Altered glutathione system is associated with the presence of distal symmetric peripheral polyneuropathy in type 2 diabetic subjects

Mendez, Mercedes Molina; Folgado, José; Tormo, Carmen; Artero, Ana; Ascaso, María; Martínez-Hervás, Sergio; Chaves, Felipe Javier; Ascaso, Juan F.; Real, José T.

doi:10.1016/j.jdiacomp.2015.05.023

Cited by 21 publications

(16 citation statements)

References 35 publications

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“…Secondary risk factors are smoking and prediabetes [1,21,60,63]. Platelet activation [79][80][81][82], oxidative stress [65][66][67][68][69][70][71][72][73][74], low vitamin D [83,84], insulin resistance [58], and genetic factors [100][101][102][103][104][105][106] play another supplementary role, but, for the time being, there are limited options for intervention. A suggestion for targeting insulin resistance originates from the study by Pop-Busui et al, showing that reduced incident DSPN is less frequent in T2D patients receiving insulin-sensitizing oral agents (66%) than in those receiving insulinproviding treatment (66% vs. 72%, respectively, p = 0.02) [155].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have reported associations between systemic markers of oxidative stress and DSPN in diabetic patients. For example, lower values of reduced glutathione and reduced glutathione/oxidized glutathione ratio in association with DSPN have been reported [69]. Lower plasma concentrations of nitric oxide and higher endogenous oxidative DNA damage in T2D patients with DSPN have also been observed [70].…”

Section: Oxidative Stressmentioning

confidence: 98%

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Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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■ AbstractDistal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral artery disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Oxidative Stressmentioning

confidence: 98%

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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“…Increased systemic generation of superoxide anion, higher levels of the protein carbonylation marker methylglyoxal, and lower levels of the antioxidant biomarkers reduced glutathione and glutathione peroxidase in peripheral blood mononuclear cells or serum/plasma have been linked to the presence of DSPN. [12][13][14][15] These data point to an imbalance between prooxidant substances and antioxidant capacity in peripheral blood. However, other studies failed to confirm some of these findings.…”

Section: Associations Between Biomarkers Of Oxidative Stress and Dspnmentioning

confidence: 99%

“…Associations between biomarkers of oxidative stress and DSPN have mainly been assessed in small cross‐sectional studies. Increased systemic generation of superoxide anion, higher levels of the protein carbonylation marker methylglyoxal, and lower levels of the antioxidant biomarkers reduced glutathione and glutathione peroxidase in peripheral blood mononuclear cells or serum/plasma have been linked to the presence of DSPN . These data point to an imbalance between prooxidant substances and antioxidant capacity in peripheral blood.…”

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase, superoxide dismutase‐3, cardiometabolic risk factors, and distal sensorimotor polyneuropathy: The KORA F4/FF4 study

Herder

Kannenberg

Huth

et al. 2018

Diabetes Metabolism Res

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“…1 Bu bilgileri ışığında, literatürde oksidan/antioksidan sis-temde rol alan belirteçler ile T2DM hastalığı arasındaki ilişkiyi araştıran çok sayıda çalışmanın bulunduğunu ancak bu araştırmalarda çelişkili bulguların var olduğu görülmüştür. [3][4][5][8][9][10][11][12][13]…”

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Komplikasyonlu ve Komplikasyonsuz Tip 2 Diyabetik Hastalarda Antioksidanlar ve Lipid Peroksidasyon Durumu

Hacıoğlu¹,

Bahtiyar²

2019

Sakarya Medical Journal

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Amaç Çalışmamızda Tip 2 diabetes mellitus (T2DM) hastalığına bağlı vasküler komplikasyon gelişiminde malondialdehit (MDA), katalaz (KAT), süperoksit dismutaz (SOD) ve glutatyon (GSH) düzeylerinin olası değişimlerinin incelenmesi amaçlandı. Gereç ve Yöntemler Çalışmaya vasküler komplikasyonu olan 35 T2DM hastası (Komp (+) T2DM grubu), vasküler komplikasyonu olmayan 35 T2DM hastası (Komp (-) T2DM grubu) ve 30 sağlıklı birey (Kontrol grubu) dahil edildi. Tüm bireylerin plazma MDA, KAT, SOD ve GSH düzeyleri ölçüldü. Bulgular MDA ve KAT düzeylerinin T2DM, Komp (-) T2DM, ve Komp (+) T2DM gruplarında kontrol grubuna göre arttığı görüldü (tümü için p<0,001). Ayrıca Komp (+) T2DM grubunun MDA ve KAT düzeyleri, Komp (-) T2DM grubuna göre artmış olduğu gözlemlendi (sırasıyla (p<0,001, p=0,001). SOD düzeylerinin T2DM, Komp (-) T2DM, ve Komp (+) T2DM gruplarında kontrol grubuna göre, Komp (+) T2DM grubunda Komp (-) T2DM grubuna göre azaldığı görüldü (sırasıyla p<0,001, p=0,002, p<0,001 ve p=0,003). T2DM ve Komp (+) T2DM gruplarının kontrol grubuna göre plazma GSH değerlerinin düşük olduğu bulundu (sırasıyla p=0,011, 0,004). Komplikasyon gelişimine göre belirteçler arasındaki ilişki incelendiğinde; Komp (+) T2DM grubunda Açlık kan şekeri (AKŞ) ile HbA1c ve MDA; HbA1c ile MDA; SOD ile KAT arasında pozitif korelasyon olduğu, AKŞ ile SOD, KAT ve GSH; HbA1c ile SOD, KAT ve GSH; MDA ile SOD ve KAT; SOD ile KAT arasında negatif bir korelasyon olduğu görüldü. Sonuç Çalışmamızın bulguları incelediğimiz oksidatif stres belirteçlerinin T2DM patogenezinde ve vasküler komplikasyon gelişiminde yer aldığını göstermektedir. T2DM hastalığı patogenezi ve progresyonunda oksidan seviyelerin rolünü ve ilişkili mekanizmaların belirlenmesi için ileri çalışmalara ihtiyaç duyulmaktadır.

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Altered glutathione system is associated with the presence of distal symmetric peripheral polyneuropathy in type 2 diabetic subjects

Cited by 21 publications

References 35 publications

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Myeloperoxidase, superoxide dismutase‐3, cardiometabolic risk factors, and distal sensorimotor polyneuropathy: The KORA F4/FF4 study

Komplikasyonlu ve Komplikasyonsuz Tip 2 Diyabetik Hastalarda Antioksidanlar ve Lipid Peroksidasyon Durumu

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