Altered hemispheric lateralization of white matter pathways in developmental dyslexia: Evidence from spherical deconvolution tractography

Zhao, Jingjing; Schotten, Michel Thiebaut de; Altarelli, Irène; Dubois, Jessica; Ramus, Franck

doi:10.1016/j.cortex.2015.12.004

Cited by 80 publications

(112 citation statements)

References 76 publications

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“…Fiber tracking revealed that some of the fibers in the bigger cluster belonged to the AF. Consistently, tractography studies confirmed such evidence showing reduced FA in the left AF in children with dyslexia (Christodoulou et al, ; Zhao, Thiebaut de Schotten, Altarelli, Dubois, & Ramus, ). Other studies, however, report lower FA and axial diffusivity (AD) in individuals with dyslexia compared with typical readers in widespread ventral and dorsal clusters, mostly in the left but also in the right hemisphere (Moura et al, ; Richards et al, , ).…”

Section: Introductionsupporting

confidence: 55%

“…Structural asymmetries in the white matter were reported as well. The AF was shown to be left‐lateralized in adults and children (Catani et al, ; Lebel & Beaulieu, ; Qiu, Tan, Siok, Zhou, & Khong, ; Vandermosten, Poelmans, Sunaert, Ghesquière, & Wouters, ; Yeatman et al, ; Zhao et al, ). Its left‐lateralization was positively correlated with language‐related skills such as word learning (Catani et al, ), receptive vocabulary, phonological processing (Lebel & Beaulieu, ), and was associated with better reading scores (Qiu et al, ; but see Yeatman et al, for a negative correlation with reading).…”

Section: Introductionmentioning

confidence: 99%

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White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits

Banfi

Koschutnig

Moll

et al. 2018

Human Brain Mapping

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The present study investigated whether children with a typical dyslexia profile and children with isolated spelling deficits show a distinct pattern of white matter alteration compared with typically developing peers. Relevant studies on the topic are scarce, rely on small samples, and often suffer from the limitations of conventional tensor‐based methods. The present Constrained Spherical Deconvolution study includes 27 children with typical reading and spelling skills, 21 children with dyslexia and 21 children with isolated spelling deficits. Group differences along major white matter tracts were quantified utilizing the Automated Fiber Quantification software and a lateralization index was calculated in order to investigate the structural asymmetry of the tracts. The two deficit groups mostly displayed different patterns of white matter alterations, located in the bilateral inferior longitudinal fasciculi, right superior longitudinal fasciculus, and cingulum for the group with dyslexia and in the left arcuate fasciculus for the group with isolated spelling deficits. The two deficit groups differed also with respect to structural asymmetry. Children with dyslexia did not show the typical leftward asymmetry of the arcuate fasciculus, whereas the group with isolated spelling deficits showed absent rightward asymmetry of the inferior fronto‐occipital fasciculus. This study adds evidence to the notion that different profiles of combined or isolated reading and spelling deficits are associated with different neural signatures.

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Section: Introductionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits

Banfi

Koschutnig

Moll

et al. 2018

Human Brain Mapping

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show abstract

“…For instance, visuo‐spatial neglect, a severe neurological condition characterized by the loss of half of the visual field's awareness, is associated with the disruption of the fibres connecting the frontal to the parietal lobe . Tractography also contributed to the establishment or confirmation of a new disconnection hypothesis for Gerstmann syndrome, and neurodevelopmental hypoconnectivity hypotheses for psychopathy, dyslexia and congenital prosopagnosia . Conversely, aberrant/increased connections (i.e.…”

Section: Functional Modelsmentioning

confidence: 99%

The role of diffusion MRI in neuroscience

2017

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Diffusion‐weighted imaging has pushed the boundaries of neuroscience by allowing us to examine the white matter microstructure of the living human brain. By doing so, it has provided answers to fundamental neuroscientific questions, launching a new field of research that had been largely inaccessible. We briefly summarize key questions that have historically been raised in neuroscience concerning the brain's white matter. We then expand on the benefits of diffusion‐weighted imaging and its contribution to the fields of brain anatomy, functional models and plasticity. In doing so, this review highlights the invaluable contribution of diffusion‐weighted imaging in neuroscience, presents its limitations and proposes new challenges for future generations who may wish to exploit this powerful technology to gain novel insights.

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“…The efficient integration across these spatially disparate brain regions is made possible by long‐range white matter connections that form across development (Wandell, Rauschecker, & Yeatman, ). Three white matter tracts in particular have a documented association with reading and reading‐related skills in adults and children as early as preschool (1) arcuate fasciculus (AF), connecting the superior temporal lobe with the inferior frontal gyrus (IFG); (2) superior longitudinal fasciculus (SLF), connecting the inferior parietal with the inferior frontal/premotor regions; and (3) inferior longitudinal fasciculus (ILF), connecting the posterior inferior temporal gyrus with the ventral anterior and medial temporal lobe (Deutsch et al, ; Frye et al, ; Klingberg et al, ; Lebel & Beaulieu, ; Myers et al, ; Niogi & McCandliss, ; Travis, Adams, Kovachy, Ben‐Shachar, & Feldman, ; Yeatman, Dougherty, Ben‐Shachar, & Wandell, ; Yeatman et al, ; Saygin et al, ; Vandermosten, Boets, Wouters, & Ghesquiere, ; Wang et al, ; Zhao, de Schotten, Altarelli, Dubois, & Ramus, ; Supporting Information Figure S1). The left ILF passes in close proximity to the visual word form area (Yeatman, Rauschecker, & Wandell, ), a cortical region that becomes left‐lateralized and specialized for word recognition through experience (Cohen et al, ; Dehaene & Cohen, ).…”

Section: Introductionmentioning

confidence: 99%

The relationship between socioeconomic status and white matter microstructure in pre‐reading children: A longitudinal investigation

Ozernov‐Palchik

Norton

Wang

et al. 2018

Human Brain Mapping

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Reading is a learned skill crucial for educational attainment. Children from families of lower socioeconomic status (SES) tend to have poorer reading performance and this gap widens across years of schooling. Reading relies on the orchestration of multiple neural systems integrated via specific white-matter pathways, but there is limited understanding about whether these pathways relate differentially to reading performance depending on SES background. Kindergarten white-matter FA and second-grade reading outcomes were investigated in an SES-diverse sample of 125 children. The three left-hemisphere white-matter tracts most associated with reading, and their right-hemisphere homologs, were examined: arcuate fasciculus (AF), superior longitudinal fasciculus (SLF), and inferior longitudinal fasciculus (ILF). There was a significant and positive association between SES and fractional anisotropy (FA) in the bilateral ILF in kindergarten. SES moderated the association between kindergarten ILF and second grade reading performance, such that it was positive in lower-SES children, but not significant in higher-SES children. These results have implications for understanding the role of the environment in the development of the neural pathways that support reading.

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Altered hemispheric lateralization of white matter pathways in developmental dyslexia: Evidence from spherical deconvolution tractography

Cited by 80 publications

References 76 publications

White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits

White matter alterations and tract lateralization in children with dyslexia and isolated spelling deficits

The role of diffusion MRI in neuroscience

The relationship between socioeconomic status and white matter microstructure in pre‐reading children: A longitudinal investigation

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