Altered functional connectivity of dentate nucleus in parkinsonian and cerebellar variants of multiple system atrophy

Yang, HuaGuang; Wang, Na; Luo, Xiaoguang; Lv, Hong; Liu, Hu; Fan, Guoguang

doi:10.1007/s11682-019-00097-5

Cited by 16 publications

(8 citation statements)

References 58 publications

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“…However, it should be noted that injured unilateral brain function network was commonly linked to asymmetries and specific symptoms in patients with MSA. Our previous study indicated that motor and cognitive impairments in MSA patients are largely linked to right lateral brain dysfunction [ 11 , 12 , 43 ], possibly because MSA patients predominantly have a right lateral onset as participants. Therefore, it must be confirmed that the depression symptoms of MSA patients are mainly associated with changes in the right lateral brain area network with further experiments under controlling the disease onset.…”

Section: Discussionmentioning

confidence: 99%

“…From February 2014 to January 2020, 32 (16 females, 16 males) MSA-D and 30 multiple system atrophy patients without depression symptoms (MSA-ND) (14 females, 16 males) patients were registered for this study by in the Department of Neurology, Renmin Hospital, Wuhan University and the First Affiliated Hospital of China Medical University. 34 healthy controls with matched age, gender, and education also enrolled from the same city through advertisements between 2014 and 2020 (control participants have been used in our previous analyses [ 11 , 12 ]).…”

Section: Methodsmentioning

confidence: 99%

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Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms

Yang

Liu²,

Wen

et al. 2022

BMC Psychiatry

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Background It is yet unknown if the whole-brain resting-state network is altered in multiple system atrophy with symptoms of depression. This study aimed to investigate if and how depression symptoms in multiple system atrophy are associated with resting-state network dysfunction. Methods We assessed the resting-state functional network matric using Degree centrality (DC) coupling with a second ROI-wise functional connectivity (FC) algorithm in a multimodal imaging case-control study that enrolled 32 multiple system atrophy patients with depression symptoms (MSA-D), 30 multiple system atrophy patients without depression symptoms (MSA-ND), and 34 healthy controls (HC). Results Compared to HC, MSA-D showed more extensive DC hub dysfunction in the left precentral and right middle frontal cortex than MSA-ND. A direct comparison between MSA-D and MSA-ND detected increased DC in the right anterior cingulum cortex, but decreased DC in the left cerebellum lobule IV and lobule V, left middle pole temporal cortex, and right superior frontal cortex. Only right anterior cingulum cortex mean DC values showed a positive correlation with depression severity, and used ACC as seed, a second ROI-wise functional connectivity further revealed MSA-D patients showed decreased connectivity between the ACC and right thalamus and right middle temporal gyrus (MTG). Conclusions These findings revealed that dysfunction of rACC, right middle temporal lobe and right thalamus involved in depressed MSA. Our study might help to the understanding of the neuropathological mechanism of depression in MSA.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms

Yang

Liu²,

Wen

et al. 2022

BMC Psychiatry

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“…Through the cerebello-thalamocortical circuit, the cerebellum and the bilateral M1, a connected network of the cerebellum, are critical to motor control (Grimaldi et al, 2014). Pukinje cells within the cerebellum have physiological inhibitory effects on the M1 by inhibiting the dentate nucleus (Spampinato et al, 2020), which is termed cerebellar brain inhibition (CBI) (Galea et al, 2009) MSA impairs the regulation of the dentate nucleus and Purkinje cells, thereby decreasing the excitability of M1 and ultimately leading to motor control dysfunction (Yang et al, 2019a). Liu et al (2018) applied rTMS over cerebellum and bilateral M1, and the beneficial effect of rTMS might be correlated with the direct activation of M1 and the reduction of M1 inhibition by the cerebellum (Liu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Effects of Non-invasive Brain Stimulation on Multiple System Atrophy: A Systematic Review

Zhang

Wang

2021

Front. Neurosci.

