Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice

Lubka-Pathak, Maria; Shah, Aftab Ali; Gallozzi, Micaela; Müller, Marcus; Zimmermann, Ulrike; Löwenheim, Hubert; Pfister, Markus; Knipper, Marlies; Blin, Nikolaus; Schimmang, Thomas

doi:10.1007/s00018-010-0586-1

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…Clinical findings have shown that TFF3 is the strongest predictor of neurodegeneration across the spectrum of cerebral amyloidosis, with significant reductions in TFF3 levels observed in patients with vascular parkinsonism dementia, Parkinson's disease dementia, and Alzheimer's disease [37,38]. Similarly, TFF3 −/− mice has been shown to induce hearing impairment, accelerated presbycusis, and worsened stroke outcomes [20,39,40]. These observations imply that TFF3 plays non-negligible roles in both physiological and pathological processes.…”

Section: Pathological Effects Of Tff3 In Disease Tff3 In T2dmmentioning

confidence: 99%

Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective

Yang

Lin

et al. 2022

Cell Death Dis

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Trefoil factor 3 (TFF3) is the last small-molecule peptide found in the trefoil factor family, which is mainly secreted by intestinal goblet cells and exerts mucosal repair effect in the gastrointestinal tract. Emerging evidence indicated that the TFF3 expression profile and biological effects changed significantly in pathological states such as cancer, colitis, gastric ulcer, diabetes mellitus, non-alcoholic fatty liver disease, and nervous system disease. More importantly, mucosal protection would no longer be the only effect of TFF3, it gradually exhibits carcinogenic activity and potential regulatory effect of nervous and endocrine systems, but the inner mechanisms remain unclear. Understanding the molecular function of TFF3 in specific diseases might provide a new insight for the clinical development of novel therapeutic strategies. This review provides an up-to-date overview of the pathological effects of TFF3 in different disease and discusses the binding proteins, signaling pathways, and clinical application.

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Section: Pathological Effects Of Tff3 In Disease Tff3 In T2dmmentioning

confidence: 99%

Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective

Yang

Lin

et al. 2022

Cell Death Dis

View full text Add to dashboard Cite

show abstract

“…Mice lacking the trefoil factor 3 (Tff3) peptide were shown to suffer from age‐related hearing loss, and microarray analysis showed deregulated expression of the transcriptional regulator securin (Pttg1) and the protease inhibitor serpina3n (Lubka‐Pathak et al. ).…”

Section: Gene Expression Profiling In Mutant Micementioning

confidence: 99%

Gene expression profiling of the inner ear

Schimmang

Maconochie

2015

Journal of Anatomy

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The identification of transcriptional differences has served as an important starting point in understanding the molecular mechanisms behind biological processes and systems. The developmental biology of the inner ear, the biology of hearing and of course the pathology of deafness are all processes that warrant a molecular description if we are to improve human health. To this end, technological innovation has meant that larger scale analysis of gene transcription has been possible for a number of years now, extending our molecular analysis of genes to beyond those that are currently in vogue for a given system. In this review, some of the contributions gene profiling has made to understanding developmental, pathological and physiological processes in the inner ear are highlighted.

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High throughput gene expression analysis of the inner ear

Hertzano

Elkon

2012

Hearing Research

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Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice

Cited by 4 publications

References 52 publications

Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective

Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective

Gene expression profiling of the inner ear

High throughput gene expression analysis of the inner ear

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