Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study

Yan, Xiao‐Xin; Wang, Yun; Xu, Lijuan; Liu, Yong; Song, Seung Yeon; Ding, Kun; Zhou, Yuan; Jiang, Tianzi; Lin, Xiaoming

doi:10.1080/02713683.2018.1540642

Cited by 29 publications

(30 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Emerging evidence highlighted the importance of cortical dysfunction in the progress of strabismus and binocular dysfunction 4–6 . Previous studies have confirmed functional maladaptation in the primary visual cortex in strabismus and strabismic amblyopia using resting‐state functional magnetic resonance imaging (rs‐fMRI) 7,8 . Recent work indicated that the extrastriate cortex may also be aberrant 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Disrupted neural signals in patients with concomitant exotropia

Yao

Zhang

et al. 2020

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

Purpose Decreased binocular and oculomotor function in strabismics has recently been considered as cortical in origin. This study aimed to investigate functional abnormalities using a frequency‐specific neuroimaging method in patients with concomitant exotropia (XT), and to demonstrate the clinical implications. Methods Resting‐state functional magnetic resonance imaging data were collected in 26 XT patients and 26 matched controls. To evaluate the local spontaneous neural activity, the amplitude of low frequency fluctuations (ALFF) was calculated in the typical frequency band (0.01–0.08 Hz) as well as five narrowly‐defined frequency bands (slow‐6: 0–0.01 Hz, slow‐5: 0.01–0.027 Hz, slow‐4: 0.027–0.073 Hz, slow‐3: 0.073–0.167 Hz, and slow‐2: 0.167–0.25 Hz), respectively. Results Patients with XT showed decreased ALFF in the bilateral parieto‐occipital sulcus (POS), and increased ALFF in the bilateral thalamus within the typical frequency band. Frequency‐dependent ALFF alterations were found in the higher visual areas such as the right lateral occipital complex (LOC). Furthermore, ALFF in the right LOC in the slow‐5 band was positively correlated with fusion control score (r = 0.70, p < 0.0001) and binocular function score (r = 0.67, p = 0.0002). Regression analyses showed that early age of onset remained the only significant explanatory factor for ALFF reduction in the right POS in the typically‐measured frequency band (also referred to as the typical frequency band) (Odds ratio, 0.038; 95% confidence interval, 0.001 to 0.075). Conclusions Our findings provide spatial information regarding the functionally disrupted regions in XT. Moreover, the frequency‐dependent ALLF alteration in the right LOC might reflect a potential plastic capacity in binocular function, which could be a potential objective index for evaluating disease severity.

show abstract

Section: Introductionmentioning

confidence: 99%

Disrupted neural signals in patients with concomitant exotropia

Yao

Zhang

et al. 2020

Ophthalmic Physiologic Optic

View full text Add to dashboard Cite

show abstract

“…Previous studies investigating ophthalmological diseases (Table 4) revealed abnormal spontaneous FC between the V1 and other regions in patients with anisometropic amblyopia, 12 blindness, [13][14][15] glaucoma, 8,16,7,16 exotropia, 10,9 acute open globe injury, 17 and retinitis pigmentosa. 18 The FC in the left V1 and right FG, bilateral cuneus, and left precuneus was significantly decreased in the NVG group compared with that reported in the HC group ( Figure 5).…”

Section: Discussionmentioning

confidence: 87%

“…33 A decrease in the FC value of the precuneus was also observed in patients with anisometropic amblyopia 12 and comitant exotropia. 10,9 A study showed that individual sensitivity to pain varies depending on precuneus reactivity. 34 This is consistent with the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

“…It is the most extensively used technique on account of its sensitivity, simplicity, and easily interpretation to provide insights into neural interactions. 7,6 Many recent studies have demonstrated that abnormal spontaneous functional connectivity (FC) as observed in patients with glaucoma, 8,7 amblyopia, 9,8 and strabismus, 10,11,9,10 between the primary visual cortex (V1) and the other cortex. Based on these studies, we further studied patients with NVG to investigate the abnormal intrinsic FC of the V1.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study</p>

Wu¹,

Wang²,

Zhu³

et al. 2020

NDT

View full text Add to dashboard Cite

The purpose was to investigate the differences in spontaneous functional connectivity (FC) of the primary visual cortex (V1) between patients with neovascular glaucoma (NVG) and healthy controls (HCs) using resting-state functional magnetic resonance imaging data. Methods: A total of 18 patients with NVG (nine males and nine females) and 18 HCs with similar age and sex background were enrolled in the study and inspected using resting-state functional magnetic resonance imaging. The differences in FC of the V1 between the two groups were compared using the independent samples t-test. We used the receiver operating characteristic (ROC) curve to compare the average FC values of NVG subjects with those of HCs. Results: FC in the left V1 and right fusiform gyrus, bilateral cuneus, and left precuneus was significantly decreased in the NVG group compared with that reported in the HC group. Meanwhile, patients with NVG presented increased FC between the right V1 and bilateral middle frontal gyrus. However, they also exhibited declining FC between the right V1 and left precuneus, and bilateral cuneus. The ROC curve analysis of each brain region indicated that the accuracy of the area under the ROC curves regarding NVG was excellent. Conclusion: NVG involves aberrant FC in the V1 in different brain areas, including the visual-related and cognitive-related regions. These findings may assist in unveiling the underlying neural mechanisms of impaired visual function in NVG.

show abstract

“…[8][9][10] Functional connectivity (FC) is a measure of the temporal correlation between multiple regions of interest (ROIs), or an ROI and other voxels throughout the brain, reflecting the integration of brain function. 11 Recent studies found abnormal spontaneous loss of function between the primary visual cortex (V1) and other cortices in strabismus, 12,13 central retinal vein occlusion, 14 glaucoma, 15 and amblyopia. 16 Visual information received by the retina is transmitted through the optic nerve and relayed by the lateral geniculate nucleus to the V1 of the occipital lobe in the form of optic radiation, that is, the striate region (V1).…”

Section: Introductionmentioning

confidence: 99%

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study</p>

Tang

Fang

et al. 2020

NDT

View full text Add to dashboard Cite

To investigate differences in the functional connectivity (FC) of the primary visual cortex between patients with corneal ulcer (CU) and healthy controls (HCs) using restingstate functional magnetic resonance imaging. Patients and Methods: A total of 30 patients with CU and 30 HCs were closely matched in terms of sex, age, and level of education. Two-sample t-test, receiver operating characteristic curve, and Pearson's correlation coefficient analyses were used to determine the differences in FC between the two groups, the mean FC value of patients with CU and HCs, and the correlation between FC signal values and clinical manifestations in different brain regions of patients. Results: The CU group showed significantly elevated FC in the left and right middle frontal gyri and lower FC with the right cuneus compared with the HC group. In addition, the FC of the right cingulate and left superior frontal gyri also increased in the CU group. The receiver operating characteristic curve revealed high diagnostic value in those brain regions. Conclusion: CU involves aberrant FC of the primary visual cortex in different brain areas, including visual-related and cognitive-related regions. This finding may unveil the underlying neural mechanisms of impaired visual function in CU.

show abstract

Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study

Cited by 29 publications

References 54 publications

Disrupted neural signals in patients with concomitant exotropia

Disrupted neural signals in patients with concomitant exotropia

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study</p>

<p>Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Corneal Ulcer: A Resting-State fMRI Study</p>

Contact Info

Product

Resources

About