Altered gut microbiota and activity in a murine model of autism spectrum disorders

Theije, Caroline G. M. de; Wopereis, Harm; Ramadan, Mohamed; Eijndthoven, Tiemen van; Lambert, Jolanda; Knol, Jan; Garssen, Johan; Kraneveld, Aletta D.; Oozeer, Raish

doi:10.1016/j.bbi.2013.12.005

Cited by 358 publications

(273 citation statements)

References 66 publications

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“…For example, anxiety-like or depressive-like behavior in mice was increased after the administration of Campylobacter jejuni and decreased with the use of a Bifidobacterium strain. 7 Furthermore, a pro/ prebiotic-based therapy (e.g., Lactobacillus rhamnosus (JB-1), NCC4007, Bifidobacterium infantis, Bifidobacterium longum NCC3001, RO07, Lactobacillus helveticus R0052, Lactobacillus reuteri and Lactobacillus paracasei) was able to ameliorate the gastrointestinal symptoms that are frequently observed in children with ASDs. 5,54 MET therapy, which employs whole bacterial communities derived directly from the human GI tract (transplantation), showed positive results for different GI diseases (e.g., Clostridium difficile infection).…”

Section: Specific Treatments For Asdsmentioning

confidence: 99%

“…4,5 The GI microbiota under extreme conditions (e.g., in a germ-free environment or during antibiotic treatment) affects the levels of various neurotrophins and monoamine neurotransmitters 6 responsible for brain development and plasticity. 7 Although evidence is accumulating, the role of the GI microbiota in brain disorders is still undefined. An interesting hypothesis concerns the role of the GI microbiota in the pathophysiology of autism spectrum disorders (ASDs).…”

Section: Introductionmentioning

confidence: 99%

“…An interesting hypothesis concerns the role of the GI microbiota in the pathophysiology of autism spectrum disorders (ASDs). 7 ASDs are a group of neurodevelopmental abnormalities that begin in early childhood (although the first diagnosis may sometimes occur later in life) and are characterized by problems in communication and social behavior. According to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which are diagnostic criteria that have recently been released, the major ASD manifestations include impairments in social communication and behavioral problems such as fixated interests and repetitive behaviors.…”

Section: Introductionmentioning

confidence: 99%

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Autism spectrum disorders and intestinal microbiota

et al. 2015

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Section: Specific Treatments For Asdsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Autism spectrum disorders and intestinal microbiota

et al. 2015

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“…Other mechanisms involve changes in the availability of tryptophan and histidine, and consequent alterations in serotonin and histamine in the CNS. 129 Propionic acid, a SFCA that is produced by gut microbiota can also induce significant changes in social development and behavior and create a similar picture to ASD. 130,131 Intraventricular administration of propionic acids to rats can cause structural abnormalities similar to those found in patients with ASD.…”

Section: Emerging Areasmentioning

confidence: 99%

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

Yarandi

Peterson

Treisman

et al. 2016

J Neurogastroenterol Motil

223

134

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Gut microbiome is an integral part of the Gut-Brain axis. It is becoming increasingly recognized that the presence of a healthy and diverse gut microbiota is important to normal cognitive and emotional processing. It was known that altered emotional state and chronic stress can change the composition of gut microbiome, but it is becoming more evident that interaction between gut microbiome and central nervous system is bidirectional. Alteration in the composition of the gut microbiome can potentially lead to increased intestinal permeability and impair the function of the intestinal barrier. Subsequently, neuro-active compounds and metabolites can gain access to the areas within the central nervous system that regulate cognition and emotional responses. Deregulated inflammatory response, promoted by harmful microbiota, can activate the vagal system and impact neuropsychological functions. Some bacteria can produce peptides or short chain fatty acids that can affect gene expression and inflammation within the central nervous system. In this review, we summarize the evidence supporting the role of gut microbiota in modulating neuropsychological functions of the central nervous system and exploring the potential underlying mechanisms.

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“…Immune responses may also cause gastrointestinal (GI) problems through inflammation as well [82]. Various studies have reported the prevalence of GI problems, one of common comorbid conditions of ASD [83,84].…”

Section: Gastrointestinal Microbiota In Asdmentioning

confidence: 99%

Genetic architecture, epigenetic influence and environment exposure in the pathogenesis of Autism

2015

Sci. China Life Sci.

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Autism spectrum disorder (ASD) is a spectral neurodevelopment disorder affecting approximately 1% of the population. ASD is characterized by impairments in reciprocal social interaction, communication deficits and restricted patterns of behavior. Multiple factors, including genetic/genomic, epigenetic/epigenomic and environmental, are thought to be necessary for autism development. Recent reviews have provided further insight into the genetic/genomic basis of ASD. It has long been suspected that epigenetic mechanisms, including DNA methylation, chromatin structures and long non-coding RNAs may play important roles in the pathology of ASD. In addition to genetic/genomic alterations and epigenetic/epigenomic influences, environmental exposures have been widely accepted as an important role in autism etiology, among which immune dysregulation and gastrointestinal microbiota are two prominent ones. autism spectrum disorder, genetic architecture, genomic disorder, gene mutation, copy number variants, single nucleotide variants, genetic pathways, epigenetic influence, DNA methylation, chromatin remodeling, long non-coding RNAs, environment exposure, immune dysregulation, gastrointestinal microbiota Citation:Yu L, Wu YM, Wu BL. Genetic architecture, epigenetic influence and environment exposure in the pathogenesis of Autism. Sci China Life Sci, 2015, 58: 958-967,

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Altered gut microbiota and activity in a murine model of autism spectrum disorders

Cited by 358 publications

References 66 publications

Autism spectrum disorders and intestinal microbiota

Autism spectrum disorders and intestinal microbiota

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

Genetic architecture, epigenetic influence and environment exposure in the pathogenesis of Autism

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