Altered expression of fatty acid–metabolizing enzymes in aromatase-deficient mice

A loss of aggressive behaviour and its reinstatement by oestrogen in mice lacking the aromatase gene (Cyp19)

“…Female ArKO mice are totally infertile and show features similar to those seen in ovariectomised mice, such as diminution in size of the uteri and decreased density of bones. In ArKO males, we observed a reduced reproductive ability and the development of hepatic steatosis, which is attributable, at least in part, to down-regulation of enzymatic activities involved in fatty-acid -oxidation reactions in hepatocytes (Nemoto et al 2000).…”

Another role highlighted for estrogens in the male: Sexual behavior

“…Analysis of the phenotypes resulting from these mutations has revealed various degrees and types of infertility in both male and female, depending on the mutation involved. Lipid and carbohydrate phenotypes involving increased adiposity with insulin resistance, hyperlipidemia and hyperleptinemia as well as disturbances in behavior patterns, both social and sexual, have also been described (6)(7)(8). These studies reveal that estrogens have more extensive roles in physiology than was previously thought, and moreover these are frequently of a non-sexually dimorphic nature.…”

“…3) knockout, in addition to the aromatase knockout (ArKO; refs. [4][5][6] mice. Analysis of the phenotypes resulting from these mutations has revealed various degrees and types of infertility in both male and female, depending on the mutation involved.…”

Características Estereológicas del Hígado de Rata (Rattus norvergicus) sometidas a Menopausia Inducida por Ovariectomía

“…Respecto a la función hepática, Di Martino et al (2004), Codes et al (2007a) demostraron que las mujeres premenopáusicas presentaban una menor cantidad de fibrosis hepática que las mujeres postmenopáusicas y cuando se administraba terapia hormonal de reemplazo, el hígado mostraba parámetros similares al grupo premenopáusico. Nemoto et al, (2000) demostraron que la esteatosis hepática se hizo evidente de manera espontánea en ratas y en ratones con deficiencia de la enzima aromatasa, por tanto, carecen de la capacidad intrínseca de producir estrógeno. Yasuda et al (1999) demostraron que al aplicar terapia de estradiol, existe una reducción de la fibrosis y de la esteatosis hepática.…”