Altered frontal inter-hemispheric resting state functional connectivity is associated with bulimic symptoms among restrained eaters

Chen, Shuaiyu; Dong, Debo; Jackson, Todd; Su, Yao; Chen, Hong

doi:10.1016/j.neuropsychologia.2015.06.036

Cited by 19 publications

(14 citation statements)

References 104 publications

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“…Specifically, dietary restraint was associated with reductions in connectivity between the dlPFC and regions involved in reward processing (e.g. vmPFC) and self-directed thinking and memory (PCC; Chen et al , 2016 ), which may contribute to episodes of disinhibited eating frequently experienced by individuals high in dietary restraint. This hypothesis is supported by the observation that reductions in dlPFC connectivity were associated with symptoms of BN among those characterized as restrained eaters ( Chen et al, 2016 ).…”

Section: Relationship Between Disordered Eating Behaviors and Functiomentioning

confidence: 99%

A review of the relationship between eating behavior, obesity and functional brain network organization

Donofry

Stillman

Erickson

2019

Social Cognitive and Affective Neuroscience

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Abstract Obesity is a major public health issue affecting nearly 40% of American adults and is associated with increased mortality and elevated risk for a number of physical and psychological illnesses. Obesity is associated with impairments in executive functions such as decision making and inhibitory control, as well as in reward valuation, which is thought to contribute to difficulty sustaining healthy lifestyle behaviors, including adhering to a healthy diet. Growing evidence indicates that these impairments are accompanied by disruptions in functional brain networks, particularly those that support self-regulation, reward valuation, self-directed thinking and homeostatic control. Weight-related differences in task-evoked and resting-state connectivity have most frequently been noted in the executive control network (ECN), salience network (SN) and default mode network (DMN), with obesity generally being associated with weakened connectivity in the ECN and enhanced connectivity in the SN and DMN. Similar disruptions have been observed in the much smaller literature examining the relationship between diet and disordered eating behaviors on functional network organization. The purpose of this narrative review was to summarize what is currently known about how obesity and eating behavior relate to functional brain networks, describe common patterns and provide recommendations for future research based on the identified gaps in knowledge.

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Section: Relationship Between Disordered Eating Behaviors and Functiomentioning

confidence: 99%

A review of the relationship between eating behavior, obesity and functional brain network organization

Donofry

Stillman

Erickson

2019

Social Cognitive and Affective Neuroscience

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“…The DLPFC and the medial prefrontal cortex including the OFC have been reported to be critically involved in impulsive behaviors (Cho et al, 2013) as well as in the cognitive and emotion regulation (Kober et al, 2010). In line with our findings, Chen et al (2016) observed reduced homotopic connectivity in the DLPFC of 'restrained eaters'. This reduction was linked to the failure in inhibiting hedonic eating as well as to the lack of top-down control of appetite, which both involve the DLPFC (Jasinska et al, 2011;Brooks et al, 2013).…”

Section: Discussionmentioning

confidence: 92%

“…In line with our findings, Chen et al . () observed reduced homotopic connectivity in the DLPFC of ‘restrained eaters’. This reduction was linked to the failure in inhibiting hedonic eating as well as to the lack of top‐down control of appetite, which both involve the DLPFC (Jasinska et al ., ; Brooks et al ., ).…”

Section: Discussionmentioning

confidence: 96%

Interhemispheric functional connectivity in anorexia and bulimia nervosa

Canna

Prinster

Monteleone

et al. 2017

Eur J of Neuroscience

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The functional interplay between hemispheres is fundamental for behavioral, cognitive, and emotional control. Anorexia nervosa (AN) and bulimia nervosa (BN) have been largely studied with brain magnetic resonance imaging (MRI) in relation to the functional mechanisms of high-level processing, but not in terms of possible inter-hemispheric functional connectivity anomalies. Using resting-state functional MRI (fMRI), voxel-mirrored homotopic connectivity (VMHC) and regional inter-hemispheric spectral coherence (IHSC) were studied in 15 AN and 13 BN patients and 16 healthy controls (HC). Using T1-weighted and diffusion tensor imaging MRI scans, regional VMHC values were correlated with the left-right asymmetry of corresponding homotopic gray matter volumes and with the white matter callosal fractional anisotropy (FA). Compared to HC, AN patients exhibited reduced VMHC in cerebellum, insula, and precuneus, while BN patients showed reduced VMHC in dorso-lateral prefrontal and orbito-frontal cortices. The regional IHSC analysis highlighted that the inter-hemispheric functional connectivity was higher in the 'Slow-5' band in all regions except the insula. No group differences in left-right structural asymmetries and in VMHC vs. callosal FA correlations were significant in the comparisons between cohorts. These anomalies, not explained by structural changes, indicate that AN and BN, at least in their acute phase, are associated with a loss of inter-hemispheric connectivity in regions implicated in self-referential, cognitive control and reward processing. These findings may thus gather novel functional markers to explore aberrant features of these eating disorders.

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“…Our study was consistent with this notion. Thus, we interpret a persistent reduction in impulsiveness as indexed by the intertemporal choice task is a consequence of eating difficulties experienced by patients as a result of their orthodontics devices through the common neural circuit of behavioral inhibition and impulsivity (Chen S. et al, 2016 ). Our findings build on this evidence by suggesting that the impact of eating inhibition on behavior not only affect food-related behavior, but also can also be extended to general decision making tasks.…”

Section: Discussionmentioning

confidence: 98%

Impulsiveness in Reactive Dieters: Evidence From Delay Discounting in Orthodontic Patients

Zhang

Mai

Chen

et al. 2018

Front. Hum. Neurosci.

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Introduction: Researchers have made efforts to distinguish the behavioral differences and underlying mechanisms that explain the various possible outcomes of dieting (success, failure and relapse). Although extensive research has demonstrated that eating behavior and individual impulsiveness are closely related to subjective appetite and decision making, very few studies have investigated how subjective and appetite impulsiveness is affected by reactive dieting.Methods: In the present study, we utilized the power of food scale (PFS) and the intertemporal choice task and to examine subjective appetite and impulsivity of decision making in orthodontic patients. As a result of their orthodontic devices and the subsequent pain and discomfort caused by eating, these patients become reactive dieters. In order to explore the dynamic influence of orthodontic treatment on appetite and impulsiveness, we collected data for both patients and control participants across three testing sections. We also computed a regression model for further exploration in explaining how potential factors contributed to different choices.Results: We found that the orthodontic group scored significantly lower in PFS than the control group, which indicated a suppression in appetite. Besides, reward and waiting time were significant factors in computational perspective. Moreover, although patients showed a bias in choosing smaller, immediate reward options, they exhibited a decrease in the delay discounting rate as treatment progressed. These findings confirm that subjective appetite and impulsiveness were inhibited due to reactive dieting.

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Altered frontal inter-hemispheric resting state functional connectivity is associated with bulimic symptoms among restrained eaters

Cited by 19 publications

References 104 publications

A review of the relationship between eating behavior, obesity and functional brain network organization

A review of the relationship between eating behavior, obesity and functional brain network organization

Interhemispheric functional connectivity in anorexia and bulimia nervosa

Impulsiveness in Reactive Dieters: Evidence From Delay Discounting in Orthodontic Patients

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