Altered expression of c-kit-positive cells in the ureterovesical junction after surgically created vesicoureteral reflux

Oberritter, Zsolt; Rolle, Udo; Juhász, Zsolt; Cserni, Tamás; Puri, Prem

doi:10.1007/s00383-009-2487-7

Cited by 7 publications

(3 citation statements)

References 26 publications

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“…Indeed there are an increasing number of reports describing that the number of Kit + cells decreases in pathological of conditions in the upper urinary tract; conditions including ureteropelvic obstruction [28] or refluxing and obstructive megaureter in human [75–77] and ureteral obstruction induced in rats [78] or ureterovescial reflux in pigs [79, 80]. In contrast, the number of Kit + cells is increased in bladder outlet obstruction in guinea pigs [17] and human overactive bladder [25].…”

Section: Future Issues Of Icc‐lc Research In the Urogenital Organsmentioning

confidence: 99%

Functions of ICC‐like cells in the urinary tract and male genital organs

Hashitani

Lang

2010

J Cellular Molecular Medi

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Interstitial cells of Cajal (ICC)-like cells (ICC-LCs) have been identified in many regions of the urinary tract and male genital organs by immunohistochemical studies and electron microscopy. ICC-LCs are characterized by their spontaneous electrical and Ca2+ signalling and the cellular mechanisms of their generation have been extensively investigated. Spontaneous activity in ICC-LCs rises from the release of internally stored Ca2+ and the opening of Ca2+-activated Cl− channels to generate spontaneous transient depolarizations (STDs) in a manner not fundamentally dependent on Ca2+ influx through L-type voltage-dependent Ca2+ channels. Since urogenital ICC-LCs have been identified by their immunoreactivity to Kit (CD117) antibodies, the often-used specific marker for ICC in the gastrointestinal tract, their functions have been thought likely to be similar. Thus ICC-LCs in the urogenital tract might be expected to act as either electrical pacemaker cells to drive the smooth muscle wall or as intermediaries in neuromuscular transmission. However, present knowledge of the functions of ICC-LCs suggests that their functions are not so predetermined, that their functions may be very region specific, particularly under pathological conditions. In this review, we summarize recent advances in our understanding of the location and function of ICC-LCs in various organs of the urogenital system. We also discuss several unsolved issues regarding the identification, properties and functions of ICC-LCs in various urogenital regions in health and disease.

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Section: Future Issues Of Icc‐lc Research In the Urogenital Organsmentioning

confidence: 99%

Functions of ICC‐like cells in the urinary tract and male genital organs

Hashitani

Lang

2010

J Cellular Molecular Medi

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“…Activation of mast cells in the ureter has been implicated in pathological conditions such as renal colic and vesicoureteral reflux (24). In conditions where the urothelium is damaged and urine can penetrate the bladder wall, activation of mast cells may contribute to inflammation by releasing several inflammatory mediators such as histamine and tryptase.…”

Section: Discussionmentioning

confidence: 99%

Urothelial Cell Platelet-activating Factor Production Mediated by Calcium-independent Phospholipase A2γ

Rastogi

Rickard

Klumpp

et al. 2011

Urology

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Purpose-To determine the effect of phospholipase A 2 (PLA 2 ) inhibitors on urothelial cell platelet-activating factor (PAF) production in response to tryptase stimulation. Results-The majority of PLA 2 activity measured in TEU-2 cells was determined to be membrane-associated, calcium-independent (iPLA 2 ) and selective for plasmenylcholine substrate. Stimulation of TEU-2 cells with tryptase results in increased production of platelet-activating factor (PAF) and increased polymorphonuclear leukocyte (PMN) adherence that were inhibited completely by pretreatment with the iPLA 2 γ-selective inhibitor (R)-bromoenol lactone ((R)-BEL). Pretreatment with the cytosolic PLA 2 inhibitor methyl arachidonyl fluorophosphonate (MAFP) results in potentiation of tryptase-stimulated PAF production and PMN adherence to TEU-2 cells that is a result of PAF-acetylhydrolase (PAF-AH) inhibition. Materials and Methods-Urothelial

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“…In transplantation studies, stem cells from various tissues such as from the heart or bone marrow have become an important alternative source to using donor organs or whole tissue for engraftment (1)(2)(3)(4)(5). The development of new reagents and methods are needed for the identification of stem cell markers and for monitoring their purification, transplantation and differentiation in foreign environments such as with the xeno-transplantation of stem cells between different animal species, because most of the tools today are cross-reactive monoclonal antibodies prepared against human antigens and not species specific (6).…”

Section: Introductionmentioning

confidence: 99%

Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody

Ohshima¹,

Mori²,

Shigenari³

et al. 2014

BST

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Altered expression of c-kit-positive cells in the ureterovesical junction after surgically created vesicoureteral reflux

Abstract: Surgically created VUR leads to altered expression of c-kit-positive cells. The altered distribution of c-kit-positive ICC-like cells might further contribute to the impairment of coordinated pyeloureteral peristalsis.

Cited by 7 publications

References 26 publications

Functions of ICC‐like cells in the urinary tract and male genital organs

Functions of ICC‐like cells in the urinary tract and male genital organs

Urothelial Cell Platelet-activating Factor Production Mediated by Calcium-independent Phospholipase A2γ

Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody

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