Altered hippocampal information coding and network synchrony in APP-PS1 mice

Cayzac, Sebastien; Mons, Nicole; Ginguay, Antonin; Allinquant, Bernadette; Jeantet, Yannick; Cho, Yoon H.

doi:10.1016/j.neurobiolaging.2015.08.023

Cited by 44 publications

(59 citation statements)

References 68 publications

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“…The "arrhythmic stimulation" protocol introduced a random jitter in the interpulse interval duration that did not exceed 30 ms. Before applying these protocols in a closed-loop optogenetic feedback stimulation in vivo, we carried out whole-cell patch-clamp recordings of PV + and CA1 pyramidal neurons (PYR) in acute slices of wild type PV-Cre mice injected with rAAV2-Ef1a-DIO C1V1 (t/t)-TS-mCherry ( Figure 3a). These experiments Taken together, we found that the peak frequency of theta oscillations in APP/PS1 mice was significantly reduced when compared to wild type littermates (albeit their higher movement speeds), a finding which is consistent with previous reports in patients and AD mouse models [12][13][14] . Most remarkably, the closed-loop rhythmic optogenetic stimulation of hippocampal PV + interneurons effectively rescued the impaired recognition memory of APP/PS1 mice during the novel object recognition task bringing it back to levels comparable to wild type mice.…”

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confidence: 93%

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Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model

Poll

Justus

et al. 2018

Preprint

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Disrupted neural oscillations are a feature of Alzheimer’s disease (AD). We observed reduced frequency of theta oscillations in the hippocampal local field potential (LFP) in a mouse model of beta-amyloidosis. By restoring the temporal organization of theta oscillations using LFP-guided closed-loop optogenetic stimulation of parvalbumin-positive interneurons, we could rescue memory deficits of APP/PS1 mice in the novel object recognition test.

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confidence: 93%

“…They are driven by rhythmic activity of septo-hippocampal projections, which target hippocampal interneurons 9 . A reduced theta frequency has been observed in AD mouse models and patients [12][13][14] . Notably, we and others have previously shown that AD-like pathology results in inhibitory interneuron dysfunction 15 .…”

mentioning

confidence: 99%

Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model

Poll

Justus

et al. 2018

Preprint

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“…Cayzac et al [70] described alterations in local oscillatory activity in the theta range; however these findings were obtained under restrained tether recording conditions using mixed, unbalanced gender distribution in the study groups which is critical for interpretation.…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease

et al. 2016

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Alzheimer's disease (AD) is a multifactorial disorder leading to progressive memory loss and eventually death. In this study an APPswePS1dE9 AD mouse model has been analyzed using implantable video-EEG radiotelemetry to perform long-term EEG recordings from the primary motor cortex M1 and the hippocampal CA1 region in both genders. Besides motor activity, EEG recordings were analyzed for electroencephalographic seizure activity and frequency characteristics using a Fast Fourier Transformation (FFT) based approach. Automatic seizure detection revealed severe electroencephalographic seizure activity in both M1 and CA1 deflection in APPswePS1dE9 mice with gender-specific characteristics. Frequency analysis of both surface and deep EEG recordings elicited complex age, gender, and activity dependent alterations in the theta and gamma range. Females displayed an antithetic decrease in theta (θ) and increase in gamma (γ) power at 18-19 weeks of age whereas related changes in males occurred earlier at 14 weeks of age. In females, theta (θ) and gamma (γ) power alterations predominated in the inactive state suggesting a reduction in atropine-sensitive type II theta in APPswePS1dE9 animals. Gender-specific central dysrhythmia and network alterations in APPswePS1dE9 point to a functional role in behavioral and cognitive deficits and might serve as early biomarkers for AD in the future.

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“…Place cell abnormalities have been reported in several mouse models of AD (Cacucci et al, 2008;Cheng and Ji, 2013;Zhao et al, 2014;Cayzac et al, 2015;Booth et al, 2016). Moreover, disturbed theta and gamma oscillations in the hippocampus have been observed in transgenic and Ab injection models of AD (Villette et al, 2010;Rubio et al, 2012;Cheng and Ji, 2013;Ittner et al, 2014;Schneider et al, 2014;Cayzac et al, 2015;Ciupek et al, 2015;Gillespie et al, 2016;Iaccarino et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease

et al. 2017

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Alzheimer's disease (AD) is an irreversible and highly progressive neurodegenerative disease. Clinically, patients with AD display impairments in episodic and spatial memory. However, the underlying neuronal dysfunctions that result in these impairments remain poorly understood. The hippocampus is crucial for spatial and episodic memory, and thus we tested the hypothesis that abnormal neuronal representations of space in the hippocampus contribute to memory deficits in AD. To test this hypothesis, we recorded spikes from place cells in hippocampal subfield CA1, together with corresponding rhythmic activity in local field potentials, in the 3xTg AD mouse model. We observed disturbances in place cell firing patterns, many of which were consistent with place cell disturbances reported in other rodent models of AD. We found place cell representations of space to be unstable in 3xTg mice compared to control mice. Furthermore, coordination of place cell firing by hippocampal rhythms was disrupted in 3xTg mice. Specifically, a smaller proportion of place cells from 3xTg mice were significantly phase-locked to theta and slow gamma rhythms, and the theta and slow gamma phases at which spikes occurred were also altered. Remarkably, these disturbances were observed at an age before detectable Aβ pathology had developed. Consistencies between these findings in 3xTg mice and previous findings from other AD models suggest that disturbances in place cell firing and hippocampal rhythms are related to AD rather than reflecting peculiarities inherent to a particular transgenic model. Thus, disturbed rhythmic organization of place cell activity may contribute to unstable spatial representations, and related spatial memory deficits, in AD. © 2017 Wiley Periodicals, Inc.

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Altered hippocampal information coding and network synchrony in APP-PS1 mice

Cited by 44 publications

References 68 publications

Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model

Restoring memory by optogenetic synchronization of hippocampal oscillations in an Alzheimer’s disease mouse model

Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer’s Disease

Impairments in spatial representations and rhythmic coordination of place cells in the 3xTg mouse model of Alzheimer's disease

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