Altered functional connectivity of cerebellar dentate nucleus in peak-dose dyskinesia in Parkinson’s disease

Zhang, Heng; Wang, Lina; Gan, Caiting; Cao, Xingyue; Ji, Min; Sun, Huimin; Yuan, Yongsheng; Zhang, Kezhong

doi:10.3389/fnagi.2022.943179

Cited by 2 publications

(1 citation statement)

References 55 publications

(72 reference statements)

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“…Cortico‐STN coherence with a frequency‐specific topography has been detected in subjects with PD on and off of L‐dopa medication 38 . Recent findings suggest that strengthened connectivity between the cerebellar dentate nucleus and putamen reduces dyskinetic symptoms, 39 and functional connectivity has been used as an indicator of DBS eligibility in patients with early PD 40 . Moreover, structural and functional connectivity predicted motor improvement independently in subjects with PD 41 .…”

Section: Discussionmentioning

confidence: 99%

Eltoprazine modulated gamma oscillations on ameliorating L‐dopa‐induced dyskinesia in rats

Wang

et al. 2023

CNS Neurosci Ther

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AimParkinson's disease (PD) is a pervasive neurodegenerative disease, and levodopa (L‐dopa) is its preferred treatment. The pathophysiological mechanism of levodopa‐induced dyskinesia (LID), the most common complication of long‐term L‐dopa administration, remains obscure. Accumulated evidence suggests that the dopaminergic as well as non‐dopaminergic systems contribute to LID development. As a 5‐hydroxytryptamine 1A/1B receptor agonist, eltoprazine ameliorates dyskinesia, although little is known about its electrophysiological mechanism. The aim of this study was to investigate the cumulative effects of chronic L‐dopa administration and the potential mechanism of eltoprazine's amelioration of dyskinesia at the electrophysiological level in rats.MethodsNeural electrophysiological analysis techniques were conducted on the acquired local field potential (LFP) data from primary motor cortex (M1) and dorsolateral striatum (DLS) during different pathological states to obtain the information of power spectrum density, theta‐gamma phase–amplitude coupling (PAC), and functional connectivity. Behavior tests and AIMs scoring were performed to verify PD model establishment and evaluate LID severity.ResultsWe detected exaggerated gamma activities in the dyskinetic state, with different features and impacts in distinct regions. Gamma oscillations in M1 were narrowband manner, whereas that in DLS had a broadband appearance. Striatal exaggerated theta‐gamma PAC in the LID state contributed to broadband gamma oscillation, and aperiodic‐corrected cortical beta power correlated robustly with aperiodic‐corrected gamma power in M1. M1–DLS coherence and phase‐locking values (PLVs) in the gamma band were enhanced following L‐dopa administration. Eltoprazine intervention reduced gamma oscillations, theta–gamma PAC in the DLS, and coherence and PLVs in the gamma band to alleviate dyskinesia.ConclusionExcessive cortical gamma oscillation is a compelling clinical indicator of dyskinesia. The detection of enhanced PAC and functional connectivity of gamma‐band oscillation can be used to guide and optimize deep brain stimulation parameters. Eltoprazine has potential clinical application for dyskinesia.

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Section: Discussionmentioning

confidence: 99%

Eltoprazine modulated gamma oscillations on ameliorating L‐dopa‐induced dyskinesia in rats

Wang

et al. 2023

CNS Neurosci Ther

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Clinical and neurophysiological features of the augmentation phenomenon in restless legs syndrome

Gorbachev,

Obukhova,

Fedeneva

et al. 2024

RJTAO

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Anxiety and depressive disorders are common in restless legs syndrome (RLS); in some cases, the disease is accompanied by cognitive impairment and a deterioration in quality of life. The most important treatment method for RLS is the use of dopaminergic medications. In some cases, the use of these drugs leads to a complication - the phenomenon of augmentation, which manifests itself in an increase in RLS symptoms as the dose of medication increases.Objective: to determine the clinical and neurophysiological characteristics of RLS patients with the augmentation phenomenon.Material and methods. 40 patients with RLS were examined: 20 with augmentation (main group, MG; 5 men and 15 women) and 20 without augmentation (comparison group, CG; 7 men and 13 women). The median age of the patients in the MG was 63.5 [56; 71] years, and 62.0 [43.5; 71.5] years in the CG. Clinical assessment was performed using the RLS Severity Rating Scale (RS), Montreal Cognitive Assessment Scale (MoCA), Beck Anxiety Inventory, Beck Depression Inventory, Quality of Life Scale (SF-36), Insomnia Severity Index (ISI), Trail Making Test (Part A), Trail Making Test (part B), phonemic and semantic speech activity tests. All patients underwent suggested immobilization test (SIT) to assess the urge to move on a 10-point numerical rating scale (NRS) and periodic limb movements (PLM) while awake, as well as a polysomnographic examination.Results. Augmentation significantly more frequently resulted in an expansion of the area of distribution of the urge to move and other unpleasant sensations over the entire surface of the legs (p=0.01), painful discomfort in the legs (p=0.001), early onset of symptoms (04:00—18:00; p=0.04), shortening of the latency period for the onset of symptoms (p=0.001), twitching in the legs while awake (p=0.04), taking higher doses of dopaminergic medications (p=0.004). In augmentation, the MoCA score is lower (p=0.01), such patients use fewer words in the semantic speech activity test (p=0.049), have a higher score on the RS (p=0.001) and ISI (p=0.02), a greater number of PLMs while awake according to SIT (p=0.01) compared to CG. No significant differences were found between groups in terms of age, gender, ferritin level, total score on the Beck Anxiety and Depression Inventory, SF-36 Quality of Life Scale, Trail Making Test (Part A), Trail Making Test (part B), phonemic speech activity test, polysomnography indicators (including motor activity during sleep).Conclusion. From a clinical and neurophysiological point of view, the phenomenon of augmentation is not simply a manifestation of a more severe course of RLS but has features that reflect the pathogenesis of this disorder. During augmentation, patients tend to describe the sensations as painful and their involuntary motor activity increases. This reflects changes in the activity of the diencephalospinal tract due to excessive dopaminergic stimulation.

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Altered functional connectivity of cerebellar dentate nucleus in peak-dose dyskinesia in Parkinson’s disease

Cited by 2 publications

References 55 publications

Eltoprazine modulated gamma oscillations on ameliorating L‐dopa‐induced dyskinesia in rats

Eltoprazine modulated gamma oscillations on ameliorating L‐dopa‐induced dyskinesia in rats

Clinical and neurophysiological features of the augmentation phenomenon in restless legs syndrome

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