Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation

Qi, Jing; Li, Bo-Zhi; Zhang, Ying; Pan, Bei; Gao, Yu‐Hong; Zhan, Hao; Liu, Yong; Shao, Yuanyuan; Zhang, Xi

doi:10.1016/j.bbr.2021.113321

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…For example, chronic pain conditions are frequently accompanied by sleep disorders, which are pathogenic in worsening their prognosis and treatment response 52,53 . Sleep deprivation has been shown to lead to reduced connectivity of the NBM to the prefrontal cortex 54 . Furthermore, neuronal loss in the NBM has been reported in Fig.…”

Section: Discussionmentioning

confidence: 99%

Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

Oswald

Han

et al. 2022

Nat Commun

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The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer’s and Parkinson’s dementias. Despite the crucial role of neocortical domains in pain perception, however, the NBM has not been studied in models of chronic pain. Here, using in vivo tetrode recordings in behaving mice, we report that beta and gamma oscillatory activity is evoked in the NBM by noxious stimuli and is facilitated at peak inflammatory pain-like behavior. Optogenetic and chemogenetic cell-specific, reversible manipulations of NBM cholinergic-GABAergic neurons reveal their role in endogenous control of nociceptive hypersensitivity, which are manifest via projections to the prelimbic cortex, resulting in layer 5-mediated antinociception. Our data unravel the importance of the NBM in top-down control of neocortical processing of pain-like behavior.

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Section: Discussionmentioning

confidence: 99%

Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

Oswald

Han

et al. 2022

Nat Commun

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“…As the primary source of cholinergic projections to the cortex, the BNM supports wakefulness and attention ( Qi et al, 2021 ). Though accounting only for approximately 5% of the neuronal populations in the basal forebrain, the cholinergic neurons play a central role in modulating sleep-wake homeostasis ( Gritti et al, 2006 ; Nikonova et al, 2017 ), increasing and decreasing in activities during attentive wakefulness/REM sleep and non-REM sleep, respectively ( Xu et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

“…Human studies associated BNM neuronal loss with premortem sleep deficits ( Kasanuki et al, 2018 ) and lower BNM connectivity with left visual cortices in patients with sleep disorder and mild cognitive impairment ( Byun et al, 2022 ). In rodent studies, 36 hours of total sleep deprivation, compared with rested wakefulness, led to higher BNM-thalamus/cingulate cortex and lower BNM-right superior parietal lobule connectivity, with BNM-cingulate cortex connectivity negatively correlated with attention performance following total sleep deprivation ( Qi et al, 2021 ). Contributing to altered physiological responses as well as cognitive and emotional problems ( Irwin, 2019 ), sleep deficit is noted in individuals with many different neuropsychiatric conditions, including anxiety and other mood disorders ( Nutt et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Sleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men

Li,

Zhong,

et al. 2023

International Journal of Neuropsychopharmacology

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Background The basal nucleus of Meynert (BNM), a primary source of cholinergic projections to the cortex, plays key roles in regulating sleep-wake cycle and attention. Sleep deficit is associated with impairment in cognitive and emotional functions. However, whether or how cholinergic circuit, sleep, cognitive/emotional dysfunction are inter-related remains unclear. Methods We curated the Human Connectome Project data and explored BNM resting state functional connectivities (rsFC) in relation to sleep deficit, based on the Pittsburgh Sleep Quality Index (PSQI), cognitive performance, and subjective reports of emotional states in 687 young adults (342 women). Imaging data were processed with published routines and evaluated at a corrected threshold. We assessed the correlation between BNM rsFC, PSQI, and clinical measurements with Pearson regressions and their inter-relationships with mediation analyses. Results In whole-brain regressions with age and alcohol use severity as covariates, men showed lower BNM rsFC with the posterior cingulate cortex (PCC) in correlation with PSQI score. No clusters were identified in women at the same threshold. Both BNM-PCC rsFC and PSQI score were significantly correlated with anxiety, perceived stress, and neuroticism scores in men. Moreover, mediation analyses showed that PSQI score mediated the relationship between BNM-PCC rsFC and these measures of negative emotions bidirectionally in men. Conclusions Sleep deficit is associated with negative emotions and lower BNM rsFC with the PCC. Negative emotional states and BNM-PCC rsFC are bidirectionally related through poor sleep quality. These findings are specific to men, suggesting potential sex differences in the neural circuits regulating sleep and emotional states.

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Total sleep deprivation impairs visual selective attention and triggers a compensatory effect: evidence from event-related potentials

Song

Peng

et al. 2022

Cogn Neurodyn

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Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation

Cited by 4 publications

References 43 publications

Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

Sleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men

Total sleep deprivation impairs visual selective attention and triggers a compensatory effect: evidence from event-related potentials

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