Altered Functional Network in Infants With Profound Bilateral Congenital Sensorineural Hearing Loss: A Graph Theory Analysis

Cui, Wenzhuo; Wang, Shanshan; Chen, Boyu; Fan, Guoguang

doi:10.3389/fnins.2021.810833

Cited by 6 publications

(5 citation statements)

References 78 publications

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“…The present study found that both TD and congenital SNHL infants exhibited a higher local efficiency but numerically approximate global efficiency compared with their matched random networks, which is a typical characteristic of small-worldness. The findings of the current study are consistent with previous demonstrations that both the SNHL group and NH group showed small-word organization, with no significant differences between them (Cui et al 2022). These results demonstrate that the capability of both local specialization and global integration within cerebral networks has emerged and been maintained in TD infants and has not yet been disrupted in the youngest infants with congenital SNHL.…”

Section: Economic Small-world Characteristics Of the Cerebral Network...supporting

confidence: 93%

Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

Liu

Zhou

et al. 2023

Preprint

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Auditory exposure plays crucial roles in shaping healthy brain development and generating lateralization of functional network organization. However, little is known about whether and how an initial lack of auditory exposure in early infancy may disrupt development of functional network lateralization. We addressed this issue by recruiting 55 infants with congenital sensorineural hearing loss (SNHL) and 60 typically developing (TD) controls. Resting-state fNIRS imaging data were acquired to construct hemispheric cerebral networks, and graph theory was applied to quantify the topological characteristics of hemispheric networks. The infants with SNHL exhibited efficient small-world characteristic within each hemispheric network, however, the lateralization of functional network efficiency was substantially disrupted. Compared with TD infants with significantly increased network efficiency lateralized toward left hemisphere with age, the SNHL infants did not exhibit the emergence and development of such cerebral lateralization. Furthermore, the increased leftward asymmetry in nodal efficiency with age was found in TD but not in SNHL infants. Interestingly, the degree of hearing loss had no correlation with lateralization strength in the SNHL group. These results suggest that SNHL infants exhibited disrupted development of cortical lateralization in functional network organization, and highlight the importance of auditory stimulation-promoted multisensory functional integration in early infancy.

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Section: Economic Small-world Characteristics Of the Cerebral Network...supporting

confidence: 93%

Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

Liu

Zhou

et al. 2023

Preprint

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“…The activation in the right middle temporal gyrus may be related to cognitive conflict in the decision task. The middle temporal gyrus is involved in visual processes, specifically in action observation ( Cui et al, 2021 ). The presence of conflict or competition between different options during the decision process may lead to decision difficulty.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of brain activation in high-level football players at different stages of decision-making tasks off the ball: an fMRI study

Huang,

Lang,

et al. 2023

Front. Hum. Neurosci.

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ObjectiveThis study aimed to examine the neural mechanisms underlying the decision-making process of off-ball movements among high-level football players and ordinary college students, as well as the effect of long-term skill training on these neural mechanisms using functional magnetic resonance imaging (fMRI).MethodsThe study recruited 20 professional college football players as the expert group (EG) and 20 novice football players with no background in sports-related disciplines as the novice group (NG). The participants performed the motor video observation and button-decision-making tasks, and fMRI data were acquired, pre-processed, and analyzed.ResultsDuring the decision-making process regarding running without the ball, whole-brain fMRI scans were conducted on both the EG and NG. The analysis of these scans revealed noteworthy disparities in brain activity between the two groups. These disparities were observed during tasks involving motor video observation and button-based decision-making. According to the behavioral data, the EG made more correct decisions than the NG (p < 0.05); however, there was no significant difference in their reaction speed (p > 0.05). During video observation, both the EG and NG exhibited simultaneous activation in the frontoparietal cognitive area, primary somatosensory cortex, visual cortex, and insula. However, there were no significant differences between the two groups in terms of activated brain regions [false discovery rate (FDR) corrected to p < 0.05]. Regarding button-press decisions, the areas of the brain that were commonly activated in both the NG and EG were primarily located in the frontoparietal cognitive area, temporal cortex, and cuneus cortex. Notably, the left superior temporal gyrus, left inferior temporal gyrus, and left middle occipital gyrus exhibited greater activation in the NG compared to those in the EG (FDR corrected to p < 0.05).ConclusionThis study demonstrated that during motor video observation, the EG’s sports experience and professional knowledge can help them achieve better visual information processing strategies in specific areas of sports. During button decision-making, the EG was more economical, whereas the NG required more brain function activity to process visual information, confirming the “neural efficiency” hypothesis.

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“…Resting-state functional MRI (rs-fMRI) ( 16) is an advanced non-invasive magnetic resonance imaging technique that assesses regional brain activity and functional connectivity by measuring low-frequency spontaneous blood oxygen level-dependent signals, and low-frequency fluctuation (ALFF), regional homogeneity (ReHo) and functional connectivity (FC) are good neural markers for brain imaging. Therefore, researchers have used rs-fMRI and these neural markers to explore the reorganization of cerebral cortex in deaf patients (17)(18)(19). For example Wang et al (20) found that children with CSNHL had abnormal changes in ReHo values in local brain regions, indicating that deafness had an impact on brain functional activity in children.…”

Section: Introductionmentioning

confidence: 99%

Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study

Yin,

Lyu,

Zhou

et al. 2024

Front. Neurol.

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PurposeHow cortical functional reorganization occurs after hearing loss in preschool children with congenital sensorineural hearing loss (CSNHL) is poorly understood. Therefore, we used resting-state functional MRI (rs-fMRI) to explore the characteristics of cortical reorganization in these patents.MethodsSixty-three preschool children with CSNHL and 32 healthy controls (HCs) were recruited, and the Categories of Auditory Performance (CAP) scores were determined at the 6-month follow-up after cochlear implantation (CI). First, rs-fMRI data were preprocessed, and amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were calculated. Second, whole-brain functional connectivity (FC) analysis was performed using bilateral primary auditory cortex as seed points. Finally, Spearman correlation analysis was performed between the differential ALFF, ReHo and FC values and the CAP score.ResultsALFF analysis showed that preschool children with CSNHL had lower ALFF values in the bilateral prefrontal cortex and superior temporal gyrus than HCs, but higher ALFF values in the bilateral thalamus and calcarine gyrus. And correlation analysis showed that some abnormal brain regions were weak negatively correlated with CAP score (p < 0.05). The ReHo values in the bilateral superior temporal gyrus, part of the prefrontal cortex and left insular gyrus were lower, whereas ReHo values in the bilateral thalamus, right caudate nucleus and right precentral gyrus were higher, in children with CSNHL than HCs. However, there was no correlation between ReHo values and the CAP scores (p < 0.05). Using primary auditory cortex (PAC) as seed-based FC further analysis revealed enhanced FC in the visual cortex, proprioceptive cortex and motor cortex. And there were weak negative correlations between the FC values in the bilateral superior temporal gyrus, occipital lobe, left postcentral gyrus and right thalamus were weakly negatively correlated and the CAP score (p < 0.05).ConclusionAfter auditory deprivation in preschool children with CSNHL, the local functions of auditory cortex, visual cortex, prefrontal cortex and somatic motor cortex are changed, and the prefrontal cortex plays a regulatory role in this process. There is functional reorganization or compensation between children’s hearing and these areas, which may not be conducive to auditory language recovery after CI in deaf children.

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Altered Functional Network in Infants With Profound Bilateral Congenital Sensorineural Hearing Loss: A Graph Theory Analysis

Cited by 6 publications

References 78 publications

Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

Characteristics of brain activation in high-level football players at different stages of decision-making tasks off the ball: an fMRI study

Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study

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