“…The common theme emerging from the different reports strongly suggests that abnormalities in Reelin-mediated signaling not only increases the vulnerability to develop psychosis, it clearly promotes the development of moderate to severe cognitive dysfunctions. In addition to these psychiatric diseases, abnormalities in Reelin have been associated with some forms of human epilepsy, particularly mesial temporal lobe epilepsy (Haas et al, 2002) which is characterized by profound hippocampal sclerosis involving loss of pyramidal neurons, granule cell dispersion and reactive gliosis, as well as a significant reorganization of GABA A receptor subunit expression (Loup et al, 2006;Loup et al, 2009). …”