Altered Functional Connectivity of the Marginal Division in Alzheimer’s Disease

Zhang, Zengqiang; Liu, Yong; Zhou, Bo; Zheng, Junnian; Yao, Hongxiang; An, Ning; Wang, Pan; Guo, Yane; Dai, Haitao; Wang, Luning; Shu, Shijie; Zhang, Xi; Jiang, Tianzi

doi:10.2174/1567205011666140110112608

Cited by 23 publications

(26 citation statements)

References 79 publications

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“…Data from some of the subjects examined in the present study have been reported in our previous studies of regional homogeneity , amygdalar connectivity , thalamic connectivity , and marginal division connectivity (Zhang et al, 2014) during resting states. All of the subjects met identical methodological stringency criteria, and comprehensive clinical details can be found in our prior work Zhang et al, 2012Zhang et al, , 2014Zhou et al, 2013).…”

Section: Methodsmentioning

confidence: 82%

“…All of the subjects met identical methodological stringency criteria, and comprehensive clinical details can be found in our prior work Zhang et al, 2012Zhang et al, , 2014Zhou et al, 2013). Notably, all of the analyses attempted in this study are fully orthogonal to any previously published effects that are based on the AD and MCI replication samples and thus ensure the independence of the reported effects.…”

Section: Methodsmentioning

confidence: 98%

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Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Yao

Zhou²,

Zhang³

et al. 2014

Brain Connectivity

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Mild cognitive impairment (MCI) is considered to be the prodromal stage of Alzheimer's disease. The amygdala, which is considered to be a hub, has been shown to have widespread brain connections with many cortical regions. Longitudinal alterations in the functional connectivity of the amygdala remain unclear in MCI. We hypothesized that the impairment in the amygdala-cortical loop would be more severe in a follow-up MCI group than in a baseline MCI group and that these alterations would be related to the disease processes. To test this hypothesis, we used resting-state functional magnetic resonance imaging to investigate alterations in amygdalar connectivity patterns based on longitudinal data from 13 MCI subjects (8 males and 5 females). Compared to the baseline, decreases in functional connectivity were mainly found located between the amygdala and regions at the conjunction of the temporal-occipital system and the regions included in the default mode network in the follow-up MCI individuals. The alterations in the functional connectivity of the identified regions were validated in an independent dataset. Specifically, reduced amygdalar connectivity was significantly correlated with cognitive abilities. These findings indicate that impairments in the functional connectivity of the amygdala may be potential biomarkers of the progression of MCI.

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Section: Methodsmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 98%

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Yao

Zhou²,

Zhang³

et al. 2014

Brain Connectivity

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“… [76] c, †6235122372.48.527161169.26.5xx3.0 T GESBT Zhang et al. [77] c, †6235122372.48.527161169.26.5x3.0 T GESBMrD (l, r)Gour et al. [29]28146875.12.91441072.83.0xx3.0 T SSBPCC, perirhinal cortex (l, r), dlPFC (l, r)Weiler et al.…”

Section: Resultsmentioning

confidence: 99%

Resting‐state network dysfunction in Alzheimer's disease: A systematic review and meta‐analysis

Badhwar

Tam

Christian

et al. 2017

Alz & Dem Diag Ass & Dis Mo

327

256

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IntroductionWe performed a systematic review and meta-analysis of the Alzheimer's disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment, using resting-state functional magnetic resonance imaging.MethodsStudies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies.ResultsThirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and limbic networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific examination of the default mode network.DiscussionConvergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD. The locations of consistent alterations suggest that highly connected hub regions in the brain might be an early target of AD.

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“…For example, gray matter (GM) atrophy of the cerebellum was detected in AD in several neuroimaging studies (Thomann et al, 2008; Bas et al, 2009). In addition, the AD patients exhibited significantly lower cerebral blood flow (CBF; Hauser et al, 2013), abnormal activation during Stroop tests (Kaufmann et al, 2008) and impaired rsFCs of the cerebellum (Wang et al, 2007; Zhang et al, 2014) in several studies. Furthermore, the AD pathological changes have now been revealed in the cerebellum including deposits of amyloid-β plaques, neurofibrillary tangles, increased microglia and so on (Larner, 1997; Ciavardelli et al, 2010; Sepulveda-Falla et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Alzheimer’s Disease

Zheng

Liu

Song

et al. 2017

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is the most common cause of dementia. Previous studies have found disrupted resting state functional connectivities (rsFCs) in various brain networks in the AD patients. However, few studies have focused on the rsFCs of the cerebellum and its sub-regions in the AD patients. In this study, we collected resting-state functional magnetic resonance imaging (rs-fMRI) data including 32 AD patients and 38 healthy controls (HCs). We selected two cognitive-related subregions of the cerebellum as seed region and mapped the whole-brain rsFCs for each subregion. We identified several distinct rsFC patterns of the two cognitive-related cerebellar subregions: default-mode network (DMN), frontoparietal network (FPN), visual network (VN) and sensorimotor network (SMN). Compared with the controls, the AD patients showed disrupted rsFCs in several different networks (DMN, VN and SMN), predicting the impairment of the functional integration in the cerebellum. Notably, these abnormal rsFCs of the two cerebellar subregions were closely associated with cognitive performance. Collectively, we demonstrated the distinct rsFCs patterns of cerebellar sub-regions with various functional networks, which were differentially impaired in the AD patients.

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Altered Functional Connectivity of the Marginal Division in Alzheimer’s Disease

Cited by 23 publications

References 79 publications

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Longitudinal Alteration of Amygdalar Functional Connectivity in Mild Cognitive Impairment Subjects Revealed by Resting-State fMRI

Resting‐state network dysfunction in Alzheimer's disease: A systematic review and meta‐analysis

Altered Functional Connectivity of Cognitive-Related Cerebellar Subregions in Alzheimer’s Disease

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