Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes

Chen, Luo; Yang, Fang; Deng, Jiayan; Zhang, Yaodan; Hou, Changyue; Huang, Yue; Cao, Weifang; Wang, Jianjun; Xiao, Ruhui; Zeng, Nanlin; Wang, Xiaoming; Yao, Dezhong

doi:10.1097/md.0000000000003831

Cited by 21 publications

(35 citation statements)

References 48 publications

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“…The orbitofrontal cortex (OFC) in particular has repeatedly shown disease‐related variations, with decreased regional homogeneity (ReHo) values, less dynamic variability, and greater isolation from other networks . This latter pattern has also been observed in a study reporting greater anticorrelation between the DMN and executive networks . Both increases and decreases of connectivity within frontal regions are reported, with the variability likely being related to choice of analytical method and specific ROIs.…”

Section: Functional Network In Cectsmentioning

confidence: 85%

“…A mixed pattern of increases and decreases in connectivity strength between the DMN and other brain regions has also been reported. Specifically, increased connectivity between the left and right superior frontal cortices and decreased connectivity between the DMN and language‐related cortical regions have been observed. Another study dividing children with CECTS into groups with and without attention‐deficit/hyperactivity disorder (ADHD) found increased connectivity between DMN and regions of visual association cortex in both groups compared to healthy controls …”

Section: Functional Network In Cectsmentioning

confidence: 99%

“…A positive correlation between the segregation of DMN components, that is, the extent to which the anatomic network components were able to function independently, and intelligence quotient (IQ), verbal comprehension, and perceptual reasoning has been reported . In other studies, however, tests of correlation between connectivity measures and IQ reveal no significant results even when performance in one or more domains is decreased in the children with CECTS . None of the reviewed papers included targeted assessments of social cognition.…”

Section: Functional Network In Cectsmentioning

confidence: 99%

“…Although inadequately studied to date, there is some suggestion of a relationship between connectivity patterns in the OFC and performance IQ and between the dorsal attention network and ADHD comorbid with CECTS . Three studies of children with CECTS have found no correlation between connectivity measures and general IQ scores . None of the studies of children with CECTS, however, has examined the relationship between executive networks and performance on psychometric assessments of executive function directly.…”

Section: Functional Network In Cectsmentioning

confidence: 99%

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The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

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Our objective was to summarize and evaluate the rapidly expanding body of literature studying functional connectivity in childhood epilepsy. In the self‐limited childhood epilepsies, awareness of cognitive comorbidities has been steadily increasing, and recent advances in our understanding of the network effects of these disorders promise insights into the underlying neurobiology. We reviewed publications addressing functional connectivity in children with epilepsy with an emphasis on studies of children with self‐limited childhood epilepsies. The majority of studies have been published in the past 10 years and predominantly examine childhood epilepsy with centrotemporal spikes and childhood absence epilepsy. Cognitive network alterations are commonly observed across the childhood epilepsies. Some of these effects appear to be nonspecific to epilepsy syndrome or even to category of neurological disorder. Other patterns, such as changes in the connectivity of cortical language areas in childhood epilepsy with centrotemporal spikes, provide clues to the underlying cognitive deficits seen in affected children. The literature to date is dominated by general observations of connectivity patterns without a priori hypotheses. These data‐driven studies build an important foundation for hypothesis generation and are already providing useful insights into the neuropathology of the childhood epilepsies. Future work should emphasize hypothesis‐driven approaches and rigorous clinical correlations to better understand how the knowledge of network alterations can be applied to guidance and treatment for the children in our clinics.

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Section: Functional Network In Cectsmentioning

confidence: 85%

Section: Functional Network In Cectsmentioning

confidence: 99%

Section: Functional Network In Cectsmentioning

confidence: 99%

Section: Functional Network In Cectsmentioning

confidence: 99%

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The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

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“…Structural (T1‐weighted, T2‐weighted, fluid‐attenuated inversion recovery [FLAIR]) magnetic resonance (MR) imaging in BECTS usually fails to reveal pathological cerebral abnormalities on visual analyses . Several groups have recently investigated functional connectivity in children with RE . These studies have yielded divergent findings, in terms of directionality (increases or decreases) and localization of alterations in connectivity (Table ).…”

Section: Resting Functional Mri Connectivity Studies In Bectsmentioning

confidence: 99%

Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes

et al. 2017

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SummaryObjectiveBenign epilepsy with centrotemporal spikes (BECTS, also known as Rolandic epilepsy) is a common epilepsy syndrome that is associated with literacy and language impairments. The neural mechanisms of the syndrome are not known. The primary objective of this study was to test the hypothesis that functional connectivity within the language network is decreased in children with BECTS. We also tested the hypothesis that siblings of children with BECTS have similar abnormalities.MethodsEcho planar magnetic resonance (MR) imaging data were acquired from 25 children with BECTS, 12 siblings, and 20 healthy controls, at rest. After preprocessing with particular attention to intrascan motion, the mean signal was extracted from each of 90 regions of interest. Sparse, undirected graphs were constructed from adjacency matrices consisting of Spearman's rank correlation coefficients. Global and nodal graph metrics and subnetwork and pairwise connectivity were compared between groups.ResultsThere were no significant differences in graph metrics between groups. Children with BECTS had decreased functional connectivity relative to controls within a four‐node subnetwork, which consisted of the left inferior frontal gyrus, the left superior frontal gyrus, the left supramarginal gyrus, and the right inferior parietal lobe (p = 0.04). A similar but nonsignificant decrease was also observed for the siblings. The BECTS groups had significant increases in connectivity within a five‐node, five‐edge frontal subnetwork.SignificanceThe results provide further evidence of decreased functional connectivity between key mediators of speech processing, language, and reading in children with BECTS. We hypothesize that these decreases reflect delayed lateralization of the language network and contribute to specific cognitive impairments.

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Dynamic visual cortical connectivity analysis based on functional magnetic resonance imaging

et al. 2020

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Background Studies of brain functional connectivity (FC) and effective connectivity (EC) using the functional magnetic resonance imaging (fMRI) have advanced our understanding of functional organization on visual cortex of human brain. The current studies mainly focus on static or dynamic connectivity, while the relationships between them have not been well characterized especially for static EC (sEC) and dynamic EC (dEC), as well as the consistency characteristics of changing trend of dFCs and dECs, which is of great importance to reveal the neural information processing mechanism in visual cortex region. Method In this study, we explore these relationships among several subareas of human visual cortex (V1–V5) by calculating the connection intensity and information flow among them over time by sliding window method, which are defined by Pearson correlation coefficient and Granger causality analysis, respectively, in each window. Results The results demonstrate that there are extensive connections existing in human visual network, which are time‐varying both in resting and task‐related states. sFC intensity is negatively correlated with the variance of dFC, while sEC intensity is positively correlated with the variance of dEC. Furthermore, we also find that dFC within visual cortex at rest shows more consistency, while dEC shows less compared with task state in changing trend. Conclusion Therefore, this study provides novel findings about dynamics of connectivity in human visual cortex from the perspective of functional and effective connectivity.

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Altered functional and effective connectivity in anticorrelated intrinsic networks in children with benign childhood epilepsy with centrotemporal spikes

Abstract: Supplemental Digital Content is available in the text

Cited by 21 publications

References 48 publications

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

Decreased functional connectivity within a language subnetwork in benign epilepsy with centrotemporal spikes

Dynamic visual cortical connectivity analysis based on functional magnetic resonance imaging

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