Altered gastrointestinal tract structure and microbiome following cerebral malaria infection

Mechanistic insights into the interaction between the host gut microbiome and malaria

“…Knowler and colleagues (2023) observed lengthening of small intestine in contrast to Shimada and colleagues (2019) [60,63]. P. berghei ANKA infection in C57BL/6 mice caused changes in gut bacteria composition with increased abundance of class Clostridia; family Enterobacteriaceae, Verrucomicrobiaceae; and genus Akkermansia, Alistipes, and Alloprevotella and decrease Lactobacillaceae family (Fig 2) [59,60,62]. Although P. berghei ANKA causes lethal ECM within 7 to 10 days, these P. berghei ANKA-induced changes in gut bacterial composition were long lasting if mice were treated with artemether [61].…”

“…ECM caused weight loss, multiple red gastric patches, detachment of epithelia, gastric gas retention, enlargement of goblet cells, small intestine shortening, increased intestinal permeability, and caused dysbiosis [ 63 ]. Knowler and colleagues (2023) observed lengthening of small intestine in contrast to Shimada and colleagues (2019) [ 60 , 63 ]. P .…”

“…ECM caused weight loss, multiple red gastric patches, detachment of epithelia, gastric gas retention, enlargement of goblet cells, small intestine shortening, increased intestinal permeability, and caused dysbiosis [63]. Knowler and colleagues (2023) observed lengthening of small intestine in contrast to Shimada and colleagues (2019) [60,63]. P. berghei ANKA infection in C57BL/6 mice caused changes in gut bacteria composition with increased abundance of class Clostridia; family Enterobacteriaceae, Verrucomicrobiaceae; and genus Akkermansia, Alistipes, and Alloprevotella and decrease Lactobacillaceae family (Fig 2) [59,60,62].…”

“…P . berghei ANKA infection in C57BL/6 mice caused changes in gut bacteria composition with increased abundance of class Clostridia; family Enterobacteriaceae , Verrucomicrobiaceae ; and genus Akkermansia , Alistipes , and Alloprevotella and decrease Lactobacillaceae family ( Fig 2 ) [ 59 , 60 , 62 ]. Although P .…”

“…Nearly a quarter of cerebral malaria survivors suffer from life-long neurological sequelae and ongoing comorbidities [58]. Five studies have investigated the impact of experimental cerebral malaria (ECM) on gut microbiome composition in murine malaria [59][60][61][62] and one on upper gastrointestinal pathophysiology [63] with variable results. Taniguchi and colleagues (2015) and Shimada and colleagues (2019) reported intestinal pathology in C57BL/6 mice infected by P. berghei ANKA that develop ECM [62,63].…”