Altered frontostriatal relationship in unmedicated schizophrenic patients

Abnormalities in the Distributed Network of Sustained Attention Predict Neuroleptic Treatment Response in Schizophrenia

“…In summary, our findings that treatment-resistant schizophrenics demonstrate frontal hypometabolism in the presence of striatal hyperactivity is very similar to the data reported by two other groups working with schizophrenic patients who had never received neuroleptics before (Biver et al 1995;Rubin et al 1991). Rubin et al (1991) interpreted their results, obtained while patients performed the Wisconsin Card Sort, as suggestive of impaired striatal suppression on the left side.…”

Hypofrontality in schizophrenia: a meta‐analysis of functional imaging studies

“…Forty‐seven studies reported values for relative frontal blood flow/metabolism (10–12, 14, 32, 33, 35, 40–43, 47, 50–55, 57, 58–86). The pooled effect size for these was −0.24 (CI −0.34 to −0.15).…”

“…Twenty‐nine studies reported absolute frontal values (9, 11, 12, 13, 17, 31, 33, 35–37, 39–41, 45, 49–51, 53, 54, 56, 62, 63, 74, 80, 82, 83, 87–90) and these gave a pooled effect size of −0.33 (CI −0.45 to −0.22). These studies were also heterogeneous ( Q = 63.77, P = 0.0001) but homogeneity was achieved by excluding four studies (11, 17, 40, 74).…”

Striatal function in relation to negative symptoms in schizophrenia

“…Similarly, the results of fluorodeoxyglucose positron emission tomography (FDG-PET) studies have been conflicting, with some studies demonstrating elevated (Wolkin et al 1985 ;Biver et al 1995) and others finding reduced (Buchsbaum et al 1982 ;Siegel et al 1993) striatal metabolic rates in schizophrenia.…”