Altered Gut Microbiota in Children With Hyperuricemia

Yuan, Xin; Chen, Ruimin; Zhang, Ying; Lin, Xiaoqin; Yang, Xiaohong

doi:10.3389/fendo.2022.848715

Cited by 13 publications

(5 citation statements)

References 55 publications

(63 reference statements)

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“…A cohort study conducted previously found that gout patients had lower levels of the genus Faecalibacterium compared to healthy individuals [40]. Additionally, a case-control study in children showed a negative association between SUA levels and Faecalibacterium abundance [41]. SUA levels are a risk factor for the increased abundance of genus Prevotella9 [42].…”

Section: Discussionmentioning

confidence: 96%

Causal Relationship between Gut Microbiota and Gout: A Two-Sample Mendelian Randomization Study

Wang,

Fan,

Huang

et al. 2023

Nutrients

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Gout is a form of prevalent and painful inflammatory arthritis characterized by elevated serum urate (SUA) levels. The gut microbiota (GM) is believed to influence the development of gout and SUA levels. Our study aimed to explore the causal relationship between GM composition and gout, as well as SUA levels, utilizing a two-sample Mendelian Randomization (MR) approach. A total of 196 GM taxa from five levels were available for analysis. We identified five taxa associated with SUA levels and 10 taxa associated with gout. In reverse MR analysis, we discovered that gout affected the composition of five GM taxa, while SUA levels influenced the composition of 30 GM taxa. Combining existing research, our study unveiled a potential negative feedback loop between phylum Actinobacteria and SUA levels, establishing connections with gout. We also proposed two novel associations connecting GM taxa (genus Faecalibacterium and genus Prevotella9), SUA levels, and gout. These findings provide compelling evidence of causal relationships between specific GM taxa with SUA levels and gout, contributing valuable insights for the treatment of gout.

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Section: Discussionmentioning

confidence: 96%

Causal Relationship between Gut Microbiota and Gout: A Two-Sample Mendelian Randomization Study

Wang,

Fan,

Huang

et al. 2023

Nutrients

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“…Similarly, individuals with hyperuricemia have been found to have decreased microbial diversity and an altered gut microbiota composition compared to those with normouricemia ( 17 ). In children with hyperuricemia, serum uric acid level was positively correlated with genera Actinomyces , Morganella , and Streptococcus , and negatively associated with the short-chain fatty acids-producing bacteria, such as Alistipes , Faecalibacterium, and Oscillospira , and sulfur-producing bacteria Bilophila ( 20 ). Previous studies have shown an association between SUA, gut microbiota, and obesity.…”

Section: Introductionmentioning

confidence: 99%

The association between BMI and serum uric acid is partially mediated by gut microbiota

Duan,

Fu,

Zhang

et al. 2023

Microbiol Spectr

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Obesity is a risk factor for the development of hyperuricemia, both of which were related to gut microbiota. However, whether alterations in the gut microbiota lie in the pathways mediating obesity’s effects on hyperuricemia is less clear. Body mass index (BMI) and serum uric acid (SUA) were separately important indicators of obesity and hyperuricemia. Our study aims to investigate whether BMI-related gut microbiota characteristics would mediate the association between BMI and SUA levels. A total of 6,280 participants from Guangdong Gut Microbiome Project were included in this study. Stool samples were collected for 16S rRNA gene sequencing. The results revealed that BMI was significantly and positively associated with SUA. Meanwhile, BMI was significantly associated with the abundance of 102 gut microbial genera, 16 of which were also significantly associated with SUA. The mediation analysis revealed that the association between BMI and SUA was partially mediated by the abundance of Proteobacteria (proportion mediated: 0.94%, P < 0.05). At the genus level, 25 bacterial genera, including Ralstonia, Oscillospira, Faecalibacterium , etc., could also partially mediate the association of BMI with SUA (the highest proportion is mediated by Ralstonia , proportion mediated: 2.76%, P < 0.05). This study provided evidence for the associations among BMI, gut microbiota, and SUA, and the mediation analysis suggested that the association of BMI with SUA was partially mediated by the gut microbiota. IMPORTANCE Using 16S rRNA sequencing analysis, local interpretable machine learning technique analysis and mediation analysis were used to explore the association between BMI with SUA, and the mediating effects of gut microbial dysbiosis in the association were investigated.

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“…There have also been studies that have shown that propionic acid and butyric acid [ 44 ] are among the SCFAs that provide ATP to the cells of the intestinal wall, which excretes uric acid [ 45 ]. Acetic acid sodium and butyrate sodium reduce SUA levels in mice, and butyric acid helps maintain intestinal barrier integrity [ 46 ]. Some of the acetic and butyric acids produced in the intestine can enter the body through the bloodstream and be involved in uric acid synthesis and inhibition of XOD activity [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Postbiotic of Pediococcus acidilactici GQ01, a Novel Probiotic Strain Isolated from Natural Fermented Wolfberry, Attenuates Hyperuricaemia in Mice through Modulating Uric Acid Metabolism and Gut Microbiota

Ren,

Wang,

Liu

et al. 2024

Foods

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Hyperuricaemia (HUA) is a disorder of purine metabolism, which manifests itself as an increase in uric acid production and a decrease in uric acid excretion, as well as a change in the structure of the intestinal microbiota. Most of the drugs currently used to treat HUA have significant side effects, and it is essential to find a treatment for HUA that is free of side effects. In this study, a novel strain, Pediococcus acidilactici GQ01, was screened from natural fermented wolfberry. The effects of both live bacteria GQ01 and its heat-killed G1PB postbiotic on HUA were investigated. The results showed that both probiotic GQ01 and G1PB postbiotics could effectively decrease blood uric acid, creatinine, and urea nitrogen levels in the HUA mice model. P. acidilactici GQ01 was more effective in inhibiting ADA activity, while G1PB postbiotics was more effective in inhibiting XOD activity. Meanwhile, GQ01 and G1PB were able to ameliorate liver and kidney tissue injury, upregulate the expression of ABCG2 in kidney and XOD gene in liver, downregulate the protein expression of URAT1 and GLUT9 in kidney, and therefore reduce the value of blood uric acid by decreasing the uric acid reabsorption and increasing the excretion of uric acid. Additionally, both probiotics and postbiotics could regulate the intestinal microbiota structure of HUA mice, so as to bring the dysfunctional intestinal composition back to normal. Furthermore, P. acidilactici GQ01 and G1PB postbiotics can increase the levels of acetic acid, propionic acid, and butyric acid in the intestinal tract, improve the intestinal function, and maintain the healthy homeostatic state of the intestinal tract. In summary, P. acidilactici GQ01 and its G1PB postbiotics may be developed as functional food or drug materials capable of treating HUA.

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Altered Gut Microbiota in Children With Hyperuricemia

Cited by 13 publications

References 55 publications

Causal Relationship between Gut Microbiota and Gout: A Two-Sample Mendelian Randomization Study

Causal Relationship between Gut Microbiota and Gout: A Two-Sample Mendelian Randomization Study

The association between BMI and serum uric acid is partially mediated by gut microbiota

Postbiotic of Pediococcus acidilactici GQ01, a Novel Probiotic Strain Isolated from Natural Fermented Wolfberry, Attenuates Hyperuricaemia in Mice through Modulating Uric Acid Metabolism and Gut Microbiota

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