Altered functional connectivity of the marginal division in Parkinson's disease with mild cognitive impairment: A pilot resting‐state fMRI study

Li, Mingge; Chen, Yuan‐yuan; Chen, Zhi‐ye; Feng, Jie; Liu, Meng‐yu; Lou, Xin; Shu, Shijie; Wang, Zhen‐fu; Ma, Lin

doi:10.1002/jmri.26548

Cited by 13 publications

(12 citation statements)

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“…Age . A total of 15 of 40 studies reported that patients with PD‐MCI were older than those without PD‐MCI (Supplementary Material 4), and our meta‐analysis confirmed that PD‐MCI patients were, on average, significantly older than patients without PD‐MCI with a significant and positive ES (= 0.36). The heterogeneity among the studies was moderate and significant.…”

Section: Resultssupporting

confidence: 69%

“…Of 21 studies, 8 revealed that PD‐MCI patients had higher H&Y stages than patients without PD‐MCI (Supplementary Material 5). Our meta‐analytic study showed that PD‐MCI patients had higher scores on the H&Y (Table ), with a significant and positive ES (= 0.33).…”

Section: Resultsmentioning

confidence: 99%

“…The data presented in more than 1 publication were used in their primary version (first publication). The remaining 41 primary studiesshowed a good methodological quality (high QUADAS score) and were included in the meta‐analysis (Supplementary Material 1b). PD‐MCI was diagnosed by using a comprehensive neuropsychological testing (ie, level II category) in 28 studies, 21 of these strictly followed the MDS clinical criteria for the diagnosis of PD‐MCI, whereas 7 used an adaptation of the MDS criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Sex . A total of 3 of 35 studies found an association between PD‐MCI and male sex (Supplementary Material 4). Our meta‐analysis revealed a significant association between male sex and the occurrence of PD‐MCI (Table ; but with very low ES [= 0.10]).…”

Section: Resultsmentioning

confidence: 99%

“…Sex. A total of 3 27,52,54 of 35 studies 4,5,11,12,14,15,[26][27][28][29][30][31][32][34][35][36][37][38][39][40][41][42][43][44][45][46][47][49][50][51][52][53][54]56,57 found an association between PD-MCI and male sex ( Supplementary Material 4). Our meta-analysis revealed a significant association between male sex and the occurrence of PD-MCI ( 4,10,12,14,33,38,39,[41][42][43]45,47,57 found an association between PD-MCI and a lower level of education ( Supplementary Material 4).…”

Section: Association With Demographic Characteristicsmentioning

confidence: 99%

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Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis

et al. 2019

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Mild cognitive impairment associated with Parkinson's disease (PD) is a risk factor for the development of dementia. Despite the importance of early identification of mild cognitive impairment in PD, its prevalence and clinical correlates are still debated. The present meta‐analysis provides a robust estimate of prevalence rate of mild cognitive impairment in PD according to the Movement Disorder Society clinical criteria and to explore the differences between PD patients with and without mild cognitive impairment in demographic, clinical, and neuropsychiatric features. A systematic literature search was performed up to April 2019 using PsycInfo (PROQUEST), PubMed, and Scopus. From 4706 titles and abstracts, 41 studies were selected (n = 7053 patients). Pooled mild cognitive impairment prevalence was 40% on a total sample of 7053 PD patients (95% confidence interval = 36–44; Q = 490.14, P < 0.0001; I2 = 91.84%) with a higher frequency for the multiple domain subtype (31%; 95% confidence interval = 23–41, Q = 93.24; P < 0.0001; I2 = 92.49%). Meta‐regression analysis revealed that stage of PD moderate prevalence estimates of mild cognitive impairment (β = 2.80; P = 0.008). Mild cognitive impairment in PD was associated with older age, lower education, longer disease duration, higher levodopa equivalent daily dose, more severe motor symptoms, and postural instability/gait difficulty motor subtype, poorer quality of life, higher levels of apathy, and depression. The present meta‐analysis indicated that mild cognitive impairment in PD is a frequent cognitive status deserving to be early detected by means of standardized cognitive assessments in clinical practice. © 2019 International Parkinson and Movement Disorder Society

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Section: Resultssupporting

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Association With Demographic Characteristicsmentioning

confidence: 99%

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Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis

et al. 2019

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Structural and Functional Thalamic Changes in Parkinson's Disease With Mild Cognitive Impairment

Liu

et al. 2020

Magnetic Resonance Imaging

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Background The thalamus is a key node of deep gray matter and previous studies have demonstrated that it is involved in the modulation of cognition. Purpose To investigate the volume changes of the thalamus and its subregions and altered thalamus functional connectivity patterns in Parkinson's disease (PD) patients with and without mild cognitive impairment (MCI). Study Type Prospective. Population Thirty‐three patients with MCI (PD‐MCI), 36 PD patients having no cognitive impairment (PD‐NCI), 21 healthy controls (HCs). Sequence 3.0T MRI scanner; 3D T1‐weighted fast spoiled gradient recalled echo (3D T1‐FSPGR); resting‐state fMRI Assessment Voxel‐based morphometry (VBM) was performed to calculate the volume of the thalamus and its subregions. The left and right total thalamus were considered seeds and seed‐based functional connectivity (FC) was analyzed. Additionally, correlations between volumes and cognitive performance and between FC values and cognitive performance were examined separately. Statistical Test Analysis of covariance (ANCOVA); two‐sample t‐tests; partial correlation analysis. Results The volumes of the total thalamus (PD‐MCI vs. PD‐NCI vs. HCs: 18.39 ± 1.67 vs. 19.63 ± 1.79 vs. 19.47 ± 1.35) and its subregions were significantly reduced in PD‐MCI as compared to PD‐NCI (total thalamus: P = 0.002) and HCs (total thalamus: P = 0.012). Compared with PD‐NCI, PD‐MCI showed increased FC between the thalamus and bilateral middle cingulate cortex and left posterior cingulate cortex, and decreased FC between thalamus and the left superior occipital gyrus, left cuneus, left precuneus, and left middle occipital gyrus. Volumes of thalamus and the subregions, as well as the FC of thalamus with the identified regions, were significantly correlated (P < 0.05, FDR‐corrected) with neuropsychological scores in PD patients. Data Conclusion We noted volume loss and altered FC of thalamus in PD‐MCI patients, and these changes were correlated with global cognitive performance. Level of Evidence 2 Technical Efficiency Stage 2 J. Magn. Reson. Imaging 2020;52:1207–1215.

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Applications of fMRI to Neurodegenerative Disease

Mahmoud,

Doksu,

Lee

et al. 2023

Functional Neuroradiology

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Altered functional connectivity of the marginal division in Parkinson's disease with mild cognitive impairment: A pilot resting‐state fMRI study

Cited by 13 publications

References 31 publications

Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis

Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta‐Analysis

Structural and Functional Thalamic Changes in Parkinson's Disease With Mild Cognitive Impairment

Applications of fMRI to Neurodegenerative Disease

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