Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity

Youn, Tae Jin; Park, Hae Jeong; Kim, Jae Jin; Kim, Myung Sun; Kwon, Jun Soo

doi:10.1016/s0920-9964(02)00154-8

Cited by 96 publications

(66 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whereas this finding has been reported previously, it has been observed only in samples with chronic schizophrenia. 40,41 It is important to note, however, that it is likely that impairments at mastoid/ temporal sites have often not been reported owing to limitations in recording techniques (e.g., the mastoids or linked ears were used as the reference, thus precluding a viable analysis of ERPs at or near the mastoid sites). 7,42,43 Contrary to previous understanding, our finding suggests that there is a disruption of temporal neural networks in the early stages of schizophrenia-spectrum psychoses in addition to the commonly reported frontocentral impairment.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster

Kaur

Battisti

Lagopoulos

et al. 2012

J Psychiatry Neurosci

View full text Add to dashboard Cite

IntroductionA current topic of controversy in psychiatry is whether or not bipolar-spectrum disorders should be considered as part of the psychosis cluster in the upcoming DSM-V. Currently, bipolarspectrum disorders are classified as mood disorders in line with the Kraeplinian dichotomy; however, recent literature suggests that there may be more overlap in the underlying neurobiology in these major psychiatric illnesses than once thought.1 It is not unusual for patients with similar pheno typic presentation and common symptomatology to receive a diagnosis of either a bipolar-spectrum or a schizophrenia-spectrum disorder, particularly in the early stages of illness. Thus, investigation of the underlying neurobiology of these 2 major psychi atric groups is crucial to our understanding of their pathophysiological overlap. Shared genetic vulnerabilities in individuals with bipolar disorder and schizophrenia have been documented and describe how some symptoms overlap and how some are unique. [2][3][4][5] In support of the shared genetic basis of these disorders, there is evidence that first-degree relatives of probands with bipolar disorder or schizophrenia are at increased risk for either disorder, irrespective of the phenotype present in their relative. Background: Mismatch negativity (MMN) and P3a are event-related potentials that index deviance detection and the orienting response, respectively. We have previously shown that the MMN/P3a complex is impaired in patients with schizophrenia and affective spectrum psychoses, which suggests that it may index a common pathophysiology and argues against the purported specificity in schizo phrenia. Further research is warranted to determine whether patients with bipolar-spectrum disorders show similar impairments in these biomarkers. Methods: We assessed patients aged 15-30 years with early schizophrenia-spectrum disorders (schizophrenia, schizoaffective disorder, schizophreniform disorder), early bipolar-spectrum disorders (bipolar I or II, with and without psychotic features) and healthy, matched controls. We acquired MMN/P3a amplitudes during a 2-tone, auditory paradigm with 8% duration deviants. Clinical, psychosocial and neuro psychological assessments were also undertaken. Results: We included 20 patients with schizophrenia-spectrum disorders, 20 with bipolar-spectrum disorders and 20 controls in our study. Both patient groups showed significantly reduced frontocentral MMN and central P3a amplitudes. The schizophrenia-spectrum group had additional impairments in left temporal MMN and frontal P3a. Both patient groups performed worse than controls across psychosocial and clinical measures; however, only the schizophrenia-spectrum group performed significantly worse than controls for cognitive measures. Correlational analyses between patient groups revealed associations between frontocentral or left temporal MMN and psychiatric symptomatology or quality of life measures. Limitations: Limitations to our study include the modest sample size and the lack of control with r...

show abstract

Section: Discussionmentioning

confidence: 99%

Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster

Kaur

Battisti

Lagopoulos

et al. 2012

J Psychiatry Neurosci

View full text Add to dashboard Cite

show abstract

“…Mean MMN amplitudes as compared for the two groups (Thick line = PTSD group, thin line = control group). Kamio et al, 2001;Kujala and Näätänen 2001;Pekkonen et al, 2002;Salisbury et al, 2002;Bar-Haim et al, 2003;Umbricht et al, 2003;Youn et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Reduced mismatch negativity in posttraumatic stress disorder: A compensatory mechanism for chronic hyperarousal?

Menning

Renz

Seifert

et al. 2008

International Journal of Psychophysiology

View full text Add to dashboard Cite

“…Of note, an alteration that deviates from normal asymmetry has been explored in schizophrenia (Holinger et al, 2000) in neuroanatomy, including both postmortem studies of parahippocampal, fusiform gyri, and temporal lobe (Highley et al, 1998a(Highley et al, ,b, 1999McDonald et al, 2000), and in MRI studies of temporal lobe, anterior cingulate gyrus, and frontal lobe (Takahashi et al, 2002;Turetsky et al, 1995), as well as in functions, including auditory processing such as mismatch negativity Rockstroh et al, 2001;Sommer et al, 2001;Youn et al, 2003). Alterations in white matter asymmetry in schizophrenia have also been exploited using DT-MRI, in studies looking at the cingulum bundle and uncinate fasciculus (Kubicki et al, 2002Zhou et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

et al. 2004

Self Cite

View full text Add to dashboard Cite

Hemisphere asymmetry was explored in normal healthy subjects and in patients with schizophrenia using a novel voxel-based tensor analysis applied to fractional anisotropy (FA) of the diffusion tensor. Our voxel-based approach, which requires precise spatial normalization to remove the misalignment of fiber tracts, includes generating a symmetrical group average template of the diffusion tensor by applying nonlinear elastic warping of the demons algorithm. We then normalized all 32 diffusion tensor MRIs from healthy subjects and 23 from schizophrenic subjects to the symmetrical average template. For each brain, six channels of tensor component images and one T2-weighted image were used for registration to match tensor orientation and shape between images. A statistical evaluation of white matter asymmetry was then conducted on the normalized FA images and their flipped images. In controls, we found left-higher-than-right anisotropic asymmetry in the anterior part of the corpus callosum, cingulum bundle, the optic radiation, and the superior cerebellar peduncle, and right-higher-than-left anisotropic asymmetry in the anterior limb of the internal capsule and the anterior limb's prefrontal regions, in the uncinate fasciculus, and in the superior longitudinal fasciculus. In patients, the asymmetry was lower, although still present, in the cingulum bundle and the anterior corpus callosum, and not found in the anterior limb of the internal capsule, the uncinate fasciculus, and the superior cerebellar peduncle compared to healthy subjects. These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neuro-developmental abnormalities in schizophrenia.

show abstract

Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity

Cited by 96 publications

References 38 publications

Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster

Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster

Reduced mismatch negativity in posttraumatic stress disorder: A compensatory mechanism for chronic hyperarousal?

White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

Contact Info

Product

Resources

About