Altered expression of innate immunity genes in different intestinal sites of children with ulcerative colitis

Stronati, Laura; Negroni, Anna; Pierdomenico, Maria; D’Ottavio, Chiara; Tirindelli, Donatella; Nardo, Giovanni Di; Oliva, Salvatore; Viola, Franca; Cucchiara, Salvatore

doi:10.1016/j.dld.2010.04.003

Cited by 29 publications

(21 citation statements)

References 53 publications

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“…Subsequent over-activation of the intestinal immune system results in elevated secretion of enteric alpha defensins (as well as TNF alpha and IL1 beta) suggesting that Helicobacter is able to avoid the innate and adaptive immune response in human intestine by as yet unknown mechanisms [58]. …”

Section: Introductionmentioning

confidence: 99%

Enteric alpha defensins in norm and pathology

Лисицын

Bukurova

Nikitina

et al. 2012

Ann Clin Microbiol Antimicrob

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Microbes living in the mammalian gut exist in constant contact with immunity system that prevents infection and maintains homeostasis. Enteric alpha defensins play an important role in regulation of bacterial colonization of the gut, as well as in activation of pro- and anti-inflammatory responses of the adaptive immune system cells in lamina propria. This review summarizes currently available data on functions of mammalian enteric alpha defensins in the immune defense and changes in their secretion in intestinal inflammatory diseases and cancer.

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Section: Introductionmentioning

confidence: 99%

Enteric alpha defensins in norm and pathology

Лисицын

Bukurova

Nikitina

et al. 2012

Ann Clin Microbiol Antimicrob

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“…25,26 As another unexpected but interesting finding we observed significantly increased levels of both alpha-defensins in the TI of children with UC, which confirms recent data published in an Italian pediatric patient cohort. 27 An obvious explanation might be that local upregulation of alpha-defensins in some way minimizes terminal ileal inflammation in UC; however, further studies are required to investigate the relevance and potential mechanisms of this observation.…”

Section: Discussionmentioning

confidence: 94%

Intestinal alpha-defensin expression in pediatric inflammatory bowel disease1

Zilbauer¹,

Jenke²,

Wenzel³

et al. 2011

Inflammatory Bowel Diseases

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In this study no difference in alpha-defensin expression was found in the TI of CD children and controls. However, significant reduction of Tcf-4 in L1+L3 phenotype suggests that a possibly impaired PC differentiation may lead to altered HD5 and HD6 expression at some stage of disease. Additionally, substantially increased expression of alpha-defensins in the inflamed colonic mucosa of children with IBD raises the question for their potential involvement in modulating inflammation in these patients.

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“…The bacterium causes hyperactivation of the intestinal immune system, and, surprisingly, this hyperactivation is accompanied by higher secretion of DEFA5. It seems that H. pylori is capable of inhibiting activation of the defense reaction cascade (see the previous section) [53]. The molecular mechanisms of the inhibition are unclear in this case.…”

Section: Role Of Enteric α Defensinsmentioning

confidence: 97%