venous blood was collected in heparinized vacutainer BD tubes (Becton Dickinson Labware, Franklin Lakes, USA) and stored at −20 °C until required for analysis. The quantification of 15 trace elements was performed by using a Thermo Xseries II ICP-MS instrument (Thermo Scientific, Germany), following the protocol already described in previous studies [9,10]. Calibration curves, with Rhodium and Germanium as internal, were prepared using multi-element standard solutions dissolved in acidified ultrapure water, at concentrations from 0.25 ng mL 1 to 50 ng mL -1 .…”

Nutritional Care and Intervention in Spinocerebellar Ataxia

“…Some trace elements including zinc, copper and iron and manganese, have been associated with Neurological disorders. Some evidence also describes the link between zinc and neurological and the inverse relationship between zinc supplementation and the resolution of these symptoms [27][28][29]. Zinc has been associated with brain function and development and is also a potent antioxidant which combats the actions of prooxidants, superoxides and reactive oxygen species which negatively impact degenerative neurological disorders.…”

Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2

“…It was reported in the literature that the developing cerebellum is highly vulnerable to the damaging effects of the reacting oxygen species, and the structural changes in the PCs, their dendrites, granule cells, astrocytes, microglia, neuronal axons, and oligodendroglia are observed in the induced oxidative stress [57]. The cerebellar oxidative stress-related alterations typical for SCA2 patients can be related to the altered homeostasis of the different elements in the serum or blood samples [58,59]. Thus, it was reported that the levels of copper, manganese, zinc, and vanadium are disturbed in the blood of SCA2 patients [58].…”

“…The cerebellar oxidative stress-related alterations typical for SCA2 patients can be related to the altered homeostasis of the different elements in the serum or blood samples [58,59]. Thus, it was reported that the levels of copper, manganese, zinc, and vanadium are disturbed in the blood of SCA2 patients [58]. The reduced levels of the superoxide dismutase (SOD3) enzymatic activity were detected in SCA2 patients with no significant impact on the clinical phenotype [60].…”