Altered hemispheric asymmetry of auditory magnetic fields to tones and syllables in schizophrenia

Rockstroh, Brigitte; Kißler, Johanna; Mohr, Bettina; Eulitz, Carsten; Lommen, Ursula; Wienbruch, Christian; Cohen, Rudolf; Elbert, Thomas

doi:10.1016/s0006-3223(00)01023-4

Cited by 42 publications

(33 citation statements)

References 38 publications

(40 reference statements)

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“…This basic observation has been confirmed for right-handed male subjects by several other investigators (Reite et al, 1989;Makela et al, 1993;Eulitz, Diesch, Pantev, Hampson, & Elbert, 1995;Tiihonen et al, 1998;Ohtomo et al, 1998;Edgar et al, 1997;Rockstroh et al, 2001). Reite and colleagues further reported that right-handed male patients with schizophrenia fail to show the expected pattern of right-left asymmetry for the location of the M100 dipole source as evaluated using MEG Rojas et al, 1997;Teale et al, 2000), and others have provided independent supporting data (Tiihonen et al 1998;Edgar et al, 1997;Rockstroh et al, 2001). …”

Section: Asymmetry In the Source Localizationsupporting

confidence: 59%

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Roberts

Schmidt

Egeth

et al. 2008

International Journal of Psychophysiology

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While magnetoencephalography (MEG) is of increasing utility in the assessment of pediatric patients with seizure disorders, this indication reflects only a part of the clinical potential of the technology. Beyond epilepsy, a broad range of developmental psychiatric disorders require the combined offerings of spatial and temporal resolution, along with direct sensitivity to neural electrical activity, that are offered by MEG. This article reviews the application of MEG in the study of auditory processing as an aspect of language impairment in children. Potential application is elaborated in the clinical case of autism spectrum disorders, a devastating disorder with prevalence of 1 in 150, poorly served by alternative imaging modalities. MEG offers both spatial and temporal insights, tentatively described as "electrophysiological signatures". Results demonstrate the sensitivity of MEG for detection of abnormalities of auditory processing in ASD and their clinical correlates. These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders such as autism, but also suggest avenues for the development of MEG technology to adequately meet the needs of such populations, as well as providing conduits to basic sciences including neurobiology and genetics.

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Section: Asymmetry In the Source Localizationsupporting

confidence: 59%

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Roberts

Schmidt

Egeth

et al. 2008

International Journal of Psychophysiology

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Section: Introductionmentioning

confidence: 85%

“…In normal adults, the neuroanatomical source of the M100 component is further anterior in the right hemisphere (Baumann et al, 1991). We and others have previously shown that patients with schizophrenia demonstrate disturbed inter-hemispheric asymmetry of the M100 generator location , Reite et al, 1989, Rockstroh et al, 2001, Tiihonen et al, 1998.The M100 component appears to be generated by lateral aspects of the transverse gyrus of Heschl and the planum temporale of the superior temporal gyrus (Godey et al, 2001, Reite et al, 1994. Abnormal planum temporale asymmetry has also been implicated as disturbed in schizophrenia (e.g., Shapleske et al, 1999 for a review).…”

