Altered gut microbiota in patients with idiopathic Parkinson’s disease: an age–sex matched case–control study

Yildiz, Gulsen Babacan; Kayacan, Zeynep Çiğdem; Karacan, Ilker; Sümbül, Bilge; Elibol, Birsen; Gelişin, Özlem; Akgül, Özer

doi:10.1007/s13760-023-02195-0

Cited by 5 publications

(4 citation statements)

References 50 publications

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“…And, in contrast, low levels of Ruminiclostridium V have been reported for people with kidney stones [65] and rats with acute necrotizing pancreatitis [66]. Consistent with our data, the genera Ruminococcus gauvreauii group is increased by fructoooligosaccharides [26], and this genus is lower in individuals with obesity [67], coronary artery disease [68] and Parkinson's disease [69]. These findings taken together, therefore, suggest that the genera Incertae_Sedis (formerly known as Ruminiclostridium V based on ASV) and Ruminococcus gauvreauii group may be health-promoting.…”

Section: Discussionsupporting

confidence: 89%

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose <span aria-describedby="tippy-24">Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats

Thompson,

Bowers,

Vargas

et al. 2024

Preprint

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Despite substantial evidence supporting the efficacy of prebiotics for promoting host health and stress resilience, few experiments present evidence documenting the dynamic changes in microbial ecology and fecal microbial-modified metabolites across time. Furthermore, the literature reports a lack of reproducible effects of prebiotics on specific bacteria and bacterial-modified metabolites. The current experiments examined whether consumption of diets enriched in prebiotics (galactooligosaccharides, GOS and polydextrose, PDX) compared to control diet, would consistently impact the gut microbiome and microbial-modified bile acids across time and between two research sites. Male Sprague Dawley rats were fed control or prebiotic diets for several weeks, and their gut microbiome and metabolome were examined using 16S rRNA gene sequencing and untargeted LC-MS/MS analysis. Dietary prebiotics altered beta diversity, relative abundances of bacterial genera, and microbially modified bile acids across time. PICRUSt2 analyses identified four inferred functional metabolic pathways modified by prebiotic diet. Correlational network analyses between inferred metabolic pathways and microbial-modified bile acids revealed deoxycholic acid as a potential network hub. All these reported effects were consistent between the two research sites supporting the conclusion that dietary prebiotics robustly changed the gut microbial ecosystem. Consistent with our previous work demonstrating that GOS/PDX reduces the negative impacts of stressor exposure, we propose that ingesting a diet enriched in prebiotics facilitates the development of a health-promoting gut microbial ecosystem.

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Section: Discussionsupporting

confidence: 89%

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose <span aria-describedby="tippy-24">Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats

Thompson,

Bowers,

Vargas

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…And, in contrast, low levels of Ruminiclostridium V have been reported for people with kidney stones [ 53 ] and rats with acute necrotizing pancreatitis [ 54 ]. Consistent with our data, the genera Ruminococcus gauvreauii group is increased by fructooligosaccharides [ 24 ], and this genus is lower in individuals with obesity [ 55 ], coronary artery disease [ 56 ] and Parkinson’s disease [ 57 ]. These findings taken together, therefore, suggest that the genera Incertae_Sedis (formerly known as Ruminiclostridium V based on ASV) and Ruminococcus gauvreauii group may be health promoting.…”

Section: Discussionsupporting

confidence: 87%

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats

Thompson,

Bowers,

Vargas

et al. 2024

Nutrients

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Despite substantial evidence supporting the efficacy of prebiotics for promoting host health and stress resilience, few experiments present evidence documenting the dynamic changes in microbial ecology and fecal microbially modified metabolites over time. Furthermore, the literature reports a lack of reproducible effects of prebiotics on specific bacteria and bacterial-modified metabolites. The current experiments examined whether consumption of diets enriched in prebiotics (galactooligosaccharides (GOS) and polydextrose (PDX)), compared to a control diet, would consistently impact the gut microbiome and microbially modified bile acids over time and between two research sites. Male Sprague Dawley rats were fed control or prebiotic diets for several weeks, and their gut microbiomes and metabolomes were examined using 16S rRNA gene sequencing and untargeted LC–MS/MS analysis. Dietary prebiotics altered the beta diversity, relative abundance of bacterial genera, and microbially modified bile acids over time. PICRUSt2 analyses identified four inferred functional metabolic pathways modified by the prebiotic diet. Correlational network analyses between inferred metabolic pathways and microbially modified bile acids revealed deoxycholic acid as a potential network hub. All these reported effects were consistent between the two research sites, supporting the conclusion that dietary prebiotics robustly changed the gut microbial ecosystem. Consistent with our previous work demonstrating that GOS/PDX reduces the negative impacts of stressor exposure, we propose that ingesting a diet enriched in prebiotics facilitates the development of a health-promoting gut microbial ecosystem.

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“…In mice, the phyla Actinobacteria and Tenericutes were more abundant in males, while the family Lachnospiraceae was more abundant in females [4]. In addition, previous studies have shown that sex differences are associated with several diseases, including colorectal cancer [5], Parkison's disease [6], essential hypertension [7], and ischemic stroke [8].…”

Section: Introductionmentioning

confidence: 99%

A Mix of Potentially Probiotic Limosilactobacillus fermentum Strains Alters the Gut Microbiota in a Dose- and Sex-Dependent Manner in Wistar Rats

Carneiro dos Santos,

Carvalho,

Cruz Neto

et al. 2024

Microorganisms

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Multi-strain Limosilactobacillus (L.) fermentum is a potential probiotic with reported immunomodulatory properties. This study aimed to evaluate the composition, richness, and diversity of the gut microbiota in male and female rats after treatment with a multi-strain of L. fermentum at different doses. Thirty rats (fifteen male and fifteen female) were allocated into a control group (CTL), a group receiving L. fermentum at a dose of 108 CFU (Lf-108), and a group receiving L. fermentum at a dose of 1010 CFU (Lf-1010) for 13 weeks. Gut microbiota and serum cytokine levels were evaluated after L. fermentum treatment. Male CTL rats had a lower relative abundance of Bifidobacteriaceae and Prevotella and a lower alpha diversity than their female CTL counterparts (p < 0.05). In addition, male CTL rats had a higher Firmicutes/Bacteroidetes (F/B) ratio than female CTL rats (p < 0.05). In female rats, the administration of L. fermentum at 108 CFU decreased the relative abundance of Bifidobacteriaceae and Anaerobiospirillum and increased Lactobacillus (p < 0.05). In male rats, the administration of L. fermentum at 1010 CFU decreased the F/B ratio and increased Lachnospiraceae and the diversity of the gut microbiota (p < 0.05). The relative abundance of Lachnospiraceae and the alpha-diversity of gut microbiota were negatively correlated with serum levels of IL1β (r = −0.44) and TNFα (r = −0.39), respectively. This study identified important changes in gut microbiota between male and female rats and showed that a lower dose of L. fermentum may have more beneficial effects on gut microbiota in females, while a higher dose may result in more beneficial effects on gut microbiota in male rats.

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Altered gut microbiota in patients with idiopathic Parkinson’s disease: an age–sex matched case–control study

Cited by 5 publications

References 50 publications

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose <span aria-describedby="tippy-24">Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose <span aria-describedby="tippy-24">Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats

A Prebiotic Diet Containing Galactooligosaccharides and Polydextrose Produces Dynamic and Reproducible Changes in the Gut Microbial Ecosystem in Male Rats

A Mix of Potentially Probiotic Limosilactobacillus fermentum Strains Alters the Gut Microbiota in a Dose- and Sex-Dependent Manner in Wistar Rats

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