“…25,40,50,56 Current data and other reports therefore support the idea that deflazacort-induced hypertrophy and increased ␣-cardiac MHC occurred largely independent of the renin-angiotensin system. 21,27,35,57 Protection from contraction-induced damage may derive from combined increases in laminin, tau- rine, and bFGF that could stabilize membranes, mediate calcium homeostasis, and protect against peroxidation injury, respectively. 1,14,15,23,45 The correlative pattern of cellular and metabolic changes here suggests that H-NMRS was able to track evolving cardiomyopathy and treatment effects.…”