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Background/Objective: Multiple system atrophy (MSA) refers to a progressive neurodegenerative disease characterized by autonomic dysfunction, parkinsonism, cerebellar ataxia, as well as cognitive deficits. Non-invasive brain stimulation (NIBS) has recently served as a therapeutic technique for MSA by personalized stimulation. The primary aim of this systematic review is to assess the effects of NIBS on two subtypes of MSA: parkinsonian-type MSA (MSA-P) and cerebellar-type MSA (MSA-C).Methods: A literature search for English articles was conducted from PubMed, Embase, Web of Science, Cochrane Library, CENTRAL, CINAHL, and PsycINFO up to August 2021. Original articles investigating the therapeutics application of NIBS in MSA were screened and analyzed by two independent reviewers. Moreover, a customized form was adopted to extract data, and the quality of articles was assessed based on the PEDro scale for clinical articles.Results: On the whole, nine articles were included, i.e., five for repetitive transcranial magnetic stimulation (rTMS), two for transcranial direct current stimulation (tDCS), one for paired associative stimulation, with 123 patients recruited. The mentioned articles comprised three randomized controlled trials, two controlled trials, two non-controlled trials, and two case reports which assessed NIBS effects on motor function, cognitive function, and brain modulatory effects. The majority of articles demonstrated significant motor symptoms improvement and increased cerebellar activation in the short term after active rTMS. Furthermore, short-term and long-term effects on improvement of motor performance were significant for tDCS. As opposed to the mentioned, no significant change of motor cortical excitability was reported after paired associative stimulation.Conclusion: NIBS can serve as a useful neurorehabilitation strategy to improve motor and cognitive function in MSA-P and MSA-C patients. However, further high-quality articles are required to examine the underlying mechanisms and standardized protocol of rTMS as well as its long-term effect. Furthermore, the effects of other NIBS subtypes on MSA still need further investigation.

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“…Limited research has employed rs‐fMRI to characterize cognition‐related network alterations in MSA patients. In these studies, Yang, Wang, Luo, Lv, Liu, and Fan ( 2019a ) found functional connectivity (FC) of the right dentate nucleus and right cerebellum was correlated with cognitive behaviors in MSA patients. In further research, Yang et al ( 2020 ) combined degree centrality (DC) and secondary FC analysis, and detected disruptions of the dorsolateral prefrontal cortex (DLPFC)‐default mode network (DMN) and DLPFC‐insula network in MSA patients with CI (MSA‐CI).…”

Section: Introductionmentioning

confidence: 99%

“…Seed‐based FC analysis measures the correlation coefficients of a pre‐defined region with other brain regions (Friston, 2011 ). Existing seed‐based FC analyses in MSA‐CI chose the seed regions based on network metrics results (Kawabata et al, 2019 ; Yang et al, 2020 ) or prior literature (Yang, Wang, Luo, Lv, Liu, & Fan, 2019a ). Corresponding network alterations based on regional neural activity changes have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Alterations of voxel‐wise spontaneous activity and corresponding brain functional networks in multiple system atrophy patients with mild cognitive impairment

Liu

et al. 2022

Human Brain Mapping

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Emerging evidence has indicated that cognitive impairment is an underrecognized feature of multiple system atrophy (MSA). Mild cognitive impairment (MCI) is related to a high risk of dementia. However, the mechanism underlying MCI in MSA remains controversial. In this study, we conducted the amplitude of low‐frequency fluctuation (ALFF) and seed‐based functional connectivity (FC) analyses to detect the characteristics of local neural activity and corresponding network alterations in MSA patients with MCI (MSA‐MCI). We enrolled 80 probable MSA patients classified as cognitively normal (MSA‐NC, n = 36) and MSA‐MCI ( n = 44) and 40 healthy controls. Compared with MSA‐NC, MSA‐MCI exhibited decreased ALFF in the right dorsal lateral prefrontal cortex (RDLPFC) and increased ALFF in the right cerebellar lobule IX and lobule IV–V. In the secondary FC analyses, decreased FC in the left inferior parietal lobe (IPL) was observed when we set the RDLPFC as the seed region. Decreased FC in the bilateral cuneus, left precuneus, and left IPL and increased FC in the right middle temporal gyrus were shown when we set the right cerebellar lobule IX as the seed region. Furthermore, FC of DLPFC‐IPL and cerebello‐cerebral circuit, as well as ALFF alterations, were significantly correlated with Montreal Cognitive Assessment scores in MSA patients. We also employed whole‐brain voxel‐based morphometry analysis, but no gray matter atrophy was detected between the patient subgroups. Our findings indicate that altered spontaneous activity in the DLPFC and the cerebellum and disrupted DLPFC‐IPL, cerebello‐cerebral networks are possible biomarkers of early cognitive decline in MSA patients.

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Altered functional connectivity of dentate nucleus in parkinsonian and cerebellar variants of multiple system atrophy

Cited by 16 publications

References 58 publications

Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms

Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms

Effects of Non-invasive Brain Stimulation on Multiple System Atrophy: A Systematic Review

Alterations of voxel‐wise spontaneous activity and corresponding brain functional networks in multiple system atrophy patients with mild cognitive impairment

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