Altered fronto-occipital connectivity during visual selective attention in regular cannabis users

Rangel-Pacheco, Abril; Lew, Brandon J.; Schantell, Mikki; Frenzel, Michaela R.; Eastman, Jacob A.; Wiesman, Alex I.; Wilson, Tony W.

doi:10.1007/s00213-020-05717-3

Cited by 18 publications

(29 citation statements)

References 74 publications

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“…Also, the small and type of population samples can be related to differences between studies. Some studies have reported a detriment in the executive control system in adolescent cannabis users (Abdullaev et al, 2010, Cengel et al, 2018, but not others (Rangel-Pacheco et al, 2020;Vilar-López et al, 2013), as ours. It could be because our participants had a later cannabis use…”

Section: Discussioncontrasting

confidence: 43%

“…It has also been reported that cannabis abstinence for at least 23 days in adolescent cannabis users still presented poorer attention efficiency relative to non-using control adolescents (Medina, Hanson, Schweinsburg, et al, 2007); this effect was negatively related to lifetime cannabis use. Contrasting studies have failed to document cannabisinduced attention impairment (Chang et al, 2006;Indlekofer et al, 2009;Rangel-Pacheco et al, 2020;Scott et al, 2018;Vilar-López et al, 2013). The inconsistency of these results may be due to the type of task used (Colizzi & Bhattacharyya, 2018), the differences among the samples evaluated, such as the frequency of cannabis use, the age at onset, total consumption time, whether the subject has developed cannabis dependence, or the time required for an abstinence period from cannabis.…”

Section: Introductionmentioning

confidence: 99%

“…A concern with all these studies is the small samples used and the assessment of the attention networks in adolescent cannabis users. However, in adult cannabis users, performing tasks that evaluate orienting (e.g., Chang et al, 2006) and executive control (Rangel-Pacheco et al, 2020) systems, independently, have shown no behavioral changes but altered brain activation (Chang et al, 2006) and prefrontal-occipital connectivity (Rangel-Pacheco et al, 2020) relative to control subjects.…”

Section: Introductionmentioning

confidence: 99%

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The Alerting and Orienting Systems of Attention Are Modified by Cannabis Dependence

Ortega-Mora

Caballero-Sánchez

Román-López

et al. 2021

J Int Neuropsychol Soc

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Attention allows us to select relevant information from the background. Although several studies have described that cannabis use induces deleterious effects on attention, it remains unclear if cannabis dependence affects the attention network systems differently.Objectives:To evaluate whether customary consumption of cannabis or cannabis dependence impacts the alerting, orienting, and executive control systems in young adults; to find out whether it is related to tobacco or alcohol dependence and if cannabis use characteristics are associated with the attention network systems.Method:One-hundred and fifty-four healthy adults and 102 cannabis users performed the Attention Network Test (ANT) to evaluate the alerting, orienting, and executive control systems.Results:Cannabis use enhanced the alerting system but decreased the orienting system. Moreover, those effects seem to be associated with cannabis dependence. Out of all the cannabis-using variables, only the age of onset of cannabis use significantly predicted the efficiency of the orienting and executive control systems.Conclusion:Cannabis dependence favors tonic alertness but reduces selective attention ability; earlier use of cannabis worsens the efficiency of selective attention and resolution of conflicts.

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Section: Discussioncontrasting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Alerting and Orienting Systems of Attention Are Modified by Cannabis Dependence

Ortega-Mora

Caballero-Sánchez

Román-López

et al. 2021

J Int Neuropsychol Soc

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“…Unfortunately, hair sample analysis was not available for eight participants from the control group. However, it is important to note that biological measures of drug use (illicit substances or psychotropic medication) is rarely used in nonusing controls in the research field on cannabis (or other illicit drugs) and self-reported measures dominate for CU (Smith et al, 2017;Khajehpour et al, 2019;Rangel-Pacheco et al, 2020) or the urine/hair sample analyses detect cannabis use only (no other illicit drugs nor psychotropic medication) (Yücel et al, 2016;Prashad et al, 2018). That is why we would consider it as an additional value of our study and exclusion of this participants form analyses would make CG too small to obtain reliable results.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Not Just a Pot: Visual Episodic Memory in Cannabis Users and Polydrug Cannabis Users: ROC and ERP Preliminary Investigation

Binkowska

Jakubowska

Gaca

et al. 2021

Front. Hum. Neurosci.

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Background While research has consistently identified an association between long-term cannabis use and memory impairments, few studies have examined this relationship in a polydrug context (i.e., when combining cannabis with other substances).Aims: In this preliminary study, we used event-related potentials to examine the recognition process in a visual episodic memory task in cannabis users (CU) and cannabis polydrug users (PU). We hypothesized that CU and PU will have both–behavioral and psychophysiological–indicators of memory processes affected, compared to matched non-using controls with the PU expressing more severe changes.Methods 29 non-using controls (CG), 24 CU and 27 PU were enrolled into the study. All participants completed a visual learning recognition task while brain electrical activity was recorded. Event-related potentials were calculated for familiar (old) and new images from a signal recorded during a subsequent recognition test. We used receiver operating characteristic curves for behavioral data analysis.Results The groups did not differ in memory performance based on receiver operating characteristic method in accuracy and discriminability indicators nor mean reaction times for old/new images. The frontal old/new effect expected from prior research was observed for all participants, while a parietal old/new effect was not observed. While, the significant differences in the late parietal component (LPC) amplitude was observed between CG and PU but not between CG and CU nor CU and PU. Linear regression analysis was used to examine the mean amplitude of the LPC component as a predictor of memory performance accuracy indicator. LPC amplitude predicts recognition accuracy only in the CG.Conclusion The results showed alterations in recognition memory processing in CU and PU groups compared to CG, which were not manifested on the behavioral level, and were the most prominent in cannabis polydrug users. We interpret it as a manifestation of the cumulative effect of multiple drug usage in the PU group.

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“…This special issue on the use of imaging in drug evaluation brings together studies that provide examples of where imaging has been used to address the challenges outlined above. It includes a number of good examples of the use of imaging to advance understanding of pathophysiology that can be used to guide the development of new treatments, specifically for smoking and cannabis use disorders (Rangel-Pacheco et al 2021;Blest-Hopley et al 2021;Tamburin et al 2021), although the principles they demonstrate apply equally to other conditions. Neurochemical imaging has proved particularly informative for understanding pathophysiology and drug action (McCutcheon et al 2020).…”

mentioning

confidence: 99%

Challenges in CNS drug development and the role of imaging

Howes

Mehta

2021

Psychopharmacology

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Altered fronto-occipital connectivity during visual selective attention in regular cannabis users

Cited by 18 publications

References 74 publications

The Alerting and Orienting Systems of Attention Are Modified by Cannabis Dependence

The Alerting and Orienting Systems of Attention Are Modified by Cannabis Dependence

Not Just a Pot: Visual Episodic Memory in Cannabis Users and Polydrug Cannabis Users: ROC and ERP Preliminary Investigation

Challenges in CNS drug development and the role of imaging

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