Altered Genome-Wide DNA Methylation in the Duodenum of Common Variable Immunodeficiency Patients
Mingyi Yang,
Mari Kaarbø,
Vegard Myhre
et al.
Abstract:Purpose
A large proportion of Common variable immunodeficiency (CVID) patients has duodenal inflammation with increased intraepithelial lymphocytes (IEL) of unknown aetiology. The histologic similarities to celiac disease, lead to confusion regarding treatment (gluten-free diet) of these patients. We aimed to elucidate the role of epigenetic DNA methylation in the aetiology of duodenal inflammation in CVID and differentiate it from true celiac disease.
Methods
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