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confidence: 93%

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

Rojas

Slason

Teale

et al. 2007

Schizophrenia Research

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Deficits in basic auditory perception have been described in schizophrenia. Previous electrophysiological imaging research has documented a structure-function disassociation in the auditory system and altered tonotopic mapping in schizophrenia. The present study examined auditory cortical tuning in patients with schizophrenia.Eighteen patients with schizophrenia and 15 comparison subjects were recorded in a magnetoencephalographic (MEG) experiment of auditory tuning. Auditory cortical tuning at 1 kHz was examined by delivering 1 kHz pure tones in conjunction with pure tones at 5 frequencies surrounding and including 1 kHz. Source reconstruction data were examined for evidence of frequency specificity for the M100 component.There was a significant broadening of tuning in the schizophrenia group evident for the source amplitude of the M100. The frequently reported reduction in anterior-posterior source asymmetry for individuals with schizophrenia was replicated in this experiment. No relationships between symptom severity ratings and MEG measures were observed.This finding suggests that the frequency specificity of the M100 auditory evoked field is disturbed in schizophrenia, and may help explain the relatively poor behavioral performance of schizophrenia patients on simple frequency discrimination tasks. KeywordsMagnetoencephalography; Evoked Potentials; Auditory Cortex; Mental Illness; N100; M100 Corresponding Author: Donald C. Rojas, Ph.D. Box C268−68 CPH Rm 2J10 4200 E. 9th Avenue Denver, CO 80262 Phone: (303) 315 −8624 FAX: (303) 315−5641 email: Don.Rojas@uchsc.edu. Contributors D.C.R designed the study, performed the statistical analysis and wrote the manuscript. E.S. contributed data analyses and preliminary statistical analyses. P.D.T. contributed to the design of the experiment and selection of data analytic strategies and M.L.R. had substantial input on clinical aspects of the design, including selection and implementation of schizophrenia diagnostic and clinical measures appearing in the paper. All authors have contributed to and approved the final manuscript.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of InterestAll authors declare that they have no conflicts of interest with respect to this manuscript. NIH Public Access IntroductionThe M100 auditory evoked field has been reported to show anomalous anterior-posteior source location asymmetry in actively psychotic patients with paranoid schizophrenia. In normal adults, the neuroanatomical source of the M100 component is further anterior in the right hemisphere (Baumann et al., 1991). We and ...

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“…Of note, an alteration that deviates from normal asymmetry has been explored in schizophrenia (Holinger et al, 2000) in neuroanatomy, including both postmortem studies of parahippocampal, fusiform gyri, and temporal lobe (Highley et al, 1998a(Highley et al, ,b, 1999McDonald et al, 2000), and in MRI studies of temporal lobe, anterior cingulate gyrus, and frontal lobe (Takahashi et al, 2002;Turetsky et al, 1995), as well as in functions, including auditory processing such as mismatch negativity Rockstroh et al, 2001;Sommer et al, 2001;Youn et al, 2003). Alterations in white matter asymmetry in schizophrenia have also been exploited using DT-MRI, in studies looking at the cingulum bundle and uncinate fasciculus (Kubicki et al, 2002Zhou et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

et al. 2004

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Hemisphere asymmetry was explored in normal healthy subjects and in patients with schizophrenia using a novel voxel-based tensor analysis applied to fractional anisotropy (FA) of the diffusion tensor. Our voxel-based approach, which requires precise spatial normalization to remove the misalignment of fiber tracts, includes generating a symmetrical group average template of the diffusion tensor by applying nonlinear elastic warping of the demons algorithm. We then normalized all 32 diffusion tensor MRIs from healthy subjects and 23 from schizophrenic subjects to the symmetrical average template. For each brain, six channels of tensor component images and one T2-weighted image were used for registration to match tensor orientation and shape between images. A statistical evaluation of white matter asymmetry was then conducted on the normalized FA images and their flipped images. In controls, we found left-higher-than-right anisotropic asymmetry in the anterior part of the corpus callosum, cingulum bundle, the optic radiation, and the superior cerebellar peduncle, and right-higher-than-left anisotropic asymmetry in the anterior limb of the internal capsule and the anterior limb's prefrontal regions, in the uncinate fasciculus, and in the superior longitudinal fasciculus. In patients, the asymmetry was lower, although still present, in the cingulum bundle and the anterior corpus callosum, and not found in the anterior limb of the internal capsule, the uncinate fasciculus, and the superior cerebellar peduncle compared to healthy subjects. These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neuro-developmental abnormalities in schizophrenia.

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Altered hemispheric asymmetry of auditory magnetic fields to tones and syllables in schizophrenia

Cited by 42 publications

References 38 publications

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia

White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

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