Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia

Hashemi Karoii, Danial; Azizi, Hossein; Skutella, Thomas

doi:10.1089/dna.2023.0189

Cited by 6 publications

(1 citation statement)

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“…A high quality and relevance of gene prioritization can be seen in this network, which contains five of the eight canonical markers. As well as finding novel regulators of SSC self-renewal, we suggest the refined network could be used to identify target genes for male infertility and testicular cancer treatment [16,29,[31][32][33]. DOI: http://dx.doi.org/10.5772/intechopen.112964…”

Section: Spermatogonia Stem Cell Gene Ontology and Signaling Pathway ...mentioning

confidence: 99%

Undifferentiated and Differentiated Spermatogonial Stem Cells

Hashemi Karoii,

Azizi

2024

Biochemistry

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Spermatogenesis is initiated and sustained by a rare population of singular spermatogonial stem cells (SSCs). These SSCs are connected to the basement membrane of the seminiferous tubules and possess distinctive morphological characteristics. They serve as a vital foundation for a robust stem cell system within the testis, crucial for spermatogenesis and reproductive processes. The isolation and cultivation of human SSCs would significantly enhance our understanding of germ and stem cell biology in humans. Although a challenging endeavor, the recent advancements in enriching and propagating spermatogonia carrying the male genome offer a significant stride toward future transplantation and the restoration of fertility in clinical settings.

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Section: Spermatogonia Stem Cell Gene Ontology and Signaling Pathway ...mentioning

confidence: 99%