Altered expression of circadian rhythm genes among individuals with a history of depression

Gouin, Jean‐Philippe; Connors, James J.; Kiecolt‐Glaser, Janice K.; Glaser, Ronald; Malarkey, William B.; Atkinson, Cathie; Beversdorf, David Q.; Quan, Ning

doi:10.1016/j.jad.2010.04.002

Cited by 61 publications

(29 citation statements)

References 39 publications

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“…Similarly, one study suggests that clock gene expression in tissues related to pregnancy is altered in mice during pregnancy, although this has not been tested yet in humans . No data have been published thus far regarding the expression of clock genes during perinatal depression, while history of depression has been found to be associated with the increased expression of gene CLOCK that would be responsible for an anticipation of the sleep‐waking rhythms and of late insomnia typical in MDD . Furthermore, MDD, including perinatal depression, has been associated with different biological abnormalities including increased global inflammation .…”

Section: Different Degree Of Methylation (And Consequent Expression) mentioning

confidence: 99%

The role of clock genes in perinatal depression: the light in the darkness

Buoli

Grassi

Iodice

et al. 2019

Acta Psychiatr Scand

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Section: Different Degree Of Methylation (And Consequent Expression) mentioning

confidence: 99%

The role of clock genes in perinatal depression: the light in the darkness

Buoli

Grassi

Iodice

et al. 2019

Acta Psychiatr Scand

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“…Alterations in the expression of circadian genes — specifically Clock, Bmal1 and Per1 — have been observed in patients with a history of depression 68 . Animal models with mutations or disruptions in the circadian machinery show changes in mood and behavior.…”

Section: Mental Disorders and The Clockmentioning

confidence: 99%

The circadian clock: a framework linking metabolism, epigenetics and neuronal function

2012

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The circadian clock machinery is responsible for biological timekeeping on a systemic level. The central clock system controls peripheral clocks through a number of output cues that synchronize the system as a whole. There is growing evidence that changing cellular metabolic states have important effects on circadian rhythms and can thereby influence neuronal function and disease. Epigenetic control has also been implicated in the modulation of biological timekeeping, and cellular metabolism and epigenetic state seem to be closely linked. We discuss the idea that cellular metabolic state and epigenetic mechanisms may work through the circadian clock to potentially regulate neuronal function and to influence disease states.

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“…172 Subjects with depression exhibit increased leukocyte clock mRNA expression. 173 Several Clock [174][175][176]177,178 single-nucleotide polymorphisms have been linked to MDD 174 and seasonal affective disorder, 177,178 as well as to bipolar depression 174,177,178 symptoms 175 and recurrence. 176 MT 2 receptor activation inhibits NO-induced increases in cyclic GMP 179 -of interest because plasma cGMP levels have been noted to be increased in patients developing depression after receiving 6 weeks of interferon treatment.…”

Section: Additional Heuristic Melatonergic Antidepressant and Anxiolymentioning

confidence: 99%

Agomelatine in Depressive Disorders: Its Novel Mechanisms of Action

Srinivasan¹,

Zakaria²,

Othman³

et al. 2012

JNP

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Disruptions in sleep and sleep-wake cycle regulation have been identified as one of the main causes for the pathophysiology of depressive disorders. The search has been on for the identification of an ideal antidepressant that could improve both sleep disturbances and depressive symptomatology. Melatonin, the major hormone of the pineal gland, has been shown to improve sleep and is involved in the regulation of the sleep-wake cycle. Identification of high concentrations of MT1 and MT2 melatonergic receptors in the suprachiasmatic nucleus of the anterior hypothalamus, the structure concerned with regulation of circadian rhythms and sleep-wake cycles, has led to the development of melatonergic agonists with greater potency and longer durations of action. Agomelatine is one such melatonergic agonist that acts specifically on MT1/MT2 melatonergic receptors and at the same time exhibits 5-HT2C antagonism, a property that is utilized by current antidepressants that are in clinical use. Agomelatine has been shown to be effective in a number of animal models of depression. Clinical studies undertaken on patients with major depression, bipolar disorders, seasonal affective disorder, and generalized anxiety disorder have all shown that agomelatine is also very effective in ameliorating depressive symptoms and manifesting early onset of action with a good tolerability and safety profile. It improved sleep efficiency and also resynchronized the disrupted circadian rhythms. Hence, the melatonergic modulation by agomelatine is suggested as one of the mechanisms for its antidepressant effect. Agomelatine's action on dendritic neurogenesis in animal models of depression is also identified as yet another action.

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Altered expression of circadian rhythm genes among individuals with a history of depression

Abstract: Background-Depression has been associated with several circadian rhythm perturbations, suggesting a disruption of the circadian clock system in affective disorders. The interaction of several circadian clock genes generates these daily circadian rhythms.

Cited by 61 publications

References 39 publications

The role of clock genes in perinatal depression: the light in the darkness

The role of clock genes in perinatal depression: the light in the darkness

The circadian clock: a framework linking metabolism, epigenetics and neuronal function

Agomelatine in Depressive Disorders: Its Novel Mechanisms of Action

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