Altered gray matter structural covariance networks in postpartum depression: a graph theoretical analysis

Li, Yuna; Chu, Tongpeng; Che, Kaili; Dong, Fanghui; Shi, Ying‐Hong; Ma, Heng; Zhao, Feng; Mao, Ning; Xie, Haizhu

doi:10.1016/j.jad.2021.05.018

Cited by 12 publications

(16 citation statements)

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“…The results of structural MRI studies of PPD are inconsistent. One structural study detected the changes of the white matter structure in various brain regions (e.g., parietal, occipital, temporal, and frontal cortices) ( 38 ), while other studies ( 39 ) suggested structural connectivity alterations in the DMN, the CCN or the visual system, the surface-area increase in the frontal lobe and temporal lobe ( 40 ) or increase of the GM volume in the dlPFC and the insula ( 41 ). We provide more detailed results of each identified structural MRI study below.…”

Section: Resultsmentioning

confidence: 99%

“…Li et al ( 39 ) investigated brain structural covariance networks that enables to characterize the topological properties of the brain organization presumably associated with the PPD structural pathophysiology. There was a PPD-related hub in the inferior parietal lobule (IPL).…”

Section: Resultsmentioning

confidence: 99%

“…It is noteworthy that several studies, namely by Cheng et al ( 21 , 24 , 25 ), and Li et al ( 39 , 40 ) respectively, were conducted by the same group of authors within their longitudinal perinatal projects, using overlapping study samples, but different statistical approaches. For instance, Cheng et al ( 21 ) performed the analysis of Functional Connectivity Strength (FCS) in the first study, the analysis of Functional Connectivity Density (FCD) in the second ( 25 ), and the dynamic and static Functional Connectivity analysis in the third study ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

“…This can be attributed to the fact that the majority of newly included studies were performed during resting-state when the activity of the DMN is predominating over the activity of other networks (18,20,21,23,24). Moreover, the recent structural studies were also focused on the DMN structures and were able to corroborate their abnormalities in women with PPD (39,40). Other currently reviewed studies additionally identified PPD structural correlates in the SN, particularly in the insular cortex, as women with PPD showed increased regional GM volume and increased surface area (40,41).…”

Section: Comparison To the Previous Comprehensive Reviewmentioning

confidence: 99%

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Structural, functional, and metabolic signatures of postpartum depression: A systematic review

et al. 2022

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ObjectivePostpartum depression (PPD) is a serious condition with debilitating consequences for the mother, offspring, and the whole family. The scope of negative outcomes of PPD highlights the need to specify effective diagnostics and treatment which might differ from major depressive disorder (MDD). In order to improve our clinical care, we need to better understand the underlying neuropathological mechanisms of PPD. Therefore, we conducted a systematic review of published neuroimaging studies assessing functional, structural, and metabolic correlates of PPD.MethodsRelevant papers were identified using a search code for English-written studies in the PubMed, Scopus, and Web of Science databases published by March 2022. Included were studies with structural magnetic resonance imaging, functional magnetic resonance imaging, both resting-state and task-related, magnetic resonance spectroscopy, or positron emission tomography. The findings were analyzed to assess signatures in PPD-diagnosed women compared to healthy controls. The review protocol was registered in PROSPERO (CRD42022313794).ResultsThe total of 3,368 references were initially identified. After the removal of duplicates and non-applicable papers, the search yielded 74 full-text studies assessed for eligibility. Of them, 26 met the inclusion criteria and their findings were analyzed and synthesized. The results showed consistent functional, structural, and metabolic changes in the default mode network and the salient network in women with PPD. During emotion-related tasks, PPD was associated with changes in the corticolimbic system activity, especially the amygdala.DiscussionThis review offers a comprehensive summary of neuroimaging signatures in PPD-diagnosed women. It indicates the brain regions and networks which show functional, structural, and metabolic changes. Our findings offer better understanding of the nature of PPD, which clearly copies some features of MDD, while differs in others.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Comparison To the Previous Comprehensive Reviewmentioning

confidence: 99%

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Structural, functional, and metabolic signatures of postpartum depression: A systematic review

et al. 2022

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“…The SCN analysis based on morphological indices such as the gray matter volume and cortical thickness is considered to correspond with anatomical connectivity and can reflect the accurate coordination of cortical morphology (22, 23). Thus, using brain gray matter anatomy to investigate structural networks in cognitive disorders may be more stable and convincing to some degree (24) and has been widely applied in a variety of neuropsychiatric diseases nowadays (23,(25)(26)(27)(28).…”

Section: Introductionmentioning

confidence: 99%

Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals

Gao²,

Wang³

et al. 2022

Front. Neurol.

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BackgroundWhile regional brain structure and function alterations in HIV-infected individuals have been reported, knowledge about the topological organization in gray matter networks is limited. This research aims to investigate the effects of early HIV infection and combination antiretroviral therapy (cART) on gray matter structural covariance networks (SCNs) by employing graph theoretical analysis.MethodsSixty-five adult HIV+ individuals (25–50 years old), including 34 with cART (HIV+/cART+) and 31 medication-naïve (HIV+/cART–), and 35 demographically matched healthy controls (HCs) underwent high-resolution T1-weighted images. A sliding-window method was employed to create “age bins,” and SCNs (based on cortical thickness) were constructed for each bin by calculating Pearson's correlation coefficients. The group differences of network indices, including the mean nodal path length (Nlp), betweenness centrality (Bc), number of modules, modularity, global efficiency, local efficiency, and small-worldness, were evaluated by ANOVA and post-hoc tests employing the network-based statistics method.ResultsRelative to HCs, less efficiency in terms of information transfer in the parietal and occipital lobe (decreased Bc) and a compensated increase in the frontal lobe (decreased Nlp) were exhibited in both HIV+/cART+ and HIV+/cART– individuals (P < 0.05, FDR-corrected). Compared with HIV+/cART– and HCs, less specialized function segregation (decreased modularity and small-worldness property) and stronger integration in the network (increased Eglob and little changed path length) were found in HIV+/cART+ group (P < 0.05, FDR-corrected).ConclusionEarly HIV+ individuals exhibited a decrease in the efficiency of information transmission in sensory regions and a compensatory increase in the frontal lobe. HIV+/cART+ showed a less specialized regional segregation function, but a stronger global integration function in the network.

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Altered MRI Diffusion Properties of the White Matter Tracts Connecting Frontal and Thalamic Brain Regions in First‐Episode, Drug‐Naïve Patients With Postpartum Depression

Long

Zhou

Zhang

et al. 2022

Magnetic Resonance Imaging

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Background Although progress has been made in exploring postpartum depression (PPD), the involvement of cerebral structure connectivity in PPD patients keeps unclear. Purpose To explore structural connectivity alternations in mothers with PPD, diffusion tensor imaging (DTI) and automated fiber quantification (AFQ) were used to calculate brain white matter microstructure properties. Study Type Cross‐sectional. Population A total of 51 women with first‐episode, treatment‐näive PPD, and 49 matched healthy postpartum women (HPW) controls. Field Strength A 3.0 T; single‐shot echo‐planar imaging sequence. Assessment DTI measurements of fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) were obtained for 18 specific white matter tracts. The relationship between PDD symptoms, hormone levels, and postpartum days was also investigated. Statistical Tests Two sample t test and Pearson's correlation analysis. The analysis was performed by using a permutation‐based multiple‐comparison correction approach, with the threshold of P < 0.05 (family wise error corrected [FWE‐corrected]) separately across the four different outcome measures. Results Women with PPD showed significantly increased FA and AD in right anterior thalamic radiation (ATR) tract and significantly increased FA and significantly reduced RD in the cingulum tract, compared to women without PPD. The RD values of right cingulum were significantly positively correlated with postpartum days in HPW (r = 0.39). There were no significant relationships between brain measures and hormone levels in either patients or controls. Data Conclusions DTI measures have revealed altered integrity in the white matter of the cortical‐thalamic circuits in women with PPD compared to HPW. Damage to these circuits may be a structural basis for the impaired emotional regulation and blunted mother–infant bonding in mothers with PPD and a potential target for the development of new treatments. Evidence Level 2 Technical Efficacy Stage 3

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Altered gray matter structural covariance networks in postpartum depression: a graph theoretical analysis

Cited by 12 publications

References 68 publications

Structural, functional, and metabolic signatures of postpartum depression: A systematic review

Structural, functional, and metabolic signatures of postpartum depression: A systematic review

Altered gray matter structural covariance networks in drug-naïve and treated early HIV-infected individuals

Altered MRI Diffusion Properties of the White Matter Tracts Connecting Frontal and Thalamic Brain Regions in First‐Episode, Drug‐Naïve Patients With Postpartum Depression

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