Altered gut microbiota ameliorates bone pathology in the mandible of obese–insulin-resistant rats

Eaimworawuthikul, Sathima; Tunapong, Wannipa; Chunchai, Titikorn; Suntornsaratoon, Panan; Charoenphandhu, Narattaphol; Thiennimitr, Parameth; Chattipakorn, Nipon

doi:10.1007/s00394-019-02002-8

Cited by 18 publications

(9 citation statements)

References 38 publications

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“…Isoflavones are known to decrease the risk of osteoporosis ( Ilesanmi-Oyelere and Kruger, 2020 ). Synbiotics treatment prevented bone loss in the high fat diet-fed rats by preventing osteoclastogenesis and increasing bone formation activities ( Eaimworawuthikul et al, 2020 ). It is observed that synbiotics administration enhanced the level of bone mineral content, BMD, and bone area in broilers subjected to cyclic heat stress episodes ( Yan et al, 2019 ).…”

Section: Dietary Interventions and Modulation Of Gut Microbiotamentioning

confidence: 99%

“Osteomicrobiology”: The Nexus Between Bone and Bugs

et al. 2022

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A growing body of scientific evidence supports the notion that gut microbiota plays a key role in the regulation of various physiological and pathological processes related to human health. Recent findings have now established that gut microbiota also contributes to the regulation of bone homeostasis. Studies on animal models have unraveled various underlying mechanisms responsible for gut microbiota-mediated bone regulation. Normal gut microbiota is thus required for the maintenance of bone homeostasis. However, dysbiosis of gut microbiota communities is reported to be associated with several bone-related ailments such as osteoporosis, rheumatoid arthritis, osteoarthritis, and periodontitis. Dietary interventions in the form of probiotics, prebiotics, synbiotics, and postbiotics have been reported in restoring the dysbiotic gut microbiota composition and thus could provide various health benefits to the host including bone health. These dietary interventions prevent bone loss through several mechanisms and thus could act as potential therapies for the treatment of bone pathologies. In the present review, we summarize the current knowledge of how gut microbiota and its derived microbial compounds are associated with bone metabolism and their roles in ameliorating bone health. In addition to this, we also highlight the role of various dietary supplements like probiotics, prebiotics, synbiotics, and postbiotics as promising microbiota targeted interventions with the clinical application for leveraging treatment modalities in various inflammatory bone pathologies.

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Section: Dietary Interventions and Modulation Of Gut Microbiotamentioning

confidence: 99%

“Osteomicrobiology”: The Nexus Between Bone and Bugs

et al. 2022

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“…Lactobacillus and Bifidobacterium are widely known to be beneficial for bone growth and development 161 ; however, a HFD leads to a reduction in the abundance of the above bacterial genera while also destroying the bone microstructure. Probiotic supplementation can reverse the bone microstructural changes 162,163 …”

Section: Improper Diet the Gm And Bone Metabolismmentioning

confidence: 99%

“…Probiotic supplementation can reverse the bone microstructural changes. 162,163 Asian diets are typically rich in carbohydrates. Relatively few studies have directly investigated the relationship between a high-carbohydrate diet (HCD) and bone metabolism.…”

Section: And Bone Metabolismmentioning

confidence: 99%

Gut microbiota and bone metabolism

Chen

Liu

et al. 2021

The FASEB Journal

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Osteoporosis is the most common metabolic skeletal disease. It is characterized by the deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even bone fractures. Accumulating evidence has indicated that there is an inextricable relationship between the gut microbiota (GM) and bone homeostasis involving host–microbiota crosstalk. Any perturbation of the GM can play an initiating and reinforcing role in disrupting the bone remodeling balance during the development of osteoporosis. Although the GM is known to influence bone metabolism, the mechanisms associated with these effects remain unclear. Herein, we review the current knowledge of how the GM affects bone metabolism in health and disease, summarize the correlation between pathogen‐associated molecular patterns of GM structural components and bone metabolism, and discuss the potential mechanisms underlying how GM metabolites regulate bone turnover. Deciphering the complicated relationship between the GM and bone health will provide new insights into the prevention and treatment of osteoporosis.

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“…The studies by Uchida and Irie reported that commensal gut microbiota-colonized mice showed increased alveolar bone loss and compromised trabecular morphology compared with GF mice ( Irie et al., 2018 ; Uchida et al., 2018 ). Compared to the rats with normal diet, obese-insulin-resistant rats fed with high-fat diet presented with enhanced osteoclast-mediated bone resorption, decreased jawbone mineral density, as well as impaired jawbone microarchitecture, and the jawbone morphology could be improved by the administration of probiotics, prebiotics, or symbiotics supplements ( Eaimworawuthikul et al., 2019 ; Eaimworawuthikul et al., 2020 ) ( Table 1 ).…”

Section: Gut Microbiota and Bone Healthmentioning

confidence: 99%

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Jia

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health via regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.

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Altered gut microbiota ameliorates bone pathology in the mandible of obese–insulin-resistant rats

Cited by 18 publications

References 38 publications

“Osteomicrobiology”: The Nexus Between Bone and Bugs

“Osteomicrobiology”: The Nexus Between Bone and Bugs

Gut microbiota and bone metabolism

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

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