Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia

Tsunoda, Tomoya; Kanba, Shigenobu; Ueno, Takefumi; Hirano, Yoji; Hirano, Shogo; Maekawa, Toshihiko; Onitsuka, Toshiaki

doi:10.1016/j.clinph.2012.01.024

Cited by 41 publications

(49 citation statements)

References 40 publications

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“…More generally, the results may reflect less efficient allocation of attentional ressources (Basar-Eroglu & Demiralp, 2001). Thus, our results complement behavioural studies indicating that top-down driven organising principles of perception in schizophrenia is weak (John & Hemsley, 1992;Silverstein & Keane, 2011;Tsunoda, et al, 2012).…”

Section: Altered Theta Response During Multistable Perception In Schisupporting

confidence: 83%

“…Thus, behavioural studies indicate that the influence of top-down processes on the perception of ambiguous figures is diminished in schizophrenia. This is in accordance with the broader scope of the patient's deficiencies in using contextual information during object perception (Silverstein & Keane, 2011) and implies that in schizophrenia top-down driven organising principles of perception are weak (John & Hemsley, 1992;Silverstein & Keane, 2011;Tsunoda et al, 2012).…”

Section: Top-down Processes In Schizophrenia Investigated By Visual Isupporting

confidence: 70%

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Theta response in schizophrenia is indifferent to perceptual illusion

Mathes

Schmiedt-Fehr

Kedilaya

et al. 2016

Clinical Neurophysiology

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Section: Altered Theta Response During Multistable Perception In Schisupporting

confidence: 83%

Section: Top-down Processes In Schizophrenia Investigated By Visual Isupporting

confidence: 70%

Theta response in schizophrenia is indifferent to perceptual illusion

Mathes

Schmiedt-Fehr

Kedilaya

et al. 2016

Clinical Neurophysiology

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“…One consistent cognitive dysfunction in people diagnosed with schizophrenia involves non-emotional face processing (for reviews see Darke et al, 2013; Onitsuka et al, 2013; Watson, 2013; Bortolon et al, 2015; McCleery et al, 2015) both at behavioral (Chen, 2011; Maher et al, 2015, 2016) and physiological levels (Herrmann et al, 2004; Onitsuka et al, 2006; Tsunoda et al, 2012; Maher et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Sluggishness of Early-Stage Face Processing (N170) Is Correlated with Negative and General Psychiatric Symptoms in Schizophrenia

Zheng

Ning

et al. 2016

Front. Hum. Neurosci.

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Patients with schizophrenia consistently exhibit abnormalities in the N170 event-related potential (ERP) component evoked by images of faces. However, the relationship between these face-specific N170 abnormalities in patients with schizophrenia and the clinical characteristics of this disorder has not been elucidated. Here, ERP recordings were conducted for patients with schizophrenia and healthy controls. The amplitude and latency of the N170 component were recorded while participants passively viewed face and non-face (table) images to explore the correlation between face-specific processing and clinical characteristics in schizophrenia. The results provided evidence for a face-specific N170 latency delay in patients with schizophrenia. The N170 latency in patients with schizophrenia was significantly longer than that in healthy controls when images of faces were presented in both upright and inverted orientations. Importantly, the face-related N170 latencies of the left temporo-occipital electrodes (P7 and PO7) were positively correlated with both negative and general psychiatric symptoms in these patients. The N170 amplitudes were weaker in patients than in controls for inverted images of both faces and non-faces (tables), with a left-hemisphere dominance. The face inversion effect (FIE), meaning the difference in N170 amplitude between upright and inverted faces, was absent in patients with schizophrenia, suggesting an abnormality of holistic face processing. Together, these results revealed a marked symptom-relevant neural delay associated with face-specific processing in patients with schizophrenia, providing additional evidence to support the demyelination hypothesis of schizophrenia.

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“…To take again the example of electrophysiological brain response to human faces, atypical neural response is observed in both ASD (21-23) and SZS (24-26) but is not universal in either population (27-35). Rather than corresponding to diagnostic boundaries, variability in neural response to faces reflects dimensional deficits across disorders such as social competence (33, 34), distress (36), empathy (37), emotional sensitivity (38), global functioning (39), and social engagement (25, 29, 40). …”

Section: Challenges To Biomarker Development In Asdmentioning

confidence: 99%

Considerations in biomarker development for neurodevelopmental disorders

McPartland¹

2016

Current Opinion in Neurology

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Purpose of review Despite significant progress in recognizing the biological bases of autism spectrum disorder, diagnosis and treatment rely primarily on subjective evaluation of behavior. This review highlights the challenges unique to neurodevelopmental disorders that have limited biomarker development. Recent findings The field of neurodevelopmental disorders requires objective quantification of biological processes to enable designation of subgroups likely to benefit from specific treatments, index diagnostic status/risk, demonstrate engagement of targeted systems, and provide more rapid assessment of change than traditional clinical observation and caregiver report measures. Summary Useful biomarkers for neurodevelopmental disorders must be reliable across development, evident at the individual level, and specific to a unit of analysis, be it diagnostic status or functional process. The ultimate value of biomarkers for neurodevelopmental disorders will relate to their ease of use, cost, scalability, sensitivity, and methodological objectivity.

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Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia

Cited by 41 publications

References 40 publications

Theta response in schizophrenia is indifferent to perceptual illusion

Theta response in schizophrenia is indifferent to perceptual illusion

Sluggishness of Early-Stage Face Processing (N170) Is Correlated with Negative and General Psychiatric Symptoms in Schizophrenia

Considerations in biomarker development for neurodevelopmental disorders